1. Sampei Z, Igawa T, Soeda T, Okuyama-Nishida Y, Moriyama C, Wakabayashi T, Tanaka E, Muto A, Kojima T, Kitazawa T et al.. (2013) Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity.. PLoS ONE, 8 (2): (e57479). [PMID:23468998] |
2. Kitazawa T, Esaki K, Tachibana T, Ishii S, Soeda T, Muto A, Kawabe Y, Igawa T, Tsunoda H, Nogami K et al.. (2017) Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens.. Thromb Haemost, 117 (7): (1348-1357). [PMID:28451690] |
3. Muto A, Yoshihashi K, Takeda M, Kitazawa T, Soeda T, Igawa T, Sakamoto Y, Haraya K, Kawabe Y, Shima M et al.. (2014) Anti-factor IXa/X bispecific antibody (ACE910): hemostatic potency against ongoing bleeds in a hemophilia A model and the possibility of routine supplementation.. J Thromb Haemost, 12 (2): (206-213). [PMID:24735117] |
4. Oldenburg J, Mahlangu JN, Kim B, Schmitt C, Callaghan MU, Young G, Santagostino E, Kruse-Jarres R, Negrier C, Kessler C et al.. (2017) Emicizumab Prophylaxis in Hemophilia A with Inhibitors.. N Engl J Med, 377 (9): (809-818). [PMID:28691557] |
5. Yousphi AS, Bakhtiar A, Cheema MA, Nasim S, Ullah W. (2019) Acquired Hemophilia A: A Rare but Potentially Fatal Bleeding Disorder.. Cureus, 11 (8): (e5442). [PMID:31632887] |
6. Wang S, Beck R, Burd A, Blench T, Marlin F, Ayele T, Buxton S, Dagostin C, Malic M, Joshi R et al.. (2010) Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors.. J Med Chem, 53 (4): (1473-82). [PMID:20121197] |
7. Di Scipio RG, Kurachi K, Davie EW. (1978) Activation of human factor IX (Christmas factor).. J Clin Invest, 61 (6): (1528-38). [PMID:659613] |
8. Pinto DJ, Orwat MJ, Wang S, Fevig JM, Quan ML, Amparo E, Cacciola J, Rossi KA, Alexander RS, Smallwood AM, Luettgen JM, Liang L, Aungst BJ, Wright MR, Knabb RM, Wong PC, Wexler RR, Lam PY.. (2001) Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.. J Med Chem, 44 (4): (566-578). [PMID:11170646] |
9. Pinto DJ, Orwat MJ, Quan ML, Han Q, Galemmo RA, Amparo E, Wells B, Ellis C, He MY, Alexander RS, Rossi KA, Smallwood A, Wong PC, Luettgen JM, Rendina AR, Knabb RM, Mersinger L, Kettner C, Bai S, He K, Wexler RR, Lam PY.. (2006) 1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.. Bioorg Med Chem Lett, 16 (15): (4141-4147). [PMID:16730984] |
10. Wang S, Beck R, Blench T, Burd A, Buxton S, Malic M, Ayele T, Shaikh S, Chahwala S, Chander C, Holland R, Merette S, Zhao L, Blackney M, Watts A.. (2010) Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.. J Med Chem, 53 (4): (1465-1472). [PMID:20121198] |
11. Sidhu PS, Mosier PD, Zhou Q, Desai UR.. (2013) On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans.. Bioorg Med Chem Lett, 23 (1): (355-359). [PMID:23164711] |
12. Al-Horani RA, Ponnusamy P, Mehta AY, Gailani D, Desai UR.. (2013) Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa.. J Med Chem, 56 (3): (867-878). [PMID:23316863] |
13. Meneyrol J, Follmann M, Lassalle G, Wehner V, Barre G, Rousseaux T, Altenburger JM, Petit F, Bocskei Z, Schreuder H, Alet N, Herault JP, Millet L, Dol F, Florian P, Schaeffer P, Sadoun F, Klieber S, Briot C, Bono F, Herbert JM.. (2013) 5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.. J Med Chem, 56 (23): (9441-9456). [PMID:24175584] |
14. Zhang X, Glunz PW, Johnson JA, Jiang W, Jacutin-Porte S, Ladziata V, Zou Y, Phillips MS, Wurtz NR, Parkhurst B, Rendina AR, Harper TM, Cheney DL, Luettgen JM, Wong PC, Seiffert D, Wexler RR, Priestley ES.. (2016) Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex.. J Med Chem, 59 (15): (7125-7137). [PMID:27455395] |
15. Fischer PM.. (2018) Design of Small-Molecule Active-Site Inhibitors of the S1A Family Proteases as Procoagulant and Anticoagulant Drugs.. J Med Chem, 61 (9): (3799-3822). [PMID:29072911] |
16. Chen P, Zhang D, Li M, Wu Q, Lam YPY, Guo Y, Chen C, Bai N, Malhotra S, Li W, O'Connor PB, Fu H.. (2019) Discovery of novel, potent, isosteviol-based antithrombotic agents.. Eur J Med Chem, 183 (111722-111722). [PMID:31563807] |
