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EI1 - 96%, high purity , CAS No.1418308-27-6, Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit

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EI1 - 96%, high purity , CAS No.1418308-27-6, Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit

Moligand™
≥96%

CAS#: 1418308-27-6
Formula: C₂₃H₂₆N₄O₂
Molecular Weight: 390.48
PubChem CID: 72199293

Item Number

E125706

Grouped product items
SKU	Size	Availability	Price
E125706-5mg	5mg	In stock	$102.90
E125706-10mg	10mg	In stock	$173.90
E125706-25mg	25mg	In stock	$391.90
E125706-50mg	50mg	In stock	$521.90
E125706-100mg	100mg	In stock	$756.90

Potent and selective EZH2 inhibitor

View related series

enhancer of zeste 2 polycomb repressive complex 2 subunit Inhibitor

Basic Description

Synonyms	1418308-27-6\|EI1\|KB-145943\|6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide\|6-Cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide\|6-Cyano-N-[(1,2-dihydro-4,6-dimethyl
Specifications & Purity	96%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of enhancer of zeste 2 polycomb repressive complex 2 subunit
Product Description	EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.

Associated Targets

EZH2 Tclin Histone-lysine N-methyltransferase EZH2 8 Activities

Discover Target: EZH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide
INCHI	InChI=1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)
InChi Key	PFHDWRIVDDIFRP-UHFFFAOYSA-N
Canonical SMILES	CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C
Isomeric SMILES	CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C
PubChem CID	72199293
Molecular Weight	390.48

Database links

PubChem CID	72199293
CAS Registry No.	1418308-27-6

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
J2213710	Certificate of Analysis	Jul 16, 2024	E125706
J2213711	Certificate of Analysis	Jul 16, 2024	E125706
J2213712	Certificate of Analysis	Jul 16, 2024	E125706
J2213730	Certificate of Analysis	Jul 16, 2024	E125706
J2213767	Certificate of Analysis	Jul 16, 2024	E125706

Chemical and Physical Properties

Solubility	insoluble in H2O; insoluble in EtOH; ≥19.5 mg/mL in DMSO
Sensitivity	light sensitive

References

1. Qi W, Chan H, Teng L, Li L, Chuai S, Zhang R, Zeng J, Li M, Fan H, Lin Y et al.. (2012) Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.. Proc Natl Acad Sci USA, 109 (52): (21360-5). [PMID:23236167]

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