efgartigimod alfa, Antibody of Fc fragment of IgG receptor and transporter

Features and benefits

Item Number

Ab175520

Grouped product items
SKU	Size	Availability	Price	Qty
Ab175520-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,668.90
Ab175520-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,668.90

View related series

Product Name

efgartigimod alfa

Synonyms

ARGX-113;efgartigimod alfa-fcab;Vyvgart

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Antibody of Fc fragment of IgG receptor and transporter

Associated Targets(Human)

FCGRT Tclin IgG receptor FcRn large subunit p51 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FCGRT Tclin IgG receptor FcRn large subunit p51 (445 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

References

1. Liu L, Garcia AM, Santoro H, Zhang Y, McDonnell K, Dumont J, Bitonti A. (2007) Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade.. J Immunol, 178 (8): (5390-8). [PMID:17404325]
2. Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC. (2006) Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.. Int Immunol, 18 (12): (1759-69). [PMID:17077181]
3. Vaccaro C, Zhou J, Ober RJ, Ward ES. (2005) Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.. Nat Biotechnol, 23 (10): (1283-8). [PMID:16186811]
4. Roopenian DC, Akilesh S. (2007) FcRn: the neonatal Fc receptor comes of age.. Nat Rev Immunol, 7 (9): (715-25). [PMID:17703228]

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Basic Description