endothelin-1, CAS No.123626-67-5, Agonist of ET A receptor

Features and benefits
    Item Number
    rp173960
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp173960-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp173960-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90
    View related series
    ETA receptor Agonist

    Basic Description

    Product Nameendothelin-1, CAS No.123626-67-5
    SynonymsEndothelin 1, >=97.0% (HPLC) | Endothelin 1??, Vetec(TM) reagent grade, >=97% | L-cysteinyl-L-seryl-L-cysteinyl-L-seryl-L-seryl-L-leucyl-L-methionyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-cysteinyl-L-histi
    GradeMoligand™
    Specifications & PurityMoligand™
    Action TypeAGONIST
    Mechanism of actionAgonist of ET A receptor

    Associated Targets(Human)

    EDN1 Tbio Endothelin-1 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    EDNRA Tclin Endothelin-1 receptor (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Mechanisms of Action

    Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

    Product Specifications

    CAS123626-67-5

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate NamesEndothelin 1, >=97.0% (HPLC) | Endothelin 1??, Vetec(TM) reagent grade, >=97% | L-cysteinyl-L-seryl-L-cysteinyl-L-seryl-L-seryl-L-leucyl-L-methionyl-L-alpha-aspartyl-L-lysyl-L-alpha-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-cysteinyl-L-histi
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    Citations of This Product

    1. Lv Jinpeng, Jiang Songzhou, Yang Ying, Zhang Ximei, Gao Rongyin, Cao Yan, Song Guoqiang.  (2020)  FGIN-1-27 Inhibits Melanogenesis by Regulating Protein Kinase A/cAMP-Responsive Element-Binding, Protein Kinase C-β, and Mitogen-Activated Protein Kinase Pathways.  Frontiers in Pharmacology,  11    [PMID:33390991] [10.3389/fphar.2020.602889]

    References

    1. Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ.  (2016)  Endothelin..  Pharmacol Rev,  68  (2): (357-418).  [PMID:26956245] [10.1021/op500134e]
    2. Abraham GR, Kuc RE, Althage M, Greasley PJ, Ambery P, Maguire JJ, Wilkinson IB, Hoole SP, Cheriyan J, Davenport AP.  (2022)  Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19..  J Mol Cell Cardiol,  71  (13): (1755-70).  [PMID:35339512] [10.1016/j.yjmcc.2022.03.007]
    3. Davenport AP, Kuc RE, Southan C, Maguire JJ.  (2018)  New drugs and emerging therapeutic targets in the endothelin signaling pathway and prospects for personalized precision medicine..  Physiol Res,  67  (Supplementum 1): (S37-S54).  [PMID:29947527] [10.1021/op500134e]
    4. Lv Jinpeng, Jiang Songzhou, Yang Ying, Zhang Ximei, Gao Rongyin, Cao Yan, Song Guoqiang.  (2020)  FGIN-1-27 Inhibits Melanogenesis by Regulating Protein Kinase A/cAMP-Responsive Element-Binding, Protein Kinase C-β, and Mitogen-Activated Protein Kinase Pathways.  Frontiers in Pharmacology,  11    [PMID:33390991] [10.3389/fphar.2020.602889]

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