17. Xing J, Yang L, Zhou J, Zhang H.. (2018) Design, synthesis and biological evaluation of anthranilamide derivatives as potential factor Xa (fXa) inhibitors.. Bioorg Med Chem, 26 (23-24): (5987-5999). [PMID:30446438] |
18. Hoofnagle, J H JH, Gerety, R J RJ, Thiel, J J and Barker, L F LF.. (1976) The prevalence of hepatitis B surface antigen in commercially prepared plasma products.. The Journal of laboratory and clinical medicine, [PMID:932529] |
19. Baron, M M and 7 more authors.. (1992) The three-dimensional structure of the first EGF-like module of human factor IX: comparison with EGF and TGF-alpha.. Protein science : a publication of the Protein Society, [PMID:1304885] |
20. Ludwig, M M and 6 more authors.. (1992) Hemophilia B caused by five different nondeletion mutations in the protease domain of factor IX.. Blood, (1): [PMID:1346975] |
21. Nishimura, H H, Takao, T T, Hase, S S, Shimonishi, Y Y and Iwanaga, S S.. (1992) Human factor IX has a tetrasaccharide O-glycosidically linked to serine 61 through the fucose residue.. The Journal of biological chemistry, (5): [PMID:1517205] |
22. Taylor, S A SA and 5 more authors.. (1992) Characterization of the original Christmas disease mutation (cysteine 206----serine): from clinical recognition to molecular pathogenesis.. Thrombosis and haemostasis, (23): [PMID:1615485] |
23. and Sommer, S S SS.. (1992) Assessing the underlying pattern of human germline mutations: lessons from the factor IX gene.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, [PMID:1634040] |
24. Huang, L H LH, Cheng, H H, Pardi, A A, Tam, J P JP and Sweeney, W V WV.. (1991) Sequence-specific 1H NMR assignments, secondary structure, and location of the calcium binding site in the first epidermal growth factor like domain of blood coagulation factor IX.. Biochemistry, (30): [PMID:1854745] |
25. Sarkar, G G, Cassady, J D JD, Pyeritz, R E RE, Gilchrist, G S GS and Sommer, S S SS.. (1991) Isoleucine397 is changed to threonine in two females with hemophilia B.. Nucleic acids research, (11): [PMID:1902289] |
26. Miyata, T T and 9 more authors.. (1991) Factor IX Amagasaki: a new mutation in the catalytic domain resulting in the loss of both coagulant and esterase activities.. Biochemistry, (26): [PMID:1958666] |
27. Iwanaga, S S and 5 more authors.. (1990) A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z.. Advances in experimental medicine and biology, [PMID:2129367] |
28. Bertina, R M RM and 6 more authors.. (1990) Mutations in hemophilia Bm occur at the Arg180-Val activation site or in the catalytic domain of factor IX.. The Journal of biological chemistry, (5): [PMID:2162822] |
29. Wang, N S NS, Zhang, M M, Thompson, A R AR and Chen, S H SH.. (1990) Factor IX Chongqing: a new mutation in the calcium-binding domain of factor IX resulting in severe hemophilia B.. Thrombosis and haemostasis, (19): [PMID:2339358] |
30. Taylor, S A SA, Liddell, M B MB, Peake, I R IR, Bloom, A L AL and Lillicrap, D P DP.. (1990) A mutation adjacent to the beta cleavage site of factor IX (valine 182 to leucine) results in mild haemophilia Bm.. British journal of haematology, [PMID:2372509] |
31. Chen, S H SH, Thompson, A R AR, Zhang, M M and Scott, C R CR.. (1989) Three point mutations in the factor IX genes of five hemophilia B patients. Identification strategy using localization by altered epitopes in their hemophilic proteins.. The Journal of clinical investigation, [PMID:2472424] |
32. Nishimura, H H and 7 more authors.. (1989) Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z.. The Journal of biological chemistry, (5): [PMID:2511201] |
33. Suehiro, K K and 9 more authors.. (1989) Blood clotting factor IX BM Nagoya. Substitution of arginine 180 by tryptophan and its activation by alpha-chymotrypsin and rat mast cell chymase.. The Journal of biological chemistry, (15): [PMID:2592373] |
