Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E106692-100mg | 100mg | In stock | $88.90 | |
E106692-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $198.90 | |
E106692-500mg | 500mg | In stock | $357.90 | |
E106692-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $441.90 | |
E106692-5g | 5g | In stock | $1,987.90 | |
E106692-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $3,578.90 | |
E106692-25g | 25g | In stock | $8,050.90 |
Potent 11β-HSD1 inhibitor. Antioxidant agent.
Synonyms | EMO | Frangula emodin | MEGxp0_000460 | 1,3,8-Trihydroxy-6-methylanthraquinone | C.I. Natural Yellow 14 | Lopac-E-7881 | Anthraquinone,3,8-trihydroxy-6-methyl- | BDBM11318 | KBio2_005068 | SR-01000075615 | EMODIN [USP-RS] | rheum emodium | 1f0q | 3bqc | 3 |
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Specifications & Purity | ≥90%(HPLC) |
Biochemical and Physiological Mechanisms | Emodin is a potent Lck (p56lck tyrosine kinase) inhibitor (IC50 = 18.5 μM). Selectively blocks the growth of v-ras transformed human bronchial epithelial cells (IC50 = 15 μM). Emodin has been shown to suppress HER2/neu tyrosine kinase activity in HER2/neu |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A potent p56lck tyrosine kinase inhibitor shown to suppress HER2/neu tyrosine kinase activity. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179752 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179752 |
IUPAC Name | 1,3,8-trihydroxy-6-methylanthracene-9,10-dione |
INCHI | InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3 |
InChi Key | RHMXXJGYXNZAPX-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O |
Isomeric SMILES | CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O |
PubChem CID | 3220 |
Molecular Weight | 270.24 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2322017 | Certificate of Analysis | Aug 28, 2023 | E106692 |
F1515102 | Certificate of Analysis | Mar 08, 2023 | E106692 |
B2303379 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303380 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303387 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303388 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303390 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303392 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303393 | Certificate of Analysis | Feb 10, 2023 | E106692 |
B2303428 | Certificate of Analysis | Feb 10, 2023 | E106692 |
K2203210 | Certificate of Analysis | Nov 05, 2022 | E106692 |
J1818077 | Certificate of Analysis | Aug 10, 2022 | E106692 |
J1818079 | Certificate of Analysis | Aug 10, 2022 | E106692 |
B2422034 | Certificate of Analysis | Aug 27, 2021 | E106692 |
K2425050 | Certificate of Analysis | Aug 27, 2021 | E106692 |
Solubility | Soluble in ethanol, sodium carbonate solution, DMSO (1 mg/ml), aqueous alkali, 1eq. NaOH (100 mM), ammonium hydroxide (10 mg/ml), ether, chloroform, benzene , and THF. Insoluble in water. |
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Sensitivity | Light,Air sensitive |
Melt Point(°C) | 256-257°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
Merck Index | 3561 |
1. Yan Zhou, Yang Hu, Bin Zhu, Lei Liu, Jiong Chen. (2024) Emodin modulates the host antiviral response of fish against spring viremia of carp virus infection. AQUACULTURE, 580 (740347). [PMID:3011602] |
2. Shanshan Dai, Yunxuan Chen, Xiaoxi Fan, Jibo Han, Lingfeng Zhong, Yucong Zhang, Qingran Liu, Jiahui Lin, Weijian Huang, Lan Su, Zhouqing Huang, Bozhi Ye. (2023) Emodin attenuates cardiomyocyte pyroptosis in doxorubicin-induced cardiotoxicity by directly binding to GSDMD. PHYTOMEDICINE, (24): (155105). [PMID:37801893] |
3. Cao Xia, Deng Tianwen, Zhu Qin, Wang Jianping, Shi Wenwan, Liu Qi, Yu Qintong, Deng Wenwen, Yu Jiangnan, Wang Qilong, Xiao Gao, Xu Ximing. (2023) Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy. AAPS PHARMSCITECH, 24 (6): (1-17). [PMID:37380936] |
