Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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E424149-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 |
Selective, casein kinase 2 (CK2) inhibitor
Synonyms | ellagic acid | 476-66-4 | Benzoaric acid | Elagostasine | Lagistase | Eleagic acid | Alizarine Yellow | 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione | Gallogen | Llagic acid | Acido elagico | Acidum ellagicum | Ellagicacid | Acide ellagique | Gallogen (astringent) | C.I. |
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Specifications & Purity | 2mM in DMSO |
Biochemical and Physiological Mechanisms | Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma. Contact activation in blood coagulation.Selective, ATP-competitive casein kinase 2 (CK2) inhibitor (K i = 20 nM). Exhibits a multitu |
Storage Temp | Protected from light,Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | A CK2, Topo I and II, FGR, GSK, and PKA inhibitor. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione |
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INCHI | InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H |
InChi Key | AFSDNFLWKVMVRB-UHFFFAOYSA-N |
Canonical SMILES | C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O |
Isomeric SMILES | C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O |
WGK Germany | 3 |
RTECS | DJ2620000 |
PubChem CID | 5281855 |
Molecular Weight | 302.19 |
Beilstein | 47549 |
Enter Lot Number to search for COA:
Sensitivity | Air sensitive.Light sensitive. |
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Melt Point(°C) | 360°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | DJ2620000 |
Merck Index | 3547 |
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2. Edidiong Joseph Bassey, Jun-Hu Cheng, Da-Wen Sun. (2024) Comparative elucidation of bioactive and antioxidant properties of red dragon fruit peel as affected by electromagnetic and conventional drying approaches. FOOD CHEMISTRY, 439 (138118). [PMID:38109834] [10.1016/j.foodchem.2023.138118] |
3. Sadia Munir, Wei Yue, Jinling Li, Xiaoyue Yu, Tianhao Ying, Ru Liu, Juan You, Shanbai Xiong, Yang Hu. (2023) Effects of Phenolics on the Physicochemical and Structural Properties of Collagen Hydrogel. Polymers, 15 (24): (4647). [PMID:38139899] [10.3390/polym15244647] |
4. Nan Li, Juan Zheng, Lu-Dan Yu, Yuan-Jun Tong, Xinying Gong, Yu Hou, Guosheng Chen, Jianqiao Xu, Fang Zhu, Gangfeng Ouyang. (2024) Green, mildly synthesized bismuth-based MOF for extraction of polar glucocorticoids in environmental water. JOURNAL OF HAZARDOUS MATERIALS, 461 (132477). [PMID:37716268] [10.1016/j.jhazmat.2023.132477] |
5. Yuanhang Xiao, Chunhua Wang, Jiajing Zhou, Jianhui Wu, Wei Lin. (2023) Modular design of vegetable polyphenols enables covalent bonding with collagen for eco-leather. INDUSTRIAL CROPS AND PRODUCTS, 204 (19): (117394). [PMID:20178741] [10.1016/j.indcrop.2023.117394] |
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9. Mao-Ling Luo, Hua Chen, Guo-Ying Chen, Shengpeng Wang, Yitao Wang, Feng-Qing Yang. (2023) Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening. MOLECULES, 28 (14): (5429). [PMID:37513303] [10.3390/molecules28145429] |
10. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). [PMID:37422124] [10.1016/j.jconrel.2023.07.003] |
11. Jianmin Chen, Zemin He, Sijin Yu, Xiaozhen Cai, Danhong Zhu, Yanhua Lin. (2023) Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies. IET Nanobiotechnology, 17 (4): (368-375). [PMID:37153957] [10.1049/nbt2.12135] |
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13. Minglu Zhang, Yi Zhang, Zhi-feng Cai. (2023) Selective determination of ellagic acid in aqueous solution using blue-green emissive copper nanoclusters. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 295 (122597). [PMID:36930836] [10.1016/j.saa.2023.122597] |