34. Monroe, D M DM and 6 more authors.. (1989) Functional consequences of an arginine180 to glutamine mutation in factor IX Hilo.. Blood, (1): [PMID:2713493] |
35. Attree, O O and 5 more authors.. (1989) Mutations in the catalytic domain of human coagulation factor IX: rapid characterization by direct genomic sequencing of DNA fragments displaying an altered melting behavior.. Genomics, [PMID:2714791] |
36. Ware, J J and 7 more authors.. (1989) Factor IX San Dimas. Substitution of glutamine for Arg-4 in the propeptide leads to incomplete gamma-carboxylation and altered phospholipid binding properties.. The Journal of biological chemistry, (5): [PMID:2738071] |
37. Green, P M PM, Bentley, D R DR, Mibashan, R S RS, Nilsson, I M IM and Giannelli, F F.. (1989) Molecular pathology of haemophilia B.. The EMBO journal, [PMID:2743975] |
38. Sakai, T T and 7 more authors.. (1989) Blood clotting factor IX Kashihara: amino acid substitution of valine-182 by phenylalanine.. Journal of biochemistry, [PMID:2753873] |
39. Koeberl, D D DD, Bottema, C D CD, Buerstedde, J M JM and Sommer, S S SS.. (1989) Functionally important regions of the factor IX gene have a low rate of polymorphism and a high rate of mutation in the dinucleotide CpG.. American journal of human genetics, [PMID:2773937] |
40. Liddell, M B MB and 5 more authors.. (1989) Factor IX Cardiff: a variant factor IX protein that shows abnormal activation is caused by an arginine to cysteine substitution at position 145.. British journal of haematology, [PMID:2775660] |
41. Yoshitake, S S, Schach, B G BG, Foster, D C DC, Davie, E W EW and Kurachi, K K.. (1985) Nucleotide sequence of the gene for human factor IX (antihemophilic factor B).. Biochemistry, (2): [PMID:2994716] |
42. Bentley, A K AK, Rees, D J DJ, Rizza, C C and Brownlee, G G GG.. (1986) Defective propeptide processing of blood clotting factor IX caused by mutation of arginine to glutamine at position -4.. Cell, (9): [PMID:3009023] |
43. Sugimoto, M M and 6 more authors.. (1988) Blood clotting factor IX Niigata: substitution of alanine-390 by valine in the catalytic domain.. Journal of biochemistry, [PMID:3243764] |
44. Stoflet, E S ES, Koeberl, D D DD, Sarkar, G G and Sommer, S S SS.. (1988) Genomic amplification with transcript sequencing.. Science (New York, N.Y.), (29): [PMID:3340835] |
45. Ware, J J, Davis, L L, Frazier, D D, Bajaj, S P SP and Stafford, D W DW.. (1988) Genetic defect responsible for the dysfunctional protein: factor IXLong Beach.. Blood, [PMID:3401602] |
46. Davis, L M LM, McGraw, R A RA, Ware, J L JL, Roberts, H R HR and Stafford, D W DW.. (1987) Factor IXAlabama: a point mutation in a clotting protein results in hemophilia B.. Blood, [PMID:3790720] |
47. McGraw, R A RA and 6 more authors.. (1985) Evidence for a prevalent dimorphism in the activation peptide of human coagulation factor IX.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:3857619] |
48. Jagadeeswaran, P P, Lavelle, D E DE, Kaul, R R, Mohandas, T T and Warren, S T ST.. (1984) Isolation and characterization of human factor IX cDNA: identification of Taq I polymorphism and regional assignment.. Somatic cell and molecular genetics, [PMID:6089357] |
49. Anson, D S DS and 6 more authors.. (1984) The gene structure of human anti-haemophilic factor IX.. The EMBO journal, [PMID:6329734] |
50. Prince, A M AM and 5 more authors.. (1984) Inactivation of hepatitis B and Hutchinson strain non-A, non-B hepatitis viruses by exposure to Tween 80 and ether.. Vox sanguinis, [PMID:6422634] |
51. and Chavin, S I SI.. (1984) Factor VIII: structure and function in blood clotting.. American journal of hematology, [PMID:6424437] |
52. Morita, T T, Isaacs, B S BS, Esmon, C T CT and Johnson, A E AE.. (1984) Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid.. The Journal of biological chemistry, (10): [PMID:6425296] |
