Basic Description

Synonyms	6-cyano-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-1-(pentan-3-yl)-1H-indole-4-carboxamide \| NCGC00351776-03 \| HY-15573 \| AS-55788 \| CCG-268533 \| EI1; Ezh2 inhibitor \| 6-Cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-
Specifications & Purity	Moligand™, ≥96%
Biochemical and Physiological Mechanisms	EI1 demonstrated potent, concentration-dependent inhibition of the enzymatic activity against both Ezh2 wild-type and Y641F mutant enzymes with IC50 of 15 ± 2 nM and 13 ± 3 nM, respectively. Although SAM is the common cofactor for all HMTs, EI1 showed rem
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit
Note	Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.

Associated Targets(Human)

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 (8 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide
INCHI	InChI=1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)
InChi Key	PFHDWRIVDDIFRP-UHFFFAOYSA-N
Canonical SMILES	CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C
Isomeric SMILES	CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C
PubChem CID	72199293
Molecular Weight	390.48

PubChem CID	72199293
CAS Registry No.	1418308-27-6

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5 results found

Lot Number	Certificate Type	Date	Item
J2213710	Certificate of Analysis	Jul 16, 2024	E125706
J2213711	Certificate of Analysis	Jul 16, 2024	E125706
J2213712	Certificate of Analysis	Jul 16, 2024	E125706
J2213730	Certificate of Analysis	Jul 16, 2024	E125706
J2213767	Certificate of Analysis	Jul 16, 2024	E125706

Solubility	insoluble in H2O; insoluble in EtOH; ≥19.5 mg/mL in DMSO
Sensitivity	light sensitive

1. Qi W, Chan H, Teng L, Li L, Chuai S, Zhang R, Zeng J, Li M, Fan H, Lin Y et al.. (2012) Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.. Proc Natl Acad Sci USA, 109 (52): (21360-5). [PMID:23236167]

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SKU	Size	Availability	Price
E125706-5mg	5mg	In stock	$102.90
E125706-10mg	10mg	In stock	$173.90
E125706-25mg	25mg	In stock	$391.90
E125706-50mg	50mg	In stock	$521.90
E125706-100mg	100mg	In stock	$756.90