elacestrant , Estrogen receptor alpha degrader, CAS No.722533-56-4, Estrogen receptor alpha degrader

Item Number
E610092
Grouped product items
SKUSizeAvailabilityPrice Qty
E610092-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$250.90
E610092-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$880.90

Basic Description

SynonymsElacestrant | 722533-56-4 | RAD1901 | RAD-1901 | ER-306323 | Elacestrant [INN] | Elacestrant [USAN] | FM6A2627A8 | UNII-FM6A2627A8 | (6R)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol | ORSERDU | (2R)-2-(2-(Ethyl-(
Specifications & PurityMoligand™
GradeMoligand™
Action TypeDEGRADER
Mechanism of actionEstrogen receptor alpha degrader

Product Properties

ALogP6.3

Associated Targets(Human)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin VHL/Cullin-2/Estrogen receptor alpha (138 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Marburgvirus (118 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Zaire ebolavirus (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (6R)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
INCHI InChI=1S/C30H38N2O2/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3/t26-/m1/s1
InChi Key SIFNOOUKXBRGGB-AREMUKBSSA-N
Canonical SMILES CCNCCC1=CC=C(C=C1)CN(CC)C2=C(C=CC(=C2)OC)C3CCC4=C(C3)C=CC(=C4)O
Isomeric SMILES CCNCCC1=CC=C(C=C1)CN(CC)C2=C(C=CC(=C2)OC)[C@@H]3CCC4=C(C3)C=CC(=C4)O
Alternate CAS 722533-56-4
PubChem CID 23642301
MeSH Entry Terms (6R)-6-(2-(ethyl((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol;elacestrant
Molecular Weight 458.6

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Wardell SE, Nelson ER, Chao CA, Alley HM, McDonnell DP.  (2015)  Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader..  Endocr Relat Cancer,  22  (5): (713-24).  [PMID:26162914]
2. Garner F, Shomali M, Paquin D, Lyttle CR, Hattersley G.  (2015)  RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models..  Anticancer Drugs,  26  (9): (948-56).  [PMID:26164151]
3. Hattersley G, Harris AG, Simon JA, Constantine GD.  (2017)  Clinical investigation of RAD1901, a novel estrogen receptor ligand, for the treatment of postmenopausal vasomotor symptoms: a phase 2 randomized, placebo-controlled, double-blind, dose-ranging, proof-of-concept trial..  Menopause,  24  (1): (92-99).  [PMID:27575546]

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