Entinostat (MS-275) - ≥98%, high purity , Histone deacetylase inhibitor, CAS No.209783-80-2, Histone deacetylase inhibitor

Item Number

E125068

• Synonyms: SNDX-275 | SB16665 | D09338 | MLS006010183 | AC-8968 | CS-0511 | MS-275, A HDAC1 and HDAC3 inhibitor | NSC756642 | NSC-756642 | DB11841 | Carbamic acid, 3-pyridinylmethyl ester | MS-275,Entinostat, SNDX-275, MS-27-275 | W-201831 | N-[[4-[[(2-Aminophenyl)a
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: MS-275 is an inhibitor of HDAC (histone deacetylase) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM). However, MS-275 does not inhibit HDAC8 (IC50 > 100 μM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1),
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Histone deacetylase inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10
An HDAC inhibitor shown to inhibit angiogenesis and metastasis.