53. Noyes, C M CM, Griffith, M J MJ, Roberts, H R HR and Lundblad, R L RL.. (1983) Identification of the molecular defect in factor IX Chapel Hill: substitution of histidine for arginine at position 145.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6603618] |
54. Jaye, M M and 7 more authors.. (1983) Isolation of a human anti-haemophilic factor IX cDNA clone using a unique 52-base synthetic oligonucleotide probe deduced from the amino acid sequence of bovine factor IX.. Nucleic acids research, (25): [PMID:6687940] |
55. McMullen, B A BA, Fujikawa, K K and Kisiel, W W.. (1983) The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens.. Biochemical and biophysical research communications, (30): [PMID:6688526] |
56. Kurachi, K K and Davie, E W EW.. (1982) Isolation and characterization of a cDNA coding for human factor IX.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:6959130] |
57. Freedman, S J SJ, Furie, B C BC, Furie, B B and Baleja, J D JD.. (1995) Structure of the calcium ion-bound gamma-carboxyglutamic acid-rich domain of factor IX.. Biochemistry, (26): [PMID:7547952] |
58. Rao, Z Z and 5 more authors.. (1995) The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions.. Cell, (14): [PMID:7606779] |
59. Freedman, S J SJ, Furie, B C BC, Furie, B B and Baleja, J D JD.. (1995) Structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor IX by two-dimensional NMR spectroscopy.. The Journal of biological chemistry, (7): [PMID:7713897] |
60. Cağlayan, S H SH, Vielhaber, E E, Gürsel, T T, Aktuğlu, G G and Sommer, S S SS.. (1994) Identification of mutations in four hemophilia B patients of Turkish origin, including a novel deletion of base 6411.. Human mutation, [PMID:7981722] |
61. Aguilar-Martinez, P P and 5 more authors.. (1994) Factor IX gene mutations causing haemophilia B: comparison of SSC screening versus systematic DNA sequencing and diagnostic applications.. Human genetics, [PMID:8076946] |
62. Agarwala, K L KL and 6 more authors.. (1994) Activation peptide of human factor IX has oligosaccharides O-glycosidically linked to threonine residues at 159 and 169.. Biochemistry, (3): [PMID:8172892] |
63. Aguilar-Martinez, P P and 5 more authors.. (1994) A novel mutation (Val-373 to Glu) in the catalytic domain of factor IX, resulting in moderately/severe hemophilia B in a southern French patient.. Human mutation, [PMID:8199596] |
64. de la Salle, C C and 6 more authors.. (1993) A deletion located in the 3' non translated part of the factor IX gene responsible for mild haemophilia B.. Thrombosis and haemostasis, (2): [PMID:8236150] |
65. David, D D and 5 more authors.. (1993) Single-strand conformation polymorphism (SSCP) analysis of the molecular pathology of hemophilia B.. Human mutation, [PMID:8257988] |
66. de la Salle, C C and 9 more authors.. (1993) The Arg-4 mutant factor IX Strasbourg 2 shows a delayed activation by factor XIa.. Nouvelle revue francaise d'hematologie, [PMID:8295821] |
67. Giannelli, F F and 9 more authors.. (1993) Haemophilia B: database of point mutations and short additions and deletions--fourth edition, 1993.. Nucleic acids research, (1): [PMID:8392713] |
68. Freedman, S J SJ and 5 more authors.. (1996) Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX.. The Journal of biological chemistry, (5): [PMID:8663165] |
69. Wulff, K K, Schröder, W W, Wehnert, M M and Herrmann, F H FH.. (1995) Twenty-five novel mutations of the factor IX gene in haemophilia B.. Human mutation, [PMID:8680410] |
70. Chu, K K, Wu, S M SM, Stanley, T T, Stafford, D W DW and High, K A KA.. (1996) A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism.. The Journal of clinical investigation, (1): [PMID:8833911] |
71. Li, L L and 8 more authors.. (1997) Refinement of the NMR solution structure of the gamma-carboxyglutamic acid domain of coagulation factor IX using molecular dynamics simulation with initial Ca2+ positions determined by a genetic algorithm.. Biochemistry, (25): [PMID:9047312] |
