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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E174257-5mg | 5mg | In stock | $48.90 | |
E174257-10mg | 10mg | In stock | $78.90 | |
E174257-25mg | 25mg | In stock | $108.90 | |
E174257-50mg | 50mg | In stock | $137.90 | |
E174257-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $177.90 |
Synonyms | 1802003-09-3 | Enasidenib [USAN:INN] | IDHIFA | SCHEMBL15102202 | 2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol | DYLUUSLLRIQKOE-UHFFFAOYSA-N | ENASIDENIB [MI] | EX-A654 | |
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Specifications & Purity | Moligand™, ≥97% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of isocitrate dehydrogenase (NADP(+)) 2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-methyl-1-[[4-[6-(trifluoromethyl)pyridin-2-yl]-6-[[2-(trifluoromethyl)pyridin-4-yl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol |
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INCHI | InChI=1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32) |
InChi Key | DYLUUSLLRIQKOE-UHFFFAOYSA-N |
Canonical SMILES | CC(C)(CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F)O |
Isomeric SMILES | CC(C)(CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F)O |
PubChem CID | 89683805 |
Molecular Weight | 473.4 |
CAS Registry No. | 1446502-11-9 |
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PubChem CID | 89683805 |
RCSB PDB Ligand | 69Q |
DrugCentral Ligand | 5251 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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B2216249 | Certificate of Analysis | Nov 18, 2024 | E174257 |
B2216250 | Certificate of Analysis | Nov 18, 2024 | E174257 |
B2216399 | Certificate of Analysis | Nov 18, 2024 | E174257 |
B2216400 | Certificate of Analysis | Nov 18, 2024 | E174257 |
B2216465 | Certificate of Analysis | Nov 18, 2024 | E174257 |
Solubility | ≥47.3 mg/mL in DMSO; insoluble in H2O; ≥22.9 mg/mL in EtOH |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
1. Kim ES. (2017) Enasidenib: First Global Approval.. Drugs, 77 (15): (1705-1711). [PMID:28879540] [10.1021/op500134e] |