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Ec2la - ≥98%(HPLC), high purity , CAS No.2244579-87-9, Allosteric modulator of CB 2 receptor

Moligand™

≥98%(HPLC)

CAS#: 2244579-87-9
Formula: C₂₁H₂₄BrFN₂O₂
Molecular Weight: 435.33
PubChem CID: 137553165

Item Number

E288545

Grouped product items
SKU	Size	Availability	Price
E288545-5mg	5mg	In stock	$147.90
E288545-10mg	10mg	In stock	$246.90
E288545-25mg	25mg	In stock	$543.90
E288545-50mg	50mg	In stock	$939.90
E288545-100mg	100mg	In stock	$1,533.90

Positive allosteric modulator of CB2receptors; activein vivo

View related series

CB2 receptor Allosteric modulator

Basic Description

Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	CB2receptor positive allosteric modulator. EnhancesCP 55940 and 2-Arachidonylglycerol-stimulated binding of [35S]GTPγS to CB2receptors, but has no effect in the absence of agonist. Exhibits antinociceptive effects in an animal model of neuropathic pain.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of CB 2 receptor

Associated Targets(Human)

CNR2 Tchem Cannabinoid receptor 2 (2 Activities)

Discover Target: CNR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

Discover Target: CNR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CNR2 Tchem Cannabinoid CB2 receptor (16942 Activities)

Discover Target: CNR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide
INCHI	InChI=1S/C21H24BrFN2O2/c1-14-18(22)13-25(12-15-8-10-17(23)11-9-15)21(27)19(14)24-20(26)16-6-4-2-3-5-7-16/h8-11,13,16H,2-7,12H2,1H3,(H,24,26)
InChi Key	NSGDYZCDUPSTQT-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=O)N(C=C1Br)CC2=CC=C(C=C2)F)NC(=O)C3CCCCCC3
Isomeric SMILES	CC1=C(C(=O)N(C=C1Br)CC2=CC=C(C=C2)F)NC(=O)C3CCCCCC3
PubChem CID	137553165
Molecular Weight	435.33

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
F2307390	Certificate of Analysis	May 08, 2023	E288545
F2307393	Certificate of Analysis	May 08, 2023	E288545
F2307394	Certificate of Analysis	May 08, 2023	E288545
F2307398	Certificate of Analysis	May 08, 2023	E288545
F2307401	Certificate of Analysis	May 08, 2023	E288545
F2307403	Certificate of Analysis	May 08, 2023	E288545
F2308065	Certificate of Analysis	May 08, 2023	E288545
F2308070	Certificate of Analysis	May 08, 2023	E288545
F2308071	Certificate of Analysis	May 08, 2023	E288545
F2309405	Certificate of Analysis	May 08, 2023	E288545

References

1. Gado F, Di Cesare Mannelli L, Lucarini E, Bertini S, Cappelli E, Digiacomo M, Stevenson LA, Macchia M, Tuccinardi T, Ghelardini C et al.. (2019) Identification of the First Synthetic Allosteric Modulator of the CB₂ Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief.. J Med Chem, 62 (1): (276-287). [PMID:29990428] [10.1021/op500134e]

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Ec2la - ≥98%(HPLC), high purity , CAS No.2244579-87-9, Allosteric modulator of CB 2 receptor

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action