72. Wojcik, E G EG, Van Den Berg, M M, Poort, S R SR and Bertina, R M RM.. (1997) Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa.. The Biochemical journal, (1): [PMID:9169594] |
73. Cağlayan, S H SH, Gökmen, Y Y, Aktuğlu, G G, Gürgey, A A and Sommer, S S SS.. (1997) Mutations associated with hemophilia B in Turkish patients.. Human mutation, [PMID:9222764] |
74. David, D D, Moreira, I I, Morais, S S and de Deus, G G.. (1998) Five novel factor IX mutations in unrelated hemophilia B patients.. Human mutation, [PMID:9452115] |
75. Chan, V V, Chan, V W VW, Yip, B B, Chim, C S CS and Chan, T K TK.. (1998) Hemophilia B in a female carrier due to skewed inactivation of the normal X-chromosome.. American journal of hematology, [PMID:9590153] |
76. Heit, J A JA and 8 more authors.. (1998) Germline mutations in Peruvian patients with hemophilia B: pattern of mutation in AmerIndians is similar to the putative endogenous germline pattern.. Human mutation, [PMID:9600455] |
77. Montejo, J M JM, Magallón, M M, Tizzano, E E and Solera, J J.. (1999) Identification of twenty-one new mutations in the factor IX gene by SSCP analysis.. Human mutation, [PMID:10094553] |
78. Hopfner, K P KP and 8 more authors.. (1999) Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.. Structure (London, England : 1993), (15): [PMID:10467148] |
79. Wulff, K K, Bykowska, K K, Lopaciuk, S S and Herrmann, F H FH.. (1999) Molecular analysis of hemophilia B in Poland: 12 novel mutations of the factor IX gene.. Acta biochimica Polonica, [PMID:10698280] |
80. Vidal, F F, Farssac, E E, Altisent, C C, Puig, L L and Gallardo, D D.. (2000) Factor IX gene sequencing by a simple and sensitive 15-hour procedure for haemophilia B diagnosis: identification of two novel mutations.. British journal of haematology, [PMID:11122099] |
81. Arruda, V R VR and 10 more authors.. (2001) Posttranslational modifications of recombinant myotube-synthesized human factor IX.. Blood, (1): [PMID:11133752] |
82. Onay, U Venüs UV and 7 more authors.. (2003) Molecular pathology of haemophilia B in Turkish patients: identification of a large deletion and 33 independent point mutations.. British journal of haematology, [PMID:12588353] |
83. Espinós, Carmen C, Casaña, Pilar P, Haya, Saturnino S, Cid, Ana R AR and Aznar, Jos A JA.. (2003) Molecular analyses in hemophilia B families: identification of six new mutations in the factor IX gene.. Haematologica, [PMID:12604421] |
84. Huang, Mingdong M, Furie, Barbara C BC and Furie, Bruce B.. (2004) Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody.. The Journal of biological chemistry, (2): [PMID:14722079] |
85. Ross, Mark T MT and 281 more authors.. (2005) The DNA sequence of the human X chromosome.. Nature, (17): [PMID:15772651] |
86. Simioni, Paolo P and 9 more authors.. (2009) X-linked thrombophilia with a mutant factor IX (factor IX Padua).. The New England journal of medicine, (22): [PMID:19846852] |
87. Zögg, Thomas T and Brandstetter, Hans H.. (2009) Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa.. Structure (London, England : 1993), (9): [PMID:20004170] |
88. Saini, S S and 9 more authors.. (2015) Genetic determinants of immunogenicity to factor IX during the treatment of haemophilia B.. Haemophilia : the official journal of the World Federation of Hemophilia, [PMID:25470321] |
89. Shima, Midori M and 9 more authors.. (2016) Factor VIII-Mimetic Function of Humanized Bispecific Antibody in Hemophilia A.. The New England journal of medicine, (26): [PMID:27223146] |
90. Pezeshkpoor, Behnaz B and 9 more authors.. (2018) Variants in FIX propeptide associated with vitamin K antagonist hypersensitivity: functional analysis and additional data confirming the common founder mutations.. Annals of hematology, [PMID:29450643] |
91. Cargill, M M and 17 more authors.. (1999) Characterization of single-nucleotide polymorphisms in coding regions of human genes.. Nature genetics, [PMID:10391209] |