Elimusertib (BAY-1895344) is a very potent and highly selective ATR (ataxia telangiectasia and Rad3-related) inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Serine-protein kinase ATR inhibitor
Product Description
Information
Elimusertib (BAY-1895344) is a very potent and highly selectiveATR (ataxia telangiectasia and Rad3-related)inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.
Targets
ATR (Cell-free assay) 7 nM
In vitro
BAY-1895344 inhibits tumor cell growth and viability and exhibits potent antiproliferative activity in a broad spectrum of human tumor cell lines.
In vivo
BAY 1895344 exhibits strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.
Cell Research(from reference)
Cell lines：HT-29 cells, M059J cells, 38 cancer cell lines
1.Minchom A, Aversa C, Lopez J. (2018) Dancing with the DNA damage response: next-generation anti-cancer therapeutic strategies.. Ther Adv Med Oncol, 10 (13):(1758835918786658). [PMID:30023007][10.1021/op500134e]
2.Mei L, Zhang J, He K, Zhang J. (2019) Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand.. J Hematol Oncol, 12 (1):(43). [PMID:31018854][10.1021/op500134e]
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K2211228