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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E137445-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $111.90 | |
E137445-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $426.90 |
Non-competitive and GluN2B-selective NMDA antagonist
Synonyms | Eliprodil | 119431-25-3 | Eliprodil [INN] | C20H23ClFNO | SL-820715 | alpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol | 1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanol | CHEMBL28564 | YW62A6TW29 | DTXSID1045744 | 1-Piperidineethan |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for GluN2B (formally NR2B)- over GluN2A (NR2A)- and GluN2C (NR2C)-containing receptors (IC50values are 1, > 100 and > 100μM respectively). Alsoσ1ligand (Ki= 0.0 |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | 卖完停产,不再备货 |
Product Description | Eliprodil is a non-competitive NMDA receptor antagonist which acts at the polyamine modulatory site. Eliprodil is selective for NMDA epsilon 2 (NR2B-containing receptors) over NR2A- and NR2C-containing receptors (IC50 values are 1, > 100 and > 100 μM respectively) in addition to acting as a Sigma Receptor (σ1 ligand) (Ki = 0.013 μM). Eliprodil antagonizes neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). Furthermore, Eliprodil is reported to act as a neuroprotective. |
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IUPAC Name | 1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethanol |
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INCHI | InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2 |
InChi Key | GGUSQTSTQSHJAH-UHFFFAOYSA-N |
Canonical SMILES | C1CN(CCC1CC2=CC=C(C=C2)F)CC(C3=CC=C(C=C3)Cl)O |
Isomeric SMILES | C1CN(CCC1CC2=CC=C(C=C2)F)CC(C3=CC=C(C=C3)Cl)O |
WGK Germany | 3 |
PubChem CID | 60703 |
Molecular Weight | 347.85 |
Enter Lot Number to search for COA:
Solubility | Solvent:DMSO, Max Conc. mg/mL: 8.7, Max Conc. mM: 25 |
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Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 3 |