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Enzastaurin (LY317615) - ≥98%, high purity , Protein kinase C beta inhibitor, CAS No.170364-57-5, Protein kinase C beta inhibitor

Moligand™
≥98%

CAS#: 170364-57-5
Formula: C₃₂H₂₉N₅O₂
Molecular Weight: 515.6
PubChem CID: 176167

Item Number

E125760

Grouped product items
SKU	Size	Availability	Price
E125760-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$75.90
E125760-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$151.90
E125760-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$684.90

Potent PKCβ inhibitor

View related series

protein kinase C alpha Inhibitor protein kinase C beta Inhibitor protein kinase C delta Inhibitor protein kinase C gamma Inhibitor

Basic Description

Synonyms	Enzastaurin\|170364-57-5\|LY317615\|Enzastaurin (LY317615)\|3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione\|LY-317615\|3-(1-methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrro
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent PKCβinhibitor (IC50values are 6, 39, 83 and 110 nM for PKCβ, PKCα, PKCγand PKCε, respectively). Suppresses proliferation and induces apoptosis in HCT116 colon carcinoma and U87MG glioblastoma cellsin vitro. Reduces tumor growth and exhibits antiang
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Protein kinase C beta inhibitor
Note	卖完停产，不再备货
Product Description	Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. A potent inhibitor of PKCβ, PKCα, PKCγ and PKCε.

Names and Identifiers

IUPAC Name	3-(1-methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-2,5-dione
INCHI	InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
InChi Key	AXRCEOKUDYDWLF-UHFFFAOYSA-N
Canonical SMILES	CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
Isomeric SMILES	CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7
WGK Germany	3
PubChem CID	176167
Molecular Weight	515.6

CAS Registry No.

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PubChem CID

ChEMBL Ligand

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2 results found

Lot Number	Certificate Type	Date	Item
B1526033	Certificate of Analysis	Jun 12, 2024	E125760
L2325048	Certificate of Analysis	Jan 03, 2024	E125760

Solubility

Solvent:DMSO, Max Conc. mg/mL: 10.31, Max Conc. mM: 20

Sensitivity

Moisture Sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

References

1. Teicher BA, Alvarez E, Menon K, Esterman MA, Considine E, Shih C, Faul MM. (2002) Antiangiogenic effects of a protein kinase Cbeta-selective small molecule.. Cancer Chemother Pharmacol, 49 (1): (69-77). [PMID:11855754]
2. Faul MM, Gillig JR, Jirousek MR, Ballas LM, Schotten T, Kahl A, Mohr M. (2003) Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta.. Bioorg Med Chem Lett, 13 (11): (1857-9). [PMID:12749884]
3. Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN, Banks C, Capen A, Goode R, Lewis JE et al.. (2005) The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.. Cancer Res, 65 (16): (7462-9). [PMID:16103100]

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Enzastaurin (LY317615) - ≥98%, high purity , Protein kinase C beta inhibitor, CAS No.170364-57-5, Protein kinase C beta inhibitor

Basic Description

Product Properties

Names and Identifiers

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