Eliprodil - ≥98% (HPLC), high purity , CAS No.119431-25-3

Item Number

E137445

• Synonyms: ?-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol | BDBM50079387 | SL-82,0715; SL82,0715; SL 82,0715; SL-820715; SL820715; SL 820715 | Eliprodil, >=98% (HPLC), powder | HY-12881 | YW62A6TW29 | 1-Piperidineethanol, alpha-(4-chlorophenyl)-4-
• Specifications & Purity: ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for GluN2B (formally NR2B)- over GluN2A (NR2A)- and GluN2C (NR2C)-containing receptors (IC50values are 1, > 100 and > 100μM respectively). Alsoσ1ligand (Ki= 0.0
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Note: 卖完停产，不再备货

Product Description

Eliprodil is a non-competitive NMDA receptor antagonist which acts at the polyamine modulatory site. Eliprodil is selective for NMDA epsilon 2 (NR2B-containing receptors) over NR2A- and NR2C-containing receptors (IC50 values are 1, > 100 and > 100 μM respectively) in addition to acting as a Sigma Receptor (σ1 ligand) (Ki = 0.013 μM). Eliprodil antagonizes neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). Furthermore, Eliprodil is reported to act as a neuroprotective.