Potent endogenous μ opioid receptor agonist (K i values are 0.69, 9.23 and 5.24 nM for opioid receptor subtypes μ, δ and κ, respectively). Antinociceptive activity. Limited ability to cross the blood-brain barrier.
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of μ receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Rónai AZ, Király K, Szebeni A, Szemenyei E, Prohászka Z, Darula Z, Tóth G, Till I, Szalay B, Kató E et al.. (2009) Immunoreactive endomorphin 2 is generated extracellularly in rat isolated L4,5 dorsal root ganglia by DPP-IV.. Regul Pept, 157 (1-3):(1-2). [PMID:19540879][10.1021/op500134e]
2.Zadina JE, Hackler L, Ge LJ, Kastin AJ. (1997) A potent and selective endogenous agonist for the mu-opiate receptor.. Nature, 386 (6624):(499-502). [PMID:9087409][10.1021/op500134e]
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