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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E127109-25mg | 25mg | In stock | $56.90 | |
E127109-100mg | 100mg | In stock | $187.90 | |
E127109-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $418.90 | |
E127109-250mg | 250mg | In stock | $423.90 | |
E127109-1g | 1g | In stock | $533.90 | |
E127109-5g | 5g | In stock | $1,711.90 |
Synonyms | MDV3100 | AMY10296 | Xtandi (TN) | FT-0673286 | MDV-3100;Enzalutamide;MDV 3100 | Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl- | MFCD14155804 | AB01565849_02 | FT-0670957 | HY-70002 | |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | MDV3100 is an androgen receptor inhibitor and antagonizes induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2) in combination with the synthetic androgen R1881 in parental LNCaP cells. MDV3100 prevents nuclear translo |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Androgen Receptor antagonist |
Product Description | Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM. |
ALogP | 3.6 |
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IUPAC Name | 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N-methylbenzamide |
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INCHI | InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30) |
InChi Key | WXCXUHSOUPDCQV-UHFFFAOYSA-N |
Canonical SMILES | CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C |
Isomeric SMILES | CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C |
Alternate CAS | 915087-33-1 |
PubChem CID | 15951529 |
MeSH Entry Terms | 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-(methyl-d3)benzamide;4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-benzamide;enzalutamide;enzaluta |
Molecular Weight | 464.44 |
DrugBank Ligand | DB08899 |
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PubChem CID | 15951529 |
CAS Registry No. | 915087-33-1 |
ChEMBL Ligand | CHEMBL1082407 |
Wikipedia | Enzalutamide |
PEP | enzalutamide |
DrugCentral Ligand | 4628 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2406169 | Certificate of Analysis | Nov 12, 2024 | E127109 |
A2306489 | Certificate of Analysis | Oct 24, 2024 | E127109 |
A2306513 | Certificate of Analysis | Oct 24, 2024 | E127109 |
A2306517 | Certificate of Analysis | Oct 24, 2024 | E127109 |
A2306527 | Certificate of Analysis | Oct 24, 2024 | E127109 |
A2306477 | Certificate of Analysis | Oct 24, 2024 | E127109 |
A2306528 | Certificate of Analysis | Oct 17, 2024 | E127109 |
A2306523 | Certificate of Analysis | Oct 17, 2024 | E127109 |
A2306510 | Certificate of Analysis | Oct 17, 2024 | E127109 |
A2306505 | Certificate of Analysis | Oct 17, 2024 | E127109 |
I2228198 | Certificate of Analysis | Jul 05, 2024 | E127109 |
F2224029 | Certificate of Analysis | Apr 03, 2024 | E127109 |
F2224030 | Certificate of Analysis | Apr 03, 2024 | E127109 |
B2215238 | Certificate of Analysis | Dec 12, 2023 | E127109 |
B2215264 | Certificate of Analysis | Dec 12, 2023 | E127109 |
L2114014 | Certificate of Analysis | Sep 21, 2023 | E127109 |
L1904046 | Certificate of Analysis | Jul 06, 2023 | E127109 |
C2111198 | Certificate of Analysis | Dec 15, 2022 | E127109 |
B2215246 | Certificate of Analysis | Dec 27, 2021 | E127109 |
B2215241 | Certificate of Analysis | Dec 27, 2021 | E127109 |
Solubility | DMSO ≥90mg/mL Water <1.2mg/mL Ethanol ≥15mg/mL |
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Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child H360D:May damage the unborn child |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
Starting at $266.90
1. Jiang, Zhihui Z, Zhou, Bo B, Li, Xinping X, Kirby, Gordon M GM and Zhang, Xiaoying X.. (2018) Echinacoside Increases Sperm Quantity in Rats by Targeting the Hypothalamic Androgen Receptor.. Scientific reports, (1): [PMID:29497114] |
1. Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS, Iversen P, Bhattacharya S, Carles J, Chowdhury S et al.. (2014) Enzalutamide in metastatic prostate cancer before chemotherapy.. N Engl J Med, 371 (5): (424-33). [PMID:24881730] [10.1021/op500134e] |
2. Hussain M, Fizazi K, Saad F, Rathenborg P, Shore N, Ferreira U, Ivashchenko P, Demirhan E, Modelska K, Phung et al.. (2018) Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer.. N Engl J Med, 378 (26): (2465-2474). [PMID:29949494] [10.1021/op500134e] |
3. Armstrong AJ, Szmulewitz RZ, Petrylak DP, Holzbeierlein J, Villers A, Azad A, Alcaraz A, Alekseev B, Iguchi T, Shore ND et al.. (2019) ARCHES: A Randomized, Phase III Study of Androgen Deprivation Therapy With Enzalutamide or Placebo in Men With Metastatic Hormone-Sensitive Prostate Cancer.. J Clin Oncol, 37 (32): (2974-2986). [PMID:31329516] [10.1021/op500134e] |
4. Jiang, Zhihui Z, Zhou, Bo B, Li, Xinping X, Kirby, Gordon M GM and Zhang, Xiaoying X.. (2018) Echinacoside Increases Sperm Quantity in Rats by Targeting the Hypothalamic Androgen Receptor.. Scientific reports, (1): [PMID:29497114] |