Basic Description

Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson\'s disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the researc
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information Entacapone Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for In vitro Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells. In vivo Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥99%

Associated Targets(Human)

COMT Tclin Catechol O-methyltransferase (5 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Canonical SMILES	CCN(CC)C(=O)\C(=C\C1=CC(=C(O)C(=C1)O)[N+]([O-])=O)C#N
Molecular Weight	305.29

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1. Liangliang Zhu, Hui Lv, Ling Xiao, Yanyao Hou, Wenjuan Li, Guangbo Ge, Chunzhi Ai. (2023) Diverse effects of α-/β-estradiol on catalytic activities of human UDP-glucuronosyltransferases (UGT). JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 225 (106196). [PMID:36181991] [10.1016/j.jsbmb.2022.106196]
2. X. Cui, Y. Zhou, Y. Zheng, L. Cao, L. Gao, J. Duan, H. Yin, S. Ai. (2022) Investigation of the enhanced photoactivity of CdS/Bi2MoO6/MoSe2 and its application in antibody-free enzyme-assisted photoelectrochemical strategy for detection of N6-methyladenosine and FTO protein. Materials Today Nano, 20 (100269). [PMID:] [10.1016/j.mtnano.2022.100269]
3. Ling Xiao, Dehui Chi, Guiju Sheng, Wenjuan Li, Penghui Lin, Sicheng Liang, Liangliang Zhu, Peipei Dong. (2020) Inhibitory effects of UDP-glucuronosyltransferase (UGT) typical ligands against E. coli beta-glucuronidase (GUS). RSC Advances, 10 (39): (22966-22971). [PMID:35520305] [10.1039/D0RA02311F]
4. Xia Lv, Xin-Xin Wang, Jie Hou, Zhong-Ze Fang, Jing-Jing Wu, Yun-Feng Cao, Shu-Wen Liu, Guang-Bo Ge, Ling Yang. (2016) Comparison of the inhibitory effects of tolcapone and entacapone against human UDP-glucuronosyltransferases. TOXICOLOGY AND APPLIED PHARMACOLOGY, 301 (42). [PMID:27089846] [10.1016/j.taap.2016.04.009]

1. Liangliang Zhu, Hui Lv, Ling Xiao, Yanyao Hou, Wenjuan Li, Guangbo Ge, Chunzhi Ai. (2023) Diverse effects of α-/β-estradiol on catalytic activities of human UDP-glucuronosyltransferases (UGT). JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 225 (106196). [PMID:36181991] [10.1016/j.jsbmb.2022.106196]
2. X. Cui, Y. Zhou, Y. Zheng, L. Cao, L. Gao, J. Duan, H. Yin, S. Ai. (2022) Investigation of the enhanced photoactivity of CdS/Bi2MoO6/MoSe2 and its application in antibody-free enzyme-assisted photoelectrochemical strategy for detection of N6-methyladenosine and FTO protein. Materials Today Nano, 20 (100269). [PMID:] [10.1016/j.mtnano.2022.100269]
3. Ling Xiao, Dehui Chi, Guiju Sheng, Wenjuan Li, Penghui Lin, Sicheng Liang, Liangliang Zhu, Peipei Dong. (2020) Inhibitory effects of UDP-glucuronosyltransferase (UGT) typical ligands against E. coli beta-glucuronidase (GUS). RSC Advances, 10 (39): (22966-22971). [PMID:35520305] [10.1039/D0RA02311F]
4. Xia Lv, Xin-Xin Wang, Jie Hou, Zhong-Ze Fang, Jing-Jing Wu, Yun-Feng Cao, Shu-Wen Liu, Guang-Bo Ge, Ling Yang. (2016) Comparison of the inhibitory effects of tolcapone and entacapone against human UDP-glucuronosyltransferases. TOXICOLOGY AND APPLIED PHARMACOLOGY, 301 (42). [PMID:27089846] [10.1016/j.taap.2016.04.009]

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