4. Rongkun Zhu, Zengcheng Du, Mingfang Zhu, Huanru Liang, Shumei Wang, Qing Zhou, Rui Li, Yulan Li, Chaoying Zeng, Wenhao Liu, Qiqing Chen. (2023) Molecularly imprinted polymers embedded with double perovskite quantum dots: A ratiometric fluorescence sensor for visible and fluorescent determination of Rhein. CHEMICAL ENGINEERING JOURNAL, 468 (143618). [PMID:] |
5. Peiyuan Li, Fangzhou Wen, Hongjun Yan, Qiuting Xu, Wei Su. (2023) Antimicrobial activity of Emodin in combination with visible light against Escherichia coli and Staphylococcus aureus: Applications for food safety technology. LWT-FOOD SCIENCE AND TECHNOLOGY, 181 (114750). [PMID:] |
6. Senlin Hou, Quancheng Liu, Hu Deng, Jun He, Wei Zhao, Zhixiang Wu, Qi Zhang, Liping Shang. (2023) Identification and low-frequency vibrational analysis of three free anthraquinones via terahertz spectroscopy. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 293 (122439). [PMID:36773425] |
7. Zhao Jieyun, Su Xiaowei, Jiang Lina, Ren Yuanlin, Liu Xiaohui, Cheng Chunzu. (2023) A sustainable approach to enhance flame retardant, antibacterial and UV resistance of lyocell fabrics treated with luffa phosphate derivatives and emodin. CELLULOSE, 30 (2): (1265-1285). [PMID:] |
8. Zhenming Gao, Jidong Sui, Rong Fan, Weikun Qu, Xuepeng Dong, Deguang Sun. (2022) Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling. Drug Design Development and Therapy, [PMID:32546964] |
9. Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin, Juan Shen. (2022) Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization. EUROPEAN JOURNAL OF PHARMACOLOGY, 936 (175329). [PMID:36341884] |
10. Cao Xia, He Qing, Adu-Frimpong Michael, Shen Xinyi, Rong Wanjing, Li Xiaoxiao, Zhang Jian, Xia Xiaoli, Shi Feng, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing. (2022) Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity. AAPS PHARMSCITECH, 23 (7): (1-13). [PMID:36207561] |
11. Bozhi Ye, Xudong Chen, Shanshan Dai, Jibo Han, Xiaohe Liang, Shuang Lin, Xueli Cai, Zhouqing Huang, Weijian Huang. (2022) Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes. Drug Design Development and Therapy, [PMID:30988600] |
12. Tingting Lin, Ben Chen, Liqun Fang, Haibo You, Chu Chu, Qingsong Shao, Shengqiang Tong. (2022) Solvent strength of organic phase for two biphasic solvent systems in high speed countercurrent chromatography. JOURNAL OF CHROMATOGRAPHY A, 1680 (463422). [PMID:36037578] |
13. Dan Xiu, Sibo Zhao, Zhenhua Li, Yanan Xu, Yao Wang, Zhijun Zhu, Min Zhang, Christopher D. Snow, Laurence A. Belfiore, Jianguo Tang. (2022) Conditionally designed luminescent DNA crystals doped by Ln3+(Eu3+/Tb3+) complexes or fluorescent proteins with smart drug sensing property. Journal of Materials Chemistry B, 10 (34): (6443-6452). [PMID:35703105] |
14. Shuang Luo, Jinrong He, Shaowei Huang, Xiaojing Wang, Yulin Su, Yanyang Li, Yanping Chen, Guanghua Yang, Bin Huang, Shaoju Guo, Lian Zhou, Xia Luo. (2022) Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe. PHYTOMEDICINE, 104 (154106). [PMID:35728384] |
15. Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu. (2022) Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis. Frontiers in Pharmacology, 13 (842720). [PMID:35392552] |
16. Ying Xu, Xuan Yu, Jiaqi Gui, Yiqun Wan, Jinping Chen, Ting Tan, Fan Liu, Lan Guo. (2022) Ultrasonic Solvent Extraction Followed by Dispersive Solid Phase Extraction (d-SPE) Cleanup for the Simultaneous Determination of Five Anthraquinones in Polygonum multiflorum by UHPLC-PDA. Foods, 11 (3): (386). [PMID:35159536] |
17. Jinfeng Liu, Liang Ning. (2021) Protective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway. Bioengineered, 12 (2): (10246-10253). [PMID:34839778] |
