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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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E649466-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $70.90 | |
E649466-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $140.90 | |
E649466-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $230.90 | |
E649466-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $510.90 | |
E649466-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $820.90 | |
E649466-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,320.90 |
Synonyms | BCP18023 | MFCD30343855 | Epetraborole (hydrochloride) | AN3365 (hydrochloride) | UNII-MM0NZY12FA | 1234563-16-6 | EN300-22046930 | EX-A1006 | AN3365(Epetraborole) | 1-Propanol, 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-, h |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase ( LeuRS ) inhibitor ( IC 50 =0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research |
Storage Temp | Store at 2-8°C,Desiccated |
Shipped In | Wet ice |
Product Description | Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase ( LeuRS ) inhibitor ( IC 50 =0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research In Vitro Epetraborole (0-32 μg/mL) shows anti-bacterial activity against key gram-negative aerobic and anaerobic pathogens and gram-positive anaerobes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Anaerobes isolates Concentration: 0-32 μg/mL Incubation Time: Result: Showed MIC 50 /MIC 90 for all anaerobes isolates tested of 2 and 4 μg/mL, respectively. Form:Solid IC50& Target:IC 50 : 0.31 μM (LeuRS) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-[[(3S)-3-(aminomethyl)-1-hydroxy-3H-2,1-benzoxaborol-7-yl]oxy]propan-1-ol;hydrochloride |
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INCHI | InChI=1S/C11H16BNO4.ClH/c13-7-10-8-3-1-4-9(16-6-2-5-14)11(8)12(15)17-10;/h1,3-4,10,14-15H,2,5-7,13H2;1H/t10-;/m1./s1 |
InChi Key | DADYQGIQOBJGIW-HNCPQSOCSA-N |
Canonical SMILES | B1(C2=C(C=CC=C2OCCCO)C(O1)CN)O.Cl |
Isomeric SMILES | B1(C2=C(C=CC=C2OCCCO)[C@H](O1)CN)O.Cl |
Alternate CAS | 1234563-16-6 |
PubChem CID | 52918389 |
Molecular Weight | 273.52 |
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Solubility | DMSO : 200 mg/mL (731.21 mM; Need ultrasonic) H2O : ≥ 28 mg/mL (102.37 mM) |
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