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Ellipticine hydrochloride - 98%, high purity , CAS No.5081-48-1
Topo II Selective Inhibitors | Activators
Basic Description Synonyms Q27254611 | 5,11-dimethyl-6H-pyrido[4,3-b]carbazole;hydrochloride | BS-17160 | NSC71795 hydrochloride | D71154 | 5,11-Dimethyl-6H-pyrido(4,3-b)carbazole hydrochloride | BCP30117 | Ellipticine (hydrochloride) | Ellipticine hydrochloride | AC-35692 | UNII-2 Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor of DNA topoisomerase II and forms covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine Hydrochloride is a natural product isolated from the Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
Ellipticine Hydrochloride (NSC 71795, PZE) is a potent inhibitor ofDNA topoisomerase IIand forms covalent DNA adducts mediated by its oxidation withcytochromes P450 (CYP)andperoxidases. Ellipticine Hydrochloride is a natural product isolated from the Australian evergreen tree of the Apocynaceae family with antineoplastic activity.
Targets
P450 ; peroxidase ; Topo II
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 5,11-dimethyl-6H-pyrido[4,3-b]carbazole;hydrochloride INCHI InChI=1S/C17H14N2.ClH/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17;/h3-9,19H,1-2H3;1H InChi Key VSBNVARERCGCEF-UHFFFAOYSA-N Canonical SMILES CC1=C2C=CN=CC2=C(C3=C1NC4=CC=CC=C43)C.Cl Isomeric SMILES CC1=C2C=CN=CC2=C(C3=C1NC4=CC=CC=C43)C.Cl Alternate CAS 519-23-3 PubChem CID 169532 Molecular Weight 282.77
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 3 mg/mL (10.6 mM); Water: ˂1 mg/mL Ethanol: ˂1 mg/mL Sensitivity Moisture sensitive DMSO(mg / mL) Max Solubility 3 DMSO(mM) Max Solubility 10.6093291367543 Water(mg / mL) Max Solubility ˂1
Safety and Hazards(GHS) Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
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C2304489