18. Xiao Yu, Wanxiang Yu, Xiaohui Zhang, Yongjie Wang, Shumei Wang, Haiyun Zhai. (2021) Simultaneous determination of flavonoids and anthraquinones in honey by using SPE-CE-LIF. ANALYTICAL BIOCHEMISTRY, 631 (114373). [PMID:34509444] |
19. Song Zhi-Man, Zhang Jun-Liang, Zhou Kun, Yue Lu-Ming, Zhang Yu, Wang Chang-Yun, Wang Kai-Ling, Xu Ying. (2021) Anthraquinones as Potential Antibiofilm Agents Against Methicillin-Resistant Staphylococcus aureus. Frontiers in Microbiology, 12 [PMID:34539607] |
20. Shanshan Dai, Bozhi Ye, Longwang Chen, Guangliang Hong, Guangju Zhao, Zhongqiu Lu. (2021) Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation. PHYTOTHERAPY RESEARCH, 35 (9): (5203-5213). [PMID:34131970] |
21. Lijie Hou, Chao Kong, Zhongai Hu, Yanxia Han, Bowan Wu. (2021) Redox active organic molecule-Emodin modified graphene for high-performance supercapacitors. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 895 (115402). [PMID:] |
22. Jing Liang, Ke Min, Piao Long, Xuqian Weng, Qun Huang, Bo Chen, Ming Ma. (2021) Selective adsorption of flavonoids on cerium-doped ferroferric oxide magnetic particles. JOURNAL OF CHROMATOGRAPHY A, 1648 (462189). [PMID:33975082] |
23. Liu Hui, Qiu Xiaojun, Li Zhi, Zhu Xiaomei, Sun Bing, Zhang Xiaoxing. (2021) Higher photochemical production of bromophenol by quinone-like substances extracted from humic substances using a new emodin-imprinted polymer. Environmental Chemistry Letters, 19 (4): (3517-3522). [PMID:] |
24. Guodong Zheng, Jiahui Zheng, Le Xiao, Tongyi Shang, Yanjun Cai, Yuwei Li, Yiming Xu, Xiaoming Chen, Yun Liu, Bin Yang. (2021) Construction of a Phenylboronic Acid-Functionalized Nano-Prodrug for pH-Responsive Emodin Delivery and Antibacterial Activity. ACS Omega, 6 (12): (8672–8679). [PMID:33817529] |
25. Lishan Tan, Xiulong Deng, Xuandi Lai, Tao Zeng, Aiqing Li, Jianqiang Hu, Zuying Xiong. (2020) Mesoscale nanoparticles encapsulated with emodin for targeting antifibrosis in animal models. Open Chemistry, 18 (1): (1207-1216). [PMID:] |
26. Yan Zhang, Qing-nan Li, Kaiyue Zhou, Qinfeng Xu, Chun-yang Zhang. (2020) Identification of Specific N6-Methyladenosine RNA Demethylase FTO Inhibitors by Single-Quantum-Dot-Based FRET Nanosensors. ANALYTICAL CHEMISTRY, 92 (20): (13936–13944). [PMID:32972135] |
27. Jing Zhang, Nini Li, Dongmei Zhang, Mengjin Dong, Changhao Wang, Yashao Chen. (2020) Construction of cinnamic acids derived β-cyclodextrins and their emodin-based inclusions with enhanced water solubility, excellent antioxidant and antibacterial activities. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 606 (125382). [PMID:] |
28. Yulian Chen, Tao Zhang, Lili Wu, Yilin Huang, Zhihao Mao, Zhikun Zhan, Weizhong Chen, Fahong Dai, Wenyu Cao, Yong Cao, Shuwen Liu, Zheng Cai, Lan Tang. (2020) Metabolism and Toxicity of Emodin: Genome-Wide Association Studies Reveal Hepatocyte Nuclear Factor 4α Regulates UGT2B7 and Emodin Glucuronidation. CHEMICAL RESEARCH IN TOXICOLOGY, 33 (7): (1798–1808). [PMID:32538071] |
29. Zhao Yanfang, Xie Hanyi, Zhao Mei, Li Huijuan, Chen Xiangfeng, Cai Zongwei, Song Hexing. (2019) Core-shell hollow spheres of type C@MoS2 for use in surface-assisted laser desorption/ionization time of flight mass spectrometry of small molecules. MICROCHIMICA ACTA, 186 (12): (1-9). [PMID:31754806] |
30. Chi Chen, Zhuang Fu, Weiying Zhou, Qiushi Chen, Chenzhao Wang, Lu Xu, Zhibing Wang, Hanqi Zhang. (2020) Ionic liquid-immobilized NaY zeolite-based matrix solid phase dispersion for the extraction of active constituents in Rheum palmatum L.. MICROCHEMICAL JOURNAL, 152 (104245). [PMID:] |
31. Yunchang Fan, Zeyu Niu, Chen Xu, Lei Yang, Tuojie Yang. (2019) Protic Ionic Liquids as Efficient Solvents in Microwave-Assisted Extraction of Rhein and Emodin from Rheum palmatum L.. MOLECULES, 24 (15): (2770). [PMID:31366111] |
