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Enalaprilat - ≥99%, high purity , CAS No.76420-72-9, Inhibitor of Angiotensin-converting enzyme
Basic Description Synonyms Enalaprilat|76420-72-9|Enalapril acid|Enalaprilate|Enalaprilatum|Enalaprilic acid|Enalaprilat anhydrous|Enalapril diacid|ENALAPRILAT DIHYDRATE|enalaprilat (anhydrous)|(S)-1-((S)-2-(((S)-1-Carboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic aci Specifications & Purity Moligand™, ≥99% Shipped In Normal Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of Angiotensin-converting enzyme Product Description Enalaprilat is the active form of Enalapril. Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril. Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.
Names and Identifiers IUPAC Name (2S)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic acid INCHI InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1 InChi Key LZFZMUMEGBBDTC-QEJZJMRPSA-N Canonical SMILES CC(C(=O)N1CCCC1C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O Isomeric SMILES C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)N[C@@H](CCC2=CC=CC=C2)C(=O)O Alternate CAS 76420-72-9,84680-54-6,84680-54-6 (Parent) PubChem CID 5462501 NSC Number 760053 MeSH Entry Terms 1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate;Enalaprilat;Enalaprilat Anhydrous;Enalaprilat Citrate, Anhydrous;Enalaprilat Dihydrate;Enalaprilat, (R)-Isomer, Anhydrous;Enalaprilic Acid;MK 422;MK-422;MK422;Pres iv;Vasotec;Xanef Molecular Weight 384.42
Chemical and Physical Properties Solubility Slightly soluble in water.
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
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I1524076