Enibarcimab (anti-Adrenomedullin) - Primary antibody, specific to ADM, >95%, high purity, Human IgG1, STABILISER of ADM stabiliser

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Features and benefits
  • Host species: Human
  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
Item Number
Ab177847
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab177847-100μg
100μg
In stock
$109.90
Ab177847-1mg
1mg
In stock
$519.90
Ab177847-5mg
5mg
In stock
$1,399.90
Ab177847-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NameEnibarcimab (anti-Adrenomedullin) - Primary antibody, specific to ADM, >95%, high purity, Human IgG1
Specifications & PurityExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Host speciesHuman
SpecificityADM
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeSTABILISER
Mechanism of actionSTABILISER of ADM stabiliser
Product Description

Enibarcimab (anti-Adrenomedullin) is a humanised murine monoclonal immunoglobulin G1 (IgG1) antibody, could be used for acute heart failure, COVID-19 infections and septic shock research.

Product Properties

IsotypeHuman IgG1
Light Chain Typekappa
SDS-PAGE26.3 kDa (Light Chain) & 53.6 kDa (Heavy Chain), under reducing conditions; 196.6 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS2305638-98-4

Images

Enibarcimab (anti-Adrenomedullin) (Ab177847) - SEC
The purity of Enibarcimab (anti-Adrenomedullin) (Ab177847) is more than 95% verified by HPLC.

Associated Targets(Human)

ADM Tbio ADM (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0303117Certificate of AnalysisMar 12, 2024 Ab177847
ZJ24F0303116Certificate of AnalysisMar 12, 2024 Ab177847
ZJ24F0303115Certificate of AnalysisMar 12, 2024 Ab177847

Related Documents

References

1. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T.  (1993)  Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma..  Biochem Biophys Res Commun,  192  (2): (553-60).  [PMID:8387282] [10.1021/op500134e]
2. Kitamura, K K and 5 more authors..  (1993)  Cloning and characterization of cDNA encoding a precursor for human adrenomedullin..  Biochemical and biophysical research communications,    (30):   [PMID:7688224]
3. Ishimitsu, T T and 7 more authors..  (1994)  Genomic structure of human adrenomedullin gene..  Biochemical and biophysical research communications,    (30):   [PMID:8074714]
4. and Samson, W K WK..  (1998)  Proadrenomedullin-derived peptides..  Frontiers in neuroendocrinology,      [PMID:9578982]
5. Champion, H C HC, Nussdorfer, G G GG and Kadowitz, P J PJ..  (1999)  Structure-activity relationships of adrenomedullin in the circulation and adrenal gland..  Regulatory peptides,    (30):   [PMID:10588445]
6. Lucyk, S S, Taha, H H, Yamamoto, H H, Miskolzie, M M and Kotovych, G G..  (2006)  NMR conformational analysis of proadrenomedullin N-terminal 20 peptide, a proangiogenic factor involved in tumor growth..  Biopolymers,      [PMID:16315141]

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