32. Cui Hong-Xin, Zhang Ling-Shuai, Luo Yang, Yuan Ke, Huang Zhi-Yong, Guo Ying. (2019) A Purified Anthraquinone-Glycoside Preparation From Rhubarb Ameliorates Type 2 Diabetes Mellitus by Modulating the Gut Microbiota and Reducing Inflammation. Frontiers in Microbiology, 10 (1423). [PMID:31293553] |
33. Kai-Yuan Huang, Hong-Xing He, Shao-Bin He, Xiang-Ping Zhang, Hua-Ping Peng, Zhen Lin, Hao-Hua Deng, Xing-Hua Xia, Wei Chen. (2019) Gold nanocluster-based fluorescence turn-off probe for sensing of doxorubicin by photoinduced electron transfer. SENSORS AND ACTUATORS B-CHEMICAL, 296 (126656). [PMID:] |
34. Qingqing Hao, Lilin Lu, Xianwen Kan. (2019) Probe and analogue: Double roles of thionine for aloe-emodin selective and sensitive ratiometric detection. SENSORS AND ACTUATORS B-CHEMICAL, 292 (247). [PMID:] |
35. Chao Yu, Jian Lu, Qi Zhang, Hougang Fan, Minjia Meng, Shi Zhou, Yinhua Jiang, Yongsheng Yan, Yilin Wu, Chunxiang Li. (2019) Bioinspired Fabrication and Evaluation of Molecularly Imprinted Nanocomposite Membranes with Inorganic/Organic Multilevel Structure for the Selective Separation of Emodin. NANO, [PMID:] |
36. Jian Lu, Yingying Qin, Qi Zhang, Chao Yu, Yilin Wu, Yongsheng Yan, Hougang Fan, Minjia Meng, Chunxiang Li. (2019) Antibacterial, high-flux and 3D porous molecularly imprinted nanocomposite sponge membranes for cross-flow filtration of emodin from analogues. CHEMICAL ENGINEERING JOURNAL, 360 (483). [PMID:] |
37. Ning Li, Ning Wang, Tingni Wu, Changlu Qiu, Xueting Wang, Shaohong Jiang, Zina Zhang, Ting Liu, Chunliu Wei, Ting Wang. (2018) Preparation of curcumin-hydroxypropyl-β-cyclodextrin inclusion complex by cosolvency-lyophilization procedure to enhance oral bioavailability of the drug. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, [PMID:30059244] |
38. Lili Wu, Yulian Chen, Han Liu, Zhikun Zhan, Zhi Liang, Tao Zhang, Zheng Cai, Ling Ye, Menghua Liu, Jie Zhao, Shuwen Liu, Lan Tang. (2018) Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2. TOXICOLOGY AND APPLIED PHARMACOLOGY, 359 (91). [PMID:30248416] |
39. Lili Wu, Weichao Han, Yulian Chen, Tao Zhang, Junjin Liu, Shilong Zhong, Han Liu, Congcong Han, Zhongyi Zhang, Shuwen Liu, Lan Tang. (2018) Gender Differences in the Hepatotoxicity and Toxicokinetics of Emodin: The Potential Mechanisms Mediated by UGT2B7 and MRP2. MOLECULAR PHARMACEUTICS, 15 (9): (3931–3945). [PMID:30011215] |
40. Jing Zhu, Qilong Wang, Huihua Li, Huiyun Zhang, Yuan Zhu, Emmanuel Omari-Siaw, Congyong Sun, Qiuyu Wei, Wenwen Deng, Jiangnan Yu, Ximing Xu. (2018) Galangin-loaded, liver targeting liposomes: Optimization and hepatoprotective efficacy. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 46 (339). [PMID:] |
41. Shuang Luo, Xiangliang Deng, Qi Liu, Zengfeng Pan, Zhongxiang Zhao, Lian Zhou, Xia Luo. (2018) Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice. INTERNATIONAL IMMUNOPHARMACOLOGY, 59 (269). [PMID:29669309] |
42. Hongzhang Cui, Shu Li, Caiming Xu, Jingwen Zhang, Zhongwei Sun, Hailong Chen. (2017) Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis. Molecular Medicine Reports, 16 (4): (5121-5128). [PMID:28849044] |
43. Xiaoya Jiang, Xiaoyan Jiao, Doudou Zhang, Ligai Bai, Haiyan Liu, Hongyuan Yan. (2017) Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatum L.. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (21): [PMID:] |
44. Dong Dong, Tianpeng Zhang, Danyi Lu, Jie Liu, Baojian Wu. (2017) In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes. XENOBIOTICA, 47 (4): (277-283). [PMID:27180825] |
45. Tianpeng Zhang, Dong Dong, Danyi Lu, Shuai Wang, Baojian Wu. (2016) Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 501 (190). [PMID:26850314] |
