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Eltrombopag - ≥99%, high purity , CAS No.496775-61-2, Agonist of Thrombopoietin receptor
Basic Description Synonyms BCP9000641 | D02363 | CHEBI:85010 | EN300-1709152 | XDXWLKQMMKQXPV-UHFFFAOYSA-N | SB497115 | SB-497115 | 3'-[(2Z)- [1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid | 3'-{2-[1-( Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms An agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of Thrombopoietin receptor Note 5mg、10mg、25mg、50mg、100mg卖完停产，不再备货 Product Description Eltrombopag is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR).
Associated Targets(Human) Names and Identifiers IUPAC Name 3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid INCHI InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33) InChi Key SVOQIEJWJCQGDQ-UHFFFAOYSA-N Canonical SMILES CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C Isomeric SMILES CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C PubChem CID 135449332 Molecular Weight 442.47
Chemical and Physical Properties Solubility 25°C: DMSO 89 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 , GHS05 , GHS07 Signal Danger Hazard Statements H373: Causes damage to organs through prolonged or repeated exposure
H302: Harmful if swallowed
H318: Causes serious eye damage
H410: Very toxic to aquatic life with long lasting effects
Precautionary Statements P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P305+P354+P338: IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P317: Get emergency medical help.
P319: Get medical help if you feel unwell.
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