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15. Jiao Wu, Bingjun Han, Xiaoyu Chen, Jinglin Gao, Shan Zhao, Liping Sun, Shijie Wang. (2023) Quantification of bioactive components and evaluation of microbial community and antibacterial activity from Heterotrigona itama and Tetrigona binghami honeys. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 58 (5): (2247-2257). [PMID:] [10.1111/ijfs.16325] |
16. Linna Guo, Miao Tian, Lijuan Wang, Xin Zhou, Qianqian Wang, Lin Hao, Qiuhua Wu, Zhi Wang, Chun Wang. (2023) Synthesis of hydroxyl-functional magnetic hypercrosslinked polymer as high efficiency adsorbent for sensitively detecting neonicotinoid residues in water and lettuce samples. MICROCHEMICAL JOURNAL, 187 (108412). [PMID:] [10.1016/j.microc.2023.108412] |
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19. Xuan Huang, Chunjun Yan, Ming Lin, Changwei He, Yanfei Xu, Yukun Huang, Zheng Zhou. (2022) The effects of conjugation of walnut protein isolate with polyphenols on protein solubility, antioxidant activity, and emulsifying properties. FOOD RESEARCH INTERNATIONAL, 161 (111910). [PMID:36193000] [10.1016/j.foodres.2022.111910] |
20. Nan Chen, Hao-Xiang Gao, Qiang He, Zhi-Long Yu, Wei-Cai Zeng. (2022) Influence of structure complexity of phenolic compounds on their binding with maize starch. Food Structure-Netherlands, 33 (100286). [PMID:] [10.1016/j.foostr.2022.100286] |
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22. Song Mengmeng, Xu Zhuicheng, Han Sixuan, Sheng Xianjie, Chen Yan, Li Xinru, Su Yan, Li Qin, Shan Chenxiao, Xie Tong, Kang An. (2022) Systematic Identification of the Main Constituents from Agrimonia pilosa Ledeb. and Their Metabolites in Rats using HPLC-Q-TOF-MS/MS. PLANTA MEDICA, 88 (14): (1369-1383). [PMID:35062039] [10.1055/a-1747-6004] |
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30. Maiquan Li, Weisu Huang, Fan Jie, Mengmeng Wang, Yongheng Zhong, Qi Chen, Baiyi Lu. (2019) Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking. FOOD AND CHEMICAL TOXICOLOGY, 133 (110758). [PMID:31412289] [10.1016/j.fct.2019.110758] |
31. Qian Huang, Wei-Ming Chai, Zuo-Yuan Ma, Wei-Liang Deng, Qi-Ming Wei, Shuang Song, Zheng-Rong Zou, Yi-Yuan Peng. (2019) Antityrosinase mechanism of ellagic acid in vitro and its effect on mouse melanoma cells. JOURNAL OF FOOD BIOCHEMISTRY, 43 (11): (e12996). [PMID:31659813] [10.1111/jfbc.12996] |
32. Lili Zhong, Hong Liu, Weijia Zhang, Xu Liu, Bo Jiang, Hongxin Fei, Zhongren Sun. (2018) Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation. Experimental and Therapeutic Medicine, 16 (6): (4951-4958). [PMID:30542451] [10.3892/etm.2018.6860] |
33. Zhiqiang Chen, Ying Liu, Lijie Hao, Zhencai Zhu, Fang Li, Shufeng Liu. (2018) Reduced Graphene Oxide-Zirconium Dioxide–Thionine Nanocomposite Integrating Recognition, Amplification, and Signaling for an Electrochemical Assay of Protein Kinase Activity and Inhibitor Screening. ACS Applied Bio Materials, 1 (5): (1557–1565). [PMID:34996206] [10.1021/acsabm.8b00451] |
34. Chen Peng, Chen Fuchao, Zhou Benhong. (2018) Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. Scientific Reports, 8 (1): (1-10). [PMID:29362375] [10.1038/s41598-018-19732-0] |
35. Gaozheng Zhao, Huihui Wu, Ruilu Feng, Dongdong Wang, Pengping Xu, Peng Jiang, Kang Yang, Haibao Wang, Zhen Guo, Qianwang Chen. (2018) Novel Metal Polyphenol Framework for MR Imaging-Guided Photothermal Therapy. ACS Applied Materials & Interfaces, 10 (4): (3295–3304). [PMID:29300453] [10.1021/acsami.7b16222] |
36. Qian Li, Jun Chen, Ti Li, Chengmei Liu, Wei Liu, Jiyan Liu. (2015) Comparison of bioactivities and phenolic composition of Choerospondias axillaris peels and fleshes. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 96 (7): (2462-2471). [PMID:26249806] [10.1002/jsfa.7366] |
37. Yunlei Zhou, Mo Wang, Zhiqing Yang, Huanshun Yin, Shiyun Ai. (2015) A Phos-tag-based photoelectrochemical biosensor for assay of protein kinase activity and inhibitors. SENSORS AND ACTUATORS B-CHEMICAL, 206 (728). [PMID:] [10.1016/j.snb.2014.09.017] |