46. Xingqiang Wu, Shuxuan Liang, Xusheng Ge, Yunkai Lv, Hanwen Sun. (2015) Synthesis and evaluation of dummy molecularly imprinted microspheres for the specific solid-phase extraction of six anthraquinones from slimming tea. JOURNAL OF SEPARATION SCIENCE, 38 (8): (1263-1270). [PMID:25677958] |
47. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] |
48. Dan Li, Shaopu Liu, Yizhong Shen, Jidong Yang, Youqiu He. (2014) Molecular spectroscopic studies on the interactions of rhein and emodin with thioglycolic acid-capped core/shell CdTe/CdS quantum dots and their analytical applications. LUMINESCENCE, 30 (1): (60-66). [PMID:24850622] |
49. Jiarun Tu, Wensheng Cai, Xueguang Shao. (2014) Direct quantitative analysis from the current curve data of pulse voltammetric techniques. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 725 (25). [PMID:] |
50. Jiarun Tu, Wensheng Cai, Xueguang Shao. (2014) Enhancing the sensitivity of potential step voltammetry using chemometric resolution. ANALYST, 139 (5): (1016-1022). [PMID:24409452] |
51. Dan Tang,Jia-Xiao Zhu,An-Guo Wu,You-Hua Xu,Ting-Ting Duan,Zhao-Guang Zheng,Ru-Shang Wang,Dan Li,Quan Zhu. (2013-03-16) Pre-column incubation followed by fast liquid chromatography analysis for rapid screening of natural methylglyoxal scavengers directly from herbal medicines: case study of Polygonum cuspidatum.. Journal of chromatography. A, 1286 (102-110). [PMID:23489496] |
1. Yan Zhou, Yang Hu, Bin Zhu, Lei Liu, Jiong Chen. (2024) Emodin modulates the host antiviral response of fish against spring viremia of carp virus infection. AQUACULTURE, 580 (740347). [PMID:3011602] |
2. Shanshan Dai, Yunxuan Chen, Xiaoxi Fan, Jibo Han, Lingfeng Zhong, Yucong Zhang, Qingran Liu, Jiahui Lin, Weijian Huang, Lan Su, Zhouqing Huang, Bozhi Ye. (2023) Emodin attenuates cardiomyocyte pyroptosis in doxorubicin-induced cardiotoxicity by directly binding to GSDMD. PHYTOMEDICINE, (24): (155105). [PMID:37801893] |
3. Cao Xia, Deng Tianwen, Zhu Qin, Wang Jianping, Shi Wenwan, Liu Qi, Yu Qintong, Deng Wenwen, Yu Jiangnan, Wang Qilong, Xiao Gao, Xu Ximing. (2023) Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy. AAPS PHARMSCITECH, 24 (6): (1-17). [PMID:37380936] |
4. Rongkun Zhu, Zengcheng Du, Mingfang Zhu, Huanru Liang, Shumei Wang, Qing Zhou, Rui Li, Yulan Li, Chaoying Zeng, Wenhao Liu, Qiqing Chen. (2023) Molecularly imprinted polymers embedded with double perovskite quantum dots: A ratiometric fluorescence sensor for visible and fluorescent determination of Rhein. CHEMICAL ENGINEERING JOURNAL, 468 (143618). [PMID:] |
5. Peiyuan Li, Fangzhou Wen, Hongjun Yan, Qiuting Xu, Wei Su. (2023) Antimicrobial activity of Emodin in combination with visible light against Escherichia coli and Staphylococcus aureus: Applications for food safety technology. LWT-FOOD SCIENCE AND TECHNOLOGY, 181 (114750). [PMID:] |
6. Senlin Hou, Quancheng Liu, Hu Deng, Jun He, Wei Zhao, Zhixiang Wu, Qi Zhang, Liping Shang. (2023) Identification and low-frequency vibrational analysis of three free anthraquinones via terahertz spectroscopy. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 293 (122439). [PMID:36773425] |
7. Zhao Jieyun, Su Xiaowei, Jiang Lina, Ren Yuanlin, Liu Xiaohui, Cheng Chunzu. (2023) A sustainable approach to enhance flame retardant, antibacterial and UV resistance of lyocell fabrics treated with luffa phosphate derivatives and emodin. CELLULOSE, 30 (2): (1265-1285). [PMID:] |
8. Zhenming Gao, Jidong Sui, Rong Fan, Weikun Qu, Xuepeng Dong, Deguang Sun. (2022) Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling. Drug Design Development and Therapy, [PMID:32546964] |
