Epetraborole hydrochloride - 99%, high purity , CAS No.1234563-16-6

  • ≥99%
Item Number
E649466
Grouped product items
SKUSizeAvailabilityPrice Qty
E649466-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$70.90
E649466-5mg
5mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$140.90
E649466-10mg
10mg
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$230.90
E649466-25mg
25mg
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$510.90
E649466-50mg
50mg
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$820.90
E649466-100mg
100mg
Available within 8-12 weeks(?)
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$1,320.90

Basic Description

SynonymsBCP18023 | MFCD30343855 | Epetraborole (hydrochloride) | AN3365 (hydrochloride) | UNII-MM0NZY12FA | 1234563-16-6 | EN300-22046930 | EX-A1006 | AN3365(Epetraborole) | 1-Propanol, 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-, h
Specifications & Purity≥99%
Biochemical and Physiological MechanismsEpetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase ( LeuRS ) inhibitor ( IC 50 =0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research
Storage TempStore at 2-8°C,Desiccated
Shipped InWet ice
Product Description

Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase ( LeuRS ) inhibitor ( IC 50 =0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research

In Vitro

Epetraborole (0-32 μg/mL) shows anti-bacterial activity against key gram-negative aerobic and anaerobic pathogens and gram-positive anaerobes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Anaerobes isolates Concentration: 0-32 μg/mL Incubation Time: Result: Showed MIC 50 /MIC 90 for all anaerobes isolates tested of 2 and 4 μg/mL, respectively.

Form:Solid

IC50& Target:IC 50 : 0.31 μM (LeuRS)

Associated Targets(Human)

HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver cytosol (144 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cynomolgus monkey (4946 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 3-[[(3S)-3-(aminomethyl)-1-hydroxy-3H-2,1-benzoxaborol-7-yl]oxy]propan-1-ol;hydrochloride
INCHI InChI=1S/C11H16BNO4.ClH/c13-7-10-8-3-1-4-9(16-6-2-5-14)11(8)12(15)17-10;/h1,3-4,10,14-15H,2,5-7,13H2;1H/t10-;/m1./s1
InChi Key DADYQGIQOBJGIW-HNCPQSOCSA-N
Canonical SMILES B1(C2=C(C=CC=C2OCCCO)C(O1)CN)O.Cl
Isomeric SMILES B1(C2=C(C=CC=C2OCCCO)[C@H](O1)CN)O.Cl
Alternate CAS 1234563-16-6
PubChem CID 52918389
Molecular Weight 273.52

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO : 200 mg/mL (731.21 mM; Need ultrasonic) H2O : ≥ 28 mg/mL (102.37 mM)

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