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EIPA - ≥95%, high purity , CAS No.1154-25-2, Allosteric modulator of α 2A-adrenoceptor;Channel blocker of ASIC1;Channel blocker of TRPP2
Inhibits TRPP3-mediated currents; also inhibits the Na+/H+exchanger (NHE)
Basic Description
| Synonyms | EIPA|1154-25-2|Ethylisopropylamiloride|5-(N-Ethyl-N-isopropyl)amiloride|5-(Ethylisopropyl)amiloride|Ethyl isopropyl amiloride|5-(N-ethyl-N-isopropyl)-Amiloride|3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide|3-Ami |
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| Specifications & Purity | Moligand™, ≥95% |
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| Biochemical and Physiological Mechanisms | TRPP3 channel inhibitor (IC50= 10.5μM). Inhibits the Na+/H+exchanger (NHE). Derivative ofamiloride. |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | ALLOSTERIC MODULATOR, CHANNEL BLOCKER |
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| Mechanism of action | Allosteric modulator of α 2A-adrenoceptor;Channel blocker of ASIC1;Channel blocker of TRPP2 |
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Names and Identifiers
| IUPAC Name | 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide |
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| INCHI | InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20) |
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| InChi Key | QDERNBXNXJCIQK-UHFFFAOYSA-N |
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| Canonical SMILES | CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C |
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| Isomeric SMILES | CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C |
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| WGK Germany | 3 |
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| PubChem CID | 1795 |
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| Molecular Weight | 299.76 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 29.98, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 14.99, Max Conc. mM: 50 |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
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| WGK Germany | 3 |
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References
| 1. Li, M., Li, S., Huang, Y., Chen, H., Zhang, S., Zhang, Z., Wu, W., Zeng, X., Zhou, B., and Li, B.. (2021) Secreted expression of mRNA-encoded truncated ACE2 variants for SARS-CoV-2 via lipid-like nanoassemblies.. Adv. Mater. , 34 (33): (2101707). [PMID:] |
| 2. Huang, Y., Yang, M., Wang, N., Li, S., Liu, Z., Li, Z., Ji, Z., and Li, B.. (2022) Intracellular delivery of messenger RNA to macrophages with surfactant-derived lipid nanoparticles. Mater. Today Adv., 16 (NA): (100295 ). [PMID:] |
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