Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E126424-5mg | 5mg | In stock | $107.90 | |
E126424-10mg | 10mg | In stock | $195.90 | |
E126424-25mg | 25mg | In stock | $419.90 | |
E126424-50mg | 50mg | In stock | $546.90 | |
E126424-100mg | 100mg | In stock | $648.90 |
Synonyms | Tepotinib | MSC2156119 | Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]- | TEPOTINIB [WHO-DD] | Tepotinib(EMD-1214063) | MSC2156119J | AHYMHWXQRWRBKT-UHFFFAOYSA-N | compound 22 [PM |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor EMD-1214063 selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Hepatocyte growth factor receptor inhibitor |
ALogP | 3.4 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile |
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INCHI | InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3 |
InChi Key | AHYMHWXQRWRBKT-UHFFFAOYSA-N |
Canonical SMILES | CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N |
Isomeric SMILES | CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N |
PubChem CID | 25171648 |
Molecular Weight | 492.57 |
PubChem CID | 25171648 |
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CAS Registry No. | 1100598-32-0 |
RCSB PDB Ligand | 3E8 |
DrugCentral Ligand | 5424 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2229207 | Certificate of Analysis | Jun 15, 2024 | E126424 |
H2229233 | Certificate of Analysis | Jun 15, 2024 | E126424 |
H2229240 | Certificate of Analysis | Jun 15, 2024 | E126424 |
H2229241 | Certificate of Analysis | Jun 15, 2024 | E126424 |
H2229247 | Certificate of Analysis | Jun 15, 2024 | E126424 |
A2411393 | Certificate of Analysis | Aug 22, 2022 | E126424 |
A2411398 | Certificate of Analysis | Aug 22, 2022 | E126424 |
A2411399 | Certificate of Analysis | Aug 22, 2022 | E126424 |
A2411407 | Certificate of Analysis | Aug 22, 2022 | E126424 |
A2411408 | Certificate of Analysis | Aug 22, 2022 | E126424 |
A2411409 | Certificate of Analysis | Aug 22, 2022 | E126424 |
A2411433 | Certificate of Analysis | Aug 22, 2022 | E126424 |
A2411434 | Certificate of Analysis | Aug 22, 2022 | E126424 |
A2411435 | Certificate of Analysis | Aug 22, 2022 | E126424 |
A2411436 | Certificate of Analysis | Aug 22, 2022 | E126424 |
Solubility | DMSO mg/mL Water mg/mL Ethanol mg/mL;Soluble in DMSO, the highest concentration (mg/mL): 17, the highest concentration (mM): 34.51 (heated in a water bath at 50℃); soluble in Ethanol, the highest concentration (mg/mL): 6, the highest concentration (mM): 1 |
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1. Bladt F, Faden B, Friese-Hamim M, Knuehl C, Wilm C, Fittschen C, Grädler U, Meyring M, Dorsch D, Jaehrling F et al.. (2013) EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors.. Clin Cancer Res, 19 (11): (2941-51). [PMID:23553846] [10.1021/op500134e] |
2. Zhang NN, An BJ, Zhou Y, Li XS, Yan M. (2019) Synthesis, Evaluation, and Mechanism Study of New Tepotinib Derivatives as Antiproliferative Agents.. Molecules, 24 (6): (1755-70). [PMID:30934578] [10.3390/molecules24061173] |