Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E106692-100mg | 100mg | In stock | $88.90 | |
E106692-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $198.90 | |
E106692-500mg | 500mg | In stock | $357.90 | |
E106692-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $441.90 | |
E106692-5g | 5g | In stock | $1,987.90 | |
E106692-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $3,578.90 | |
E106692-25g | 25g | In stock | $8,050.90 |
Potent 11β-HSD1 inhibitor. Antioxidant agent.
Synonyms | emodin | 518-82-1 | Emodol | Frangula emodin | Schuttgelb | Rheum emodin | 1,3,8-trihydroxy-6-methylanthracene-9,10-dione | Archin | Frangulic acid | 3-Methyl-1,6,8-trihydroxyanthraquinone | Persian Berry Lake | 6-Methyl-1,3,8-trihydroxyanthraquinone | C.I. Natural Yellow 14 | 1,3 |
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Specifications & Purity | ≥90%(HPLC) |
Biochemical and Physiological Mechanisms | Emodin is a potent Lck (p56lck tyrosine kinase) inhibitor (IC50 = 18.5 μM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 μM). Emodin has been shown to suppress HER2/neu tyrosine kinase activity in HER2/neu |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A potent p56lck tyrosine kinase inhibitor shown to suppress HER2/neu tyrosine kinase activity. |
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Pubchem Sid | 488179752 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179752 |
IUPAC Name | 1,3,8-trihydroxy-6-methylanthracene-9,10-dione |
INCHI | InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3 |
InChi Key | RHMXXJGYXNZAPX-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O |
Isomeric SMILES | CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O |
PubChem CID | 3220 |
Molecular Weight | 270.24 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2322017 | Certificate of Analysis | Aug 28, 2023 | E106692 |
F1515102 | Certificate of Analysis | Mar 08, 2023 | E106692 |
B2303379 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303380 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303387 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303388 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303390 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303392 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303393 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303428 | Certificate of Analysis | Feb 10, 2023 | E106692 |
K2203210 | Certificate of Analysis | Nov 05, 2022 | E106692 |
J1818077 | Certificate of Analysis | Aug 10, 2022 | E106692 |
J1818079 | Certificate of Analysis | Aug 10, 2022 | E106692 |
B2422034 | Certificate of Analysis | Aug 27, 2021 | E106692 |
Solubility | Soluble in ethanol, sodium carbonate solution, DMSO (1 mg/ml), aqueous alkali, 1eq. NaOH (100 mM), ammonium hydroxide (10 mg/ml), ether, chloroform, benzene , and THF. Insoluble in water. |
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Sensitivity | Light,Air sensitive |
Melt Point(°C) | 256-257°C |
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
Merck Index | 3561 |
1. Yan Zhou, Yang Hu, Bin Zhu, Lei Liu, Jiong Chen. (2024) Emodin modulates the host antiviral response of fish against spring viremia of carp virus infection. AQUACULTURE, 580 (740347). [PMID:3011602] |
2. Shanshan Dai, Yunxuan Chen, Xiaoxi Fan, Jibo Han, Lingfeng Zhong, Yucong Zhang, Qingran Liu, Jiahui Lin, Weijian Huang, Lan Su, Zhouqing Huang, Bozhi Ye. (2023) Emodin attenuates cardiomyocyte pyroptosis in doxorubicin-induced cardiotoxicity by directly binding to GSDMD. PHYTOMEDICINE, (24): (155105). [PMID:37801893] |
3. Cao Xia, Deng Tianwen, Zhu Qin, Wang Jianping, Shi Wenwan, Liu Qi, Yu Qintong, Deng Wenwen, Yu Jiangnan, Wang Qilong, Xiao Gao, Xu Ximing. (2023) Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy. AAPS PHARMSCITECH, 24 (6): (1-17). [PMID:37380936] |