9. Chujun Chen, Zhenming Lin, Wenbin Liu, Qiong Hu, Jie Wang, Xiaoyan Zhuang, Sujuan Guan, Xiaoting Wu, Tingting Hu, Shijian Quan, Xiaobao Jin, Juan Shen. (2022) Emodin accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization. EUROPEAN JOURNAL OF PHARMACOLOGY, 936 (175329). [PMID:36341884] |
10. Cao Xia, He Qing, Adu-Frimpong Michael, Shen Xinyi, Rong Wanjing, Li Xiaoxiao, Zhang Jian, Xia Xiaoli, Shi Feng, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing. (2022) Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity. AAPS PHARMSCITECH, 23 (7): (1-13). [PMID:36207561] |
11. Bozhi Ye, Xudong Chen, Shanshan Dai, Jibo Han, Xiaohe Liang, Shuang Lin, Xueli Cai, Zhouqing Huang, Weijian Huang. (2022) Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes. Drug Design Development and Therapy, [PMID:30988600] |
12. Tingting Lin, Ben Chen, Liqun Fang, Haibo You, Chu Chu, Qingsong Shao, Shengqiang Tong. (2022) Solvent strength of organic phase for two biphasic solvent systems in high speed countercurrent chromatography. JOURNAL OF CHROMATOGRAPHY A, 1680 (463422). [PMID:36037578] |
13. Dan Xiu, Sibo Zhao, Zhenhua Li, Yanan Xu, Yao Wang, Zhijun Zhu, Min Zhang, Christopher D. Snow, Laurence A. Belfiore, Jianguo Tang. (2022) Conditionally designed luminescent DNA crystals doped by Ln3+(Eu3+/Tb3+) complexes or fluorescent proteins with smart drug sensing property. Journal of Materials Chemistry B, 10 (34): (6443-6452). [PMID:35703105] |
14. Shuang Luo, Jinrong He, Shaowei Huang, Xiaojing Wang, Yulin Su, Yanyang Li, Yanping Chen, Guanghua Yang, Bin Huang, Shaoju Guo, Lian Zhou, Xia Luo. (2022) Emodin targeting the colonic metabolism via PPARγ alleviates UC by inhibiting facultative anaerobe. PHYTOMEDICINE, 104 (154106). [PMID:35728384] |
15. Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu. (2022) Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis. Frontiers in Pharmacology, 13 (842720). [PMID:35392552] |
16. Ying Xu, Xuan Yu, Jiaqi Gui, Yiqun Wan, Jinping Chen, Ting Tan, Fan Liu, Lan Guo. (2022) Ultrasonic Solvent Extraction Followed by Dispersive Solid Phase Extraction (d-SPE) Cleanup for the Simultaneous Determination of Five Anthraquinones in Polygonum multiflorum by UHPLC-PDA. Foods, 11 (3): (386). [PMID:35159536] |
17. Jinfeng Liu, Liang Ning. (2021) Protective role of emodin in rats with post-myocardial infarction heart failure and influence on extracellular signal-regulated kinase pathway. Bioengineered, 12 (2): (10246-10253). [PMID:34839778] |
18. Xiao Yu, Wanxiang Yu, Xiaohui Zhang, Yongjie Wang, Shumei Wang, Haiyun Zhai. (2021) Simultaneous determination of flavonoids and anthraquinones in honey by using SPE-CE-LIF. ANALYTICAL BIOCHEMISTRY, 631 (114373). [PMID:34509444] |
19. Song Zhi-Man, Zhang Jun-Liang, Zhou Kun, Yue Lu-Ming, Zhang Yu, Wang Chang-Yun, Wang Kai-Ling, Xu Ying. (2021) Anthraquinones as Potential Antibiofilm Agents Against Methicillin-Resistant Staphylococcus aureus. Frontiers in Microbiology, 12 [PMID:34539607] |
20. Shanshan Dai, Bozhi Ye, Longwang Chen, Guangliang Hong, Guangju Zhao, Zhongqiu Lu. (2021) Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation. PHYTOTHERAPY RESEARCH, 35 (9): (5203-5213). [PMID:34131970] |
21. Lijie Hou, Chao Kong, Zhongai Hu, Yanxia Han, Bowan Wu. (2021) Redox active organic molecule-Emodin modified graphene for high-performance supercapacitors. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 895 (115402). [PMID:] |
22. Jing Liang, Ke Min, Piao Long, Xuqian Weng, Qun Huang, Bo Chen, Ming Ma. (2021) Selective adsorption of flavonoids on cerium-doped ferroferric oxide magnetic particles. JOURNAL OF CHROMATOGRAPHY A, 1648 (462189). [PMID:33975082] |
23. Liu Hui, Qiu Xiaojun, Li Zhi, Zhu Xiaomei, Sun Bing, Zhang Xiaoxing. (2021) Higher photochemical production of bromophenol by quinone-like substances extracted from humic substances using a new emodin-imprinted polymer. Environmental Chemistry Letters, 19 (4): (3517-3522). [PMID:] |
