EIPA - ≥95%, high purity , CAS No.1154-25-2, Allosteric modulator of α 2A-adrenoceptor;Channel blocker of ASIC1;Channel blocker of TRPP2

7 Citations
Item Number
N132356
Grouped product items
SKUSizeAvailabilityPrice Qty
N132356-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$48.90
N132356-25mg
25mg
In stock
$220.90
N132356-100mg
100mg
In stock
$444.90

Inhibits TRPP3-mediated currents; also inhibits the Na+/H+exchanger (NHE)

Basic Description

Synonyms5-(Ethylisopropyl)amiloride | Ethylisopropyl amiloride | EU-0100045 | HY-101840 | SMR000326875 | Tox21_500045 | 3-Amino-N-(aminoiminomethyl)-6-chloro-5-(ethyl(1-methylethyl)amino)pyrazinecarboxamide | DTXSID80151084 | N-Amidino-3-amino-5-ethylisopropylami
Specifications & PurityMoligand™, ≥95%
Biochemical and Physiological MechanismsTRPP3 channel inhibitor (IC50= 10.5μM). Inhibits the Na+/H+exchanger (NHE). Derivative ofamiloride.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR, CHANNEL BLOCKER
Mechanism of actionAllosteric modulator of α 2A-adrenoceptor;Channel blocker of ASIC1;Channel blocker of TRPP2

Associated Targets(Human)

SLC9A1 Tchem Sodium/hydrogen exchanger 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLC9A5 Tchem Sodium/hydrogen exchanger 5 (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PKD2L1 Tchem Polycystic kidney disease 2-like 1 protein (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2A Tclin Alpha-2A adrenergic receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ASIC1 Tchem Acid-sensing ion channel 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR5A Tchem Serotonin 5a (5-HT5a) receptor (1433 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMPD1 Tchem Sphingomyelin phosphodiesterase (13561 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC9A3 Tclin Sodium/hydrogen exchanger 3 (483 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC9A5 Tchem Sodium/hydrogen exchanger 5 (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THPO Tbio Thrombopoietin (834 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATXN2 Tbio Ataxin-2 (54410 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Opioid receptors; mu & delta (1530 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PAX8 Tchem Paired box protein Pax-8 (1910 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

SLC9A1 Sodium/hydrogen exchanger 1 (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC9A2 Sodium/hydrogen exchanger 2 (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NHE1 Sodium/hydrogen exchanger (7 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
INCHI InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChi Key QDERNBXNXJCIQK-UHFFFAOYSA-N
Canonical SMILES CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C
Isomeric SMILES CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C
WGK Germany 3
PubChem CID 1795
Molecular Weight 299.76

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
A2426043Certificate of AnalysisDec 14, 2022 N132356
B2309418Certificate of AnalysisDec 14, 2022 N132356
B2309422Certificate of AnalysisDec 14, 2022 N132356
B2309424Certificate of AnalysisDec 14, 2022 N132356
E2408044Certificate of AnalysisDec 14, 2022 N132356
F2307397Certificate of AnalysisDec 14, 2022 N132356
J2310204Certificate of AnalysisDec 14, 2022 N132356

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 29.98, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 14.99, Max Conc. mM: 50