4. Rongkun Zhu, Zengcheng Du, Mingfang Zhu, Huanru Liang, Shumei Wang, Qing Zhou, Rui Li, Yulan Li, Chaoying Zeng, Wenhao Liu, Qiqing Chen. (2023) Molecularly imprinted polymers embedded with double perovskite quantum dots: A ratiometric fluorescence sensor for visible and fluorescent determination of Rhein. CHEMICAL ENGINEERING JOURNAL, 468 (143618). [PMID:] |
5. Peiyuan Li, Fangzhou Wen, Hongjun Yan, Qiuting Xu, Wei Su. (2023) Antimicrobial activity of Emodin in combination with visible light against Escherichia coli and Staphylococcus aureus: Applications for food safety technology. LWT-FOOD SCIENCE AND TECHNOLOGY, 181 (114750). [PMID:] |
6. Senlin Hou, Quancheng Liu, Hu Deng, Jun He, Wei Zhao, Zhixiang Wu, Qi Zhang, Liping Shang. (2023) Identification and low-frequency vibrational analysis of three free anthraquinones via terahertz spectroscopy. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 293 (122439). [PMID:36773425] |
7. Zhao Jieyun, Su Xiaowei, Jiang Lina, Ren Yuanlin, Liu Xiaohui, Cheng Chunzu. (2023) A sustainable approach to enhance flame retardant, antibacterial and UV resistance of lyocell fabrics treated with luffa phosphate derivatives and emodin. CELLULOSE, 30 (2): (1265-1285). [PMID:] |
8. Zhenming Gao, Jidong Sui, Rong Fan, Weikun Qu, Xuepeng Dong, Deguang Sun. (2022) Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling. Drug Design Development and Therapy, [PMID:32546964] |
9. Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin, Juan Shen. (2022) Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization. EUROPEAN JOURNAL OF PHARMACOLOGY, 936 (175329). [PMID:36341884] |
10. Cao Xia, He Qing, Adu-Frimpong Michael, Shen Xinyi, Rong Wanjing, Li Xiaoxiao, Zhang Jian, Xia Xiaoli, Shi Feng, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing. (2022) Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity. AAPS PHARMSCITECH, 23 (7): (1-13). [PMID:36207561] |
11. Bozhi Ye, Xudong Chen, Shanshan Dai, Jibo Han, Xiaohe Liang, Shuang Lin, Xueli Cai, Zhouqing Huang, Weijian Huang. (2022) Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes. Drug Design Development and Therapy, [PMID:30988600] |
12. Tingting Lin, Ben Chen, Liqun Fang, Haibo You, Chu Chu, Qingsong Shao, Shengqiang Tong. (2022) Solvent strength of organic phase for two biphasic solvent systems in high speed countercurrent chromatography. JOURNAL OF CHROMATOGRAPHY A, 1680 (463422). [PMID:36037578] |
13. Dan Xiu, Sibo Zhao, Zhenhua Li, Yanan Xu, Yao Wang, Zhijun Zhu, Min Zhang, Christopher D. Snow, Laurence A. Belfiore, Jianguo Tang. (2022) Conditionally designed luminescent DNA crystals doped by Ln3+(Eu3+/Tb3+) complexes or fluorescent proteins with smart drug sensing property. Journal of Materials Chemistry B, 10 (34): (6443-6452). [PMID:35703105] |
14. Shuang Luo, Jinrong He, Shaowei Huang, Xiaojing Wang, Yulin Su, Yanyang Li, Yanping Chen, Guanghua Yang, Bin Huang, Shaoju Guo, Lian Zhou, Xia Luo. (2022) Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe. PHYTOMEDICINE, 104 (154106). [PMID:35728384] |
15. Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu. (2022) Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis. Frontiers in Pharmacology, 13 (842720). [PMID:35392552] |
16. Ying Xu, Xuan Yu, Jiaqi Gui, Yiqun Wan, Jinping Chen, Ting Tan, Fan Liu, Lan Guo. (2022) Ultrasonic Solvent Extraction Followed by Dispersive Solid Phase Extraction (d-SPE) Cleanup for the Simultaneous Determination of Five Anthraquinones in Polygonum multiflorum by UHPLC-PDA. Foods, 11 (3): (386). [PMID:35159536] |
17. Jinfeng Liu, Liang Ning. (2021) Protective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway. Bioengineered, 12 (2): (10246-10253). [PMID:34839778] |
18. Dan Tang,Jia-Xiao Zhu,An-Guo Wu,You-Hua Xu,Ting-Ting Duan,Zhao-Guang Zheng,Ru-Shang Wang,Dan Li,Quan Zhu. (2013-03-16) Pre-column incubation followed by fast liquid chromatography analysis for rapid screening of natural methylglyoxal scavengers directly from herbal medicines: case study of Polygonum cuspidatum.. Journal of chromatography. A, 1286 (102-110). [PMID:23489496] |