24. Guodong Zheng, Jiahui Zheng, Le Xiao, Tongyi Shang, Yanjun Cai, Yuwei Li, Yiming Xu, Xiaoming Chen, Yun Liu, Bin Yang. (2021) Construction of a Phenylboronic Acid-Functionalized Nano-Prodrug for pH-Responsive Emodin Delivery and Antibacterial Activity. ACS Omega, 6 (12): (8672–8679). [PMID:33817529] |
25. Lishan Tan, Xiulong Deng, Xuandi Lai, Tao Zeng, Aiqing Li, Jianqiang Hu, Zuying Xiong. (2020) Mesoscale nanoparticles encapsulated with emodin for targeting antifibrosis in animal models. Open Chemistry, 18 (1): (1207-1216). [PMID:] |
26. Yan Zhang, Qing-nan Li, Kaiyue Zhou, Qinfeng Xu, Chun-yang Zhang. (2020) Identification of Specific N6-Methyladenosine RNA Demethylase FTO Inhibitors by Single-Quantum-Dot-Based FRET Nanosensors. ANALYTICAL CHEMISTRY, 92 (20): (13936–13944). [PMID:32972135] |
27. Jing Zhang, Nini Li, Dongmei Zhang, Mengjin Dong, Changhao Wang, Yashao Chen. (2020) Construction of cinnamic acids derived β-cyclodextrins and their emodin-based inclusions with enhanced water solubility, excellent antioxidant and antibacterial activities. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 606 (125382). [PMID:] |
28. Yulian Chen, Tao Zhang, Lili Wu, Yilin Huang, Zhihao Mao, Zhikun Zhan, Weizhong Chen, Fahong Dai, Wenyu Cao, Yong Cao, Shuwen Liu, Zheng Cai, Lan Tang. (2020) Metabolism and Toxicity of Emodin: Genome-Wide Association Studies Reveal Hepatocyte Nuclear Factor 4α Regulates UGT2B7 and Emodin Glucuronidation. CHEMICAL RESEARCH IN TOXICOLOGY, 33 (7): (1798–1808). [PMID:32538071] |
29. Zhao Yanfang, Xie Hanyi, Zhao Mei, Li Huijuan, Chen Xiangfeng, Cai Zongwei, Song Hexing. (2019) Core-shell hollow spheres of type C@MoS2 for use in surface-assisted laser desorption/ionization time of flight mass spectrometry of small molecules. MICROCHIMICA ACTA, 186 (12): (1-9). [PMID:31754806] |
30. Chi Chen, Zhuang Fu, Weiying Zhou, Qiushi Chen, Chenzhao Wang, Lu Xu, Zhibing Wang, Hanqi Zhang. (2020) Ionic liquid-immobilized NaY zeolite-based matrix solid phase dispersion for the extraction of active constituents in Rheum palmatum L.. MICROCHEMICAL JOURNAL, 152 (104245). [PMID:] |
31. Yunchang Fan, Zeyu Niu, Chen Xu, Lei Yang, Tuojie Yang. (2019) Protic Ionic Liquids as Efficient Solvents in Microwave-Assisted Extraction of Rhein and Emodin from Rheum palmatum L.. MOLECULES, 24 (15): (2770). [PMID:31366111] |
32. Cui Hong-Xin, Zhang Ling-Shuai, Luo Yang, Yuan Ke, Huang Zhi-Yong, Guo Ying. (2019) A Purified Anthraquinone-Glycoside Preparation From Rhubarb Ameliorates Type 2 Diabetes Mellitus by Modulating the Gut Microbiota and Reducing Inflammation. Frontiers in Microbiology, 10 (1423). [PMID:31293553] |
33. Kai-Yuan Huang, Hong-Xing He, Shao-Bin He, Xiang-Ping Zhang, Hua-Ping Peng, Zhen Lin, Hao-Hua Deng, Xing-Hua Xia, Wei Chen. (2019) Gold nanocluster-based fluorescence turn-off probe for sensing of doxorubicin by photoinduced electron transfer. SENSORS AND ACTUATORS B-CHEMICAL, 296 (126656). [PMID:] |
34. Qingqing Hao, Lilin Lu, Xianwen Kan. (2019) Probe and analogue: Double roles of thionine for aloe-emodin selective and sensitive ratiometric detection. SENSORS AND ACTUATORS B-CHEMICAL, 292 (247). [PMID:] |
35. Chao Yu, Jian Lu, Qi Zhang, Hougang Fan, Minjia Meng, Shi Zhou, Yinhua Jiang, Yongsheng Yan, Yilin Wu, Chunxiang Li. (2019) Bioinspired Fabrication and Evaluation of Molecularly Imprinted Nanocomposite Membranes with Inorganic/Organic Multilevel Structure for the Selective Separation of Emodin. NANO, [PMID:] |
36. Jian Lu, Yingying Qin, Qi Zhang, Chao Yu, Yilin Wu, Yongsheng Yan, Hougang Fan, Minjia Meng, Chunxiang Li. (2019) Antibacterial, high-flux and 3D porous molecularly imprinted nanocomposite sponge membranes for cross-flow filtration of emodin from analogues. CHEMICAL ENGINEERING JOURNAL, 360 (483). [PMID:] |