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3

Related Documents

Citations of This Product

1. Xucan Yang, Lulu Cheng, Yile Zhao, Haoran Ma, Haitao Song, Xuanmin Yang, Kang-Nan Wang, Yanrong Zhang.  (2024)  Aggregation-induced emission-active iridium (III)-based mitochondria-targeting nanoparticle for two-photon imaging-guided photodynamic therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  659  (320).  [PMID:38176241]
2. Dan Yuan, Qi Li, Qibo Zhang, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao.  (2024)  Enhanced curcumin transportation across epithelial barrier by mucus-permeable soy protein nanoparticles-mediated dual transcytosis pathways.  FOOD CHEMISTRY,  437  (137771).  [PMID:37897825]
3. Xin Chang, Chang Liu, Yu-Mo Han, Qiu-Ling Li, Bin Guo, Hu-Lin Jiang.  (2023)  Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion.  Molecular Therapy-Nucleic Acids,  32  (415-431).  [PMID:37159604]
4. Wu Wenting, Ding Quan, Zhou Zhiwei, Kuang Wenliang, Jiang Lipeng, Liu Peng, Ai Weiping, Zhu Weifeng.  (2023)  Transcellular Transport Behavior of the Intact Polymeric Mixed Micelles with Different Polymeric Ratios.  AAPS PHARMSCITECH,  24  (2): (1-16).  [PMID:36792796]
5. Hou Zhenyu, Zhou Mei, Ma Yuanyuan, Xu Xiaoxuan, Zhang Zhiqi, Lai Shiwei, Fan Wenpei, Xie Jinbing, Ju Shenghong.  (2022)  Size-changeable nanoprobes for the combined radiotherapy and photodynamic therapy of tumor.  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,  49  (8): (2655-2667).  [PMID:35536421]
6. Xiudan Wang, Junya Lu, Yuling Mao, Qinfu Zhao, Caishun Chen, Jianan Han, Meiqi Han, Huijuan Yuan, Siling Wang.  (2022)  A mutually beneficial macrophages-mediated delivery system realizing photo/immune therapy.  JOURNAL OF CONTROLLED RELEASE,  347  (14).  [PMID:35489548]
7. Mingming Song, Shuqi Dong, Xiaofei An, Wenxiang Zhang, Ning Shen, Yanbo Li, Caixia Guo, Chang Liu, Xiao Li, Siyu Chen.  (2022)  Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers.  JOURNAL OF CONTROLLED RELEASE,  345  (744).  [PMID:35381274]

References

1. Li, M., Li, S., Huang, Y., Chen, H., Zhang, S., Zhang, Z., Wu, W., Zeng, X., Zhou, B., and Li, B..  (2021)  Secreted expression of mRNA-encoded truncated ACE2 variants for SARS-CoV-2 via lipid-like nanoassemblies..  Adv. Mater. ,  34  (33): (2101707).  [PMID:]
2. Huang, Y., Yang, M., Wang, N., Li, S., Liu, Z., Li, Z., Ji, Z., and Li, B..  (2022)  Intracellular delivery of messenger RNA to macrophages with surfactant-derived lipid nanoparticles.  Mater. Today Adv.,  16  (NA): (100295 ).  [PMID:]
3. Xucan Yang, Lulu Cheng, Yile Zhao, Haoran Ma, Haitao Song, Xuanmin Yang, Kang-Nan Wang, Yanrong Zhang.  (2024)  Aggregation-induced emission-active iridium (III)-based mitochondria-targeting nanoparticle for two-photon imaging-guided photodynamic therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  659  (320).  [PMID:38176241]
4. Dan Yuan, Qi Li, Qibo Zhang, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao.  (2024)  Enhanced curcumin transportation across epithelial barrier by mucus-permeable soy protein nanoparticles-mediated dual transcytosis pathways.  FOOD CHEMISTRY,  437  (137771).  [PMID:37897825]
5. Xin Chang, Chang Liu, Yu-Mo Han, Qiu-Ling Li, Bin Guo, Hu-Lin Jiang.  (2023)  Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion.  Molecular Therapy-Nucleic Acids,  32  (415-431).  [PMID:37159604]
6. Wu Wenting, Ding Quan, Zhou Zhiwei, Kuang Wenliang, Jiang Lipeng, Liu Peng, Ai Weiping, Zhu Weifeng.  (2023)  Transcellular Transport Behavior of the Intact Polymeric Mixed Micelles with Different Polymeric Ratios.  AAPS PHARMSCITECH,  24  (2): (1-16).  [PMID:36792796]
7. Hou Zhenyu, Zhou Mei, Ma Yuanyuan, Xu Xiaoxuan, Zhang Zhiqi, Lai Shiwei, Fan Wenpei, Xie Jinbing, Ju Shenghong.  (2022)  Size-changeable nanoprobes for the combined radiotherapy and photodynamic therapy of tumor.  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,  49  (8): (2655-2667).  [PMID:35536421]
8. Xiudan Wang, Junya Lu, Yuling Mao, Qinfu Zhao, Caishun Chen, Jianan Han, Meiqi Han, Huijuan Yuan, Siling Wang.  (2022)  A mutually beneficial macrophages-mediated delivery system realizing photo/immune therapy.  JOURNAL OF CONTROLLED RELEASE,  347  (14).  [PMID:35489548]
9. Mingming Song, Shuqi Dong, Xiaofei An, Wenxiang Zhang, Ning Shen, Yanbo Li, Caixia Guo, Chang Liu, Xiao Li, Siyu Chen.  (2022)  Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers.  JOURNAL OF CONTROLLED RELEASE,  345  (744).  [PMID:35381274]

Solution Calculators