1. Yan Zhou, Yang Hu, Bin Zhu, Lei Liu, Jiong Chen. (2024) Emodin modulates the host antiviral response of fish against spring viremia of carp virus infection. AQUACULTURE, 580 (740347). [PMID:3011602] |
2. Shanshan Dai, Yunxuan Chen, Xiaoxi Fan, Jibo Han, Lingfeng Zhong, Yucong Zhang, Qingran Liu, Jiahui Lin, Weijian Huang, Lan Su, Zhouqing Huang, Bozhi Ye. (2023) Emodin attenuates cardiomyocyte pyroptosis in doxorubicin-induced cardiotoxicity by directly binding to GSDMD. PHYTOMEDICINE, (24): (155105). [PMID:37801893] |
3. Cao Xia, Deng Tianwen, Zhu Qin, Wang Jianping, Shi Wenwan, Liu Qi, Yu Qintong, Deng Wenwen, Yu Jiangnan, Wang Qilong, Xiao Gao, Xu Ximing. (2023) Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy. AAPS PHARMSCITECH, 24 (6): (1-17). [PMID:37380936] |
4. Rongkun Zhu, Zengcheng Du, Mingfang Zhu, Huanru Liang, Shumei Wang, Qing Zhou, Rui Li, Yulan Li, Chaoying Zeng, Wenhao Liu, Qiqing Chen. (2023) Molecularly imprinted polymers embedded with double perovskite quantum dots: A ratiometric fluorescence sensor for visible and fluorescent determination of Rhein. CHEMICAL ENGINEERING JOURNAL, 468 (143618). [PMID:] |
5. Peiyuan Li, Fangzhou Wen, Hongjun Yan, Qiuting Xu, Wei Su. (2023) Antimicrobial activity of Emodin in combination with visible light against Escherichia coli and Staphylococcus aureus: Applications for food safety technology. LWT-FOOD SCIENCE AND TECHNOLOGY, 181 (114750). [PMID:] |
6. Senlin Hou, Quancheng Liu, Hu Deng, Jun He, Wei Zhao, Zhixiang Wu, Qi Zhang, Liping Shang. (2023) Identification and low-frequency vibrational analysis of three free anthraquinones via terahertz spectroscopy. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 293 (122439). [PMID:36773425] |
7. Zhao Jieyun, Su Xiaowei, Jiang Lina, Ren Yuanlin, Liu Xiaohui, Cheng Chunzu. (2023) A sustainable approach to enhance flame retardant, antibacterial and UV resistance of lyocell fabrics treated with luffa phosphate derivatives and emodin. CELLULOSE, 30 (2): (1265-1285). [PMID:] |
8. Zhenming Gao, Jidong Sui, Rong Fan, Weikun Qu, Xuepeng Dong, Deguang Sun. (2022) Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling. Drug Design Development and Therapy, [PMID:32546964] |
9. Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin, Juan Shen. (2022) Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization. EUROPEAN JOURNAL OF PHARMACOLOGY, 936 (175329). [PMID:36341884] |
10. Cao Xia, He Qing, Adu-Frimpong Michael, Shen Xinyi, Rong Wanjing, Li Xiaoxiao, Zhang Jian, Xia Xiaoli, Shi Feng, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing. (2022) Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity. AAPS PHARMSCITECH, 23 (7): (1-13). [PMID:36207561] |
11. Bozhi Ye, Xudong Chen, Shanshan Dai, Jibo Han, Xiaohe Liang, Shuang Lin, Xueli Cai, Zhouqing Huang, Weijian Huang. (2022) Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes. Drug Design Development and Therapy, [PMID:30988600] |
12. Tingting Lin, Ben Chen, Liqun Fang, Haibo You, Chu Chu, Qingsong Shao, Shengqiang Tong. (2022) Solvent strength of organic phase for two biphasic solvent systems in high speed countercurrent chromatography. JOURNAL OF CHROMATOGRAPHY A, 1680 (463422). [PMID:36037578] |
13. Dan Xiu, Sibo Zhao, Zhenhua Li, Yanan Xu, Yao Wang, Zhijun Zhu, Min Zhang, Christopher D. Snow, Laurence A. Belfiore, Jianguo Tang. (2022) Conditionally designed luminescent DNA crystals doped by Ln3+(Eu3+/Tb3+) complexes or fluorescent proteins with smart drug sensing property. Journal of Materials Chemistry B, 10 (34): (6443-6452). [PMID:35703105] |
14. Shuang Luo, Jinrong He, Shaowei Huang, Xiaojing Wang, Yulin Su, Yanyang Li, Yanping Chen, Guanghua Yang, Bin Huang, Shaoju Guo, Lian Zhou, Xia Luo. (2022) Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe. PHYTOMEDICINE, 104 (154106). [PMID:35728384] |
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