37. Ning Li, Ning Wang, Tingni Wu, Changlu Qiu, Xueting Wang, Shaohong Jiang, Zina Zhang, Ting Liu, Chunliu Wei, Ting Wang. (2018) Preparation of curcumin-hydroxypropyl-β-cyclodextrin inclusion complex by cosolvency-lyophilization procedure to enhance oral bioavailability of the drug. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, [PMID:30059244] |
38. Lili Wu, Yulian Chen, Han Liu, Zhikun Zhan, Zhi Liang, Tao Zhang, Zheng Cai, Ling Ye, Menghua Liu, Jie Zhao, Shuwen Liu, Lan Tang. (2018) Emodin-induced hepatotoxicity was exacerbated by probenecid through inhibiting UGTs and MRP2. TOXICOLOGY AND APPLIED PHARMACOLOGY, 359 (91). [PMID:30248416] |
39. Lili Wu, Weichao Han, Yulian Chen, Tao Zhang, Junjin Liu, Shilong Zhong, Han Liu, Congcong Han, Zhongyi Zhang, Shuwen Liu, Lan Tang. (2018) Gender Differences in the Hepatotoxicity and Toxicokinetics of Emodin: The Potential Mechanisms Mediated by UGT2B7 and MRP2. MOLECULAR PHARMACEUTICS, 15 (9): (3931–3945). [PMID:30011215] |
40. Jing Zhu, Qilong Wang, Huihua Li, Huiyun Zhang, Yuan Zhu, Emmanuel Omari-Siaw, Congyong Sun, Qiuyu Wei, Wenwen Deng, Jiangnan Yu, Ximing Xu. (2018) Galangin-loaded, liver targeting liposomes: Optimization and hepatoprotective efficacy. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 46 (339). [PMID:] |
41. Shuang Luo, Xiangliang Deng, Qi Liu, Zengfeng Pan, Zhongxiang Zhao, Lian Zhou, Xia Luo. (2018) Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice. INTERNATIONAL IMMUNOPHARMACOLOGY, 59 (269). [PMID:29669309] |
42. Hongzhang Cui, Shu Li, Caiming Xu, Jingwen Zhang, Zhongwei Sun, Hailong Chen. (2017) Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis. Molecular Medicine Reports, 16 (4): (5121-5128). [PMID:28849044] |
43. Xiaoya Jiang, Xiaoyan Jiao, Doudou Zhang, Ligai Bai, Haiyan Liu, Hongyuan Yan. (2017) Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatum L.. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (21): [PMID:] |
44. Dong Dong, Tianpeng Zhang, Danyi Lu, Jie Liu, Baojian Wu. (2017) In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes. XENOBIOTICA, 47 (4): (277-283). [PMID:27180825] |
45. Tianpeng Zhang, Dong Dong, Danyi Lu, Shuai Wang, Baojian Wu. (2016) Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 501 (190). [PMID:26850314] |
46. Xingqiang Wu, Shuxuan Liang, Xusheng Ge, Yunkai Lv, Hanwen Sun. (2015) Synthesis and evaluation of dummy molecularly imprinted microspheres for the specific solid-phase extraction of six anthraquinones from slimming tea. JOURNAL OF SEPARATION SCIENCE, 38 (8): (1263-1270). [PMID:25677958] |
47. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] |
48. Dan Li, Shaopu Liu, Yizhong Shen, Jidong Yang, Youqiu He. (2014) Molecular spectroscopic studies on the interactions of rhein and emodin with thioglycolic acid-capped core/shell CdTe/CdS quantum dots and their analytical applications. LUMINESCENCE, 30 (1): (60-66). [PMID:24850622] |
49. Jiarun Tu, Wensheng Cai, Xueguang Shao. (2014) Direct quantitative analysis from the current curve data of pulse voltammetric techniques. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 725 (25). [PMID:] |
50. Jiarun Tu, Wensheng Cai, Xueguang Shao. (2014) Enhancing the sensitivity of potential step voltammetry using chemometric resolution. ANALYST, 139 (5): (1016-1022). [PMID:24409452] |
51. Dan Tang,Jia-Xiao Zhu,An-Guo Wu,You-Hua Xu,Ting-Ting Duan,Zhao-Guang Zheng,Ru-Shang Wang,Dan Li,Quan Zhu. (2013-03-16) Pre-column incubation followed by fast liquid chromatography analysis for rapid screening of natural methylglyoxal scavengers directly from herbal medicines: case study of Polygonum cuspidatum.. Journal of chromatography. A, 1286 (102-110). [PMID:23489496] |