38. Huanshun Yin, Mo Wang, Bingchen Li, Zhiqing Yang, Yunlei Zhou, Shiyun Ai. (2015) A sensitive electrochemical biosensor for detection of protein kinase A activity and inhibitors based on Phos-tag and enzymatic signal amplification. BIOSENSORS & BIOELECTRONICS, 63 (26). [PMID:25048450] [10.1016/j.bios.2014.07.016] |
39. Yizhong Shen, Shaopu Liu, Jian Wang, Dan Li, Youqiu He. (2013) Determination of ellagic acid by fluorescence quenching method with glutathione capped CdTe quantum dots as the probe. Analytical Methods, 5 (13): (3228-3234). [PMID:] [10.1039/C3AY40365C] |
40. BENGUO LIU, WEI LI, LIZHI HU, JIAN ZHAO. (2012) MILD ALKALINE HYDROLYSIS IS AN EFFICIENT AND LOW-COST METHOD FOR IMPROVING THE FREE PHENOLIC CONTENT AND HEALTH BENEFIT OF POMEGRANATE PEEL EXTRACT. JOURNAL OF FOOD PROCESSING AND PRESERVATION, 37 (5): (694-700). [PMID:] [10.1111/j.1745-4549.2012.00684.x] |
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31. Qian Huang, Wei-Ming Chai, Zuo-Yuan Ma, Wei-Liang Deng, Qi-Ming Wei, Shuang Song, Zheng-Rong Zou, Yi-Yuan Peng. (2019) Antityrosinase mechanism of ellagic acid in vitro and its effect on mouse melanoma cells. JOURNAL OF FOOD BIOCHEMISTRY, 43 (11): (e12996). [PMID:31659813] [10.1111/jfbc.12996] |
32. Lili Zhong, Hong Liu, Weijia Zhang, Xu Liu, Bo Jiang, Hongxin Fei, Zhongren Sun. (2018) Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation. Experimental and Therapeutic Medicine, 16 (6): (4951-4958). [PMID:30542451] [10.3892/etm.2018.6860] |
33. Zhiqiang Chen, Ying Liu, Lijie Hao, Zhencai Zhu, Fang Li, Shufeng Liu. (2018) Reduced Graphene Oxide-Zirconium Dioxide–Thionine Nanocomposite Integrating Recognition, Amplification, and Signaling for an Electrochemical Assay of Protein Kinase Activity and Inhibitor Screening. ACS Applied Bio Materials, 1 (5): (1557–1565). [PMID:34996206] [10.1021/acsabm.8b00451] |
34. Chen Peng, Chen Fuchao, Zhou Benhong. (2018) Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. Scientific Reports, 8 (1): (1-10). [PMID:29362375] [10.1038/s41598-018-19732-0] |
35. Gaozheng Zhao, Huihui Wu, Ruilu Feng, Dongdong Wang, Pengping Xu, Peng Jiang, Kang Yang, Haibao Wang, Zhen Guo, Qianwang Chen. (2018) Novel Metal Polyphenol Framework for MR Imaging-Guided Photothermal Therapy. ACS Applied Materials & Interfaces, 10 (4): (3295–3304). [PMID:29300453] [10.1021/acsami.7b16222] |
36. Qian Li, Jun Chen, Ti Li, Chengmei Liu, Wei Liu, Jiyan Liu. (2015) Comparison of bioactivities and phenolic composition of Choerospondias axillaris peels and fleshes. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 96 (7): (2462-2471). [PMID:26249806] [10.1002/jsfa.7366] |
37. Yunlei Zhou, Mo Wang, Zhiqing Yang, Huanshun Yin, Shiyun Ai. (2015) A Phos-tag-based photoelectrochemical biosensor for assay of protein kinase activity and inhibitors. SENSORS AND ACTUATORS B-CHEMICAL, 206 (728). [PMID:] [10.1016/j.snb.2014.09.017] |
38. Huanshun Yin, Mo Wang, Bingchen Li, Zhiqing Yang, Yunlei Zhou, Shiyun Ai. (2015) A sensitive electrochemical biosensor for detection of protein kinase A activity and inhibitors based on Phos-tag and enzymatic signal amplification. BIOSENSORS & BIOELECTRONICS, 63 (26). [PMID:25048450] [10.1016/j.bios.2014.07.016] |
39. Yizhong Shen, Shaopu Liu, Jian Wang, Dan Li, Youqiu He. (2013) Determination of ellagic acid by fluorescence quenching method with glutathione capped CdTe quantum dots as the probe. Analytical Methods, 5 (13): (3228-3234). [PMID:] [10.1039/C3AY40365C] |
40. BENGUO LIU, WEI LI, LIZHI HU, JIAN ZHAO. (2012) MILD ALKALINE HYDROLYSIS IS AN EFFICIENT AND LOW-COST METHOD FOR IMPROVING THE FREE PHENOLIC CONTENT AND HEALTH BENEFIT OF POMEGRANATE PEEL EXTRACT. JOURNAL OF FOOD PROCESSING AND PRESERVATION, 37 (5): (694-700). [PMID:] [10.1111/j.1745-4549.2012.00684.x] |