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efgartigimod alfa, Antibody of Fc fragment of IgG receptor and transporter

Features and benefits

Item Number

Ab175520

Grouped product items
SKU	Size	Availability	Price	Qty
Ab175520-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,668.90
Ab175520-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,668.90

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Basic Description

Product Name	efgartigimod alfa
Synonyms	ARGX-113;efgartigimod alfa-fcab;Vyvgart
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antibody of Fc fragment of IgG receptor and transporter

CAS	Ab175520

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IMGT/mAb-DB	731

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1. Liu L, Garcia AM, Santoro H, Zhang Y, McDonnell K, Dumont J, Bitonti A. (2007) Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade.. J Immunol, 178 (8): (5390-8). [PMID:17404325]
2. Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC. (2006) Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.. Int Immunol, 18 (12): (1759-69). [PMID:17077181]
3. Vaccaro C, Zhou J, Ober RJ, Ward ES. (2005) Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.. Nat Biotechnol, 23 (10): (1283-8). [PMID:16186811]
4. Roopenian DC, Akilesh S. (2007) FcRn: the neonatal Fc receptor comes of age.. Nat Rev Immunol, 7 (9): (715-25). [PMID:17703228]

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