Endo 5-Hexyl-4-phenyl-3a-(1-phenylvinyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl sulfamide , CAS No.E609386, Agonist of Liver receptor homolog-1

Item Number

E609386

Grouped product items
SKU	Size	Availability	Price	Qty
E609386-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
E609386-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of Liver receptor homolog-1

Associated Targets(Human)

NR5A2 Tchem Nuclear receptor subfamily 5 group A member 2 (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR5A2 Tchem Orphan nuclear receptor LRH-1 (736 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	Endo 5-Hexyl-4-phenyl-3a-(1-phenylvinyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl sulfamide
INCHI	InChI=1S/C28H36N2O2S/c1-3-4-5-8-17-24-20-25-26(30-33(29,31)32)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,30H,2-5,8,17-20H2,1H3,(H2,29,31,32)/t25?,26-,28-/m0/s1
InChi Key	COQCBADNBTZWQG-KKGVWULHSA-N
Canonical SMILES	CCCCCCC1=C(c2ccccc2)[C@]2(C(C1)[C@H](CC2)NS(=O)(=O)N)C(=C)c1ccccc1
Isomeric SMILES	CCCCCCC1=C([C@@]2(CC[C@@H](C2C1)NS(=O)(=O)N)C(=C)C3=CC=CC=C3)C4=CC=CC=C4
PubChem CID	139030532

References

1. Mays SG, Flynn AR, Cornelison JL, Okafor CD, Wang H, Wang G, Huang X, Donaldson HN, Millings EJ, Polavarapu R et al.. (2019) Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.. J Med Chem, 62 (24): (11022-11034). [PMID:31419141] [10.1021/op500134e]

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Basic Description