Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E130023-50mg | 50mg | In stock | $10.90 | |
E130023-250mg | 250mg | In stock | $35.90 | |
E130023-1g | 1g | In stock | $120.90 | |
E130023-5g | 5g | In stock | $390.90 | |
E130023-25g | 25g | In stock | $1,500.90 | |
E130023-100g | 100g | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $5,500.90 |
Synonyms | .alpha. Catechin | A12043 | KBio2_005775 | 1,2-Ethanedisulfonicacid | 2-(3,4-Dihydroxyphenyl)-2,3,4-trihydro-3,5,7-trihydroxychromene | Acacatechin | Spectrum_000159 | CCG-38571 | CCRIS 7097 | s4723 | Tetradecanoic acid, 1-methylethyl ester | MFCD00008042 |
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Specifications & Purity | Moligand™, ≥97%(HPLC) |
Biochemical and Physiological Mechanisms | Epicatechin enhances the skeletal muscle structure in heart failure patients and minimizes cardiometabolic risks. It can be used for treating sarcopenia. Epicatechin reduces myostatin and β-galactosidase and increases the level of markers of muscle growth |
Source | Tea |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Product Description | Epicatechin is a flavanol. Cacao products are rich in epicatechin. Epicatechin enhances the skeletal muscle structure in heart failure patients and minimises the cardiometabolic risks. It can be used for treating sarcopenia. Epicatechin reduces myostatin and β-galactosidase and increases the level of markers of muscle growth. Product description: (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. Application: (−)-Epicatechin (EC) has been used: as an antioxidant to downregulate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase and improve insulin sensitivity in in vivo (high fat-fed mice) and in vitro (HepG2 cells) studies to study its effect on blood pressure, nitric oxide synthase (NOS) activity and anxiety-like behavior on borderline hypertensive rat (BHR) models to test its effect on neuronal survival in the hippocampus of middle-aged rats on swimming training, under oxidative stress to study its antioxidant activity in dark chocolate as a characteristic compound in polyphenols analysis |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488184683 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488184683 |
IUPAC Name | (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol |
INCHI | InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1 |
InChi Key | PFTAWBLQPZVEMU-UKRRQHHQSA-N |
Canonical SMILES | C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O |
Isomeric SMILES | C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O |
WGK Germany | 3 |
RTECS | KB3745000 |
Alternate CAS | 490-46-0,17334-50-8 |
PubChem CID | 72276 |
MeSH Entry Terms | (+)-Catechin;(+)-Cyanidanol;(+)-Cyanidanol-3;(-)-Epicatechin;(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol;2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-cis)-;3,3',4',5,7-Flavanpentol;Catechin;Catechinic Acid;Catechuic Acid; |
Molecular Weight | 290.27 |
Beilstein | 92760 |
PubChem SID | 488184683 |
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Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2425454 | Certificate of Analysis | Sep 23, 2024 | E130023 |
J2425452 | Certificate of Analysis | Sep 23, 2024 | E130023 |
J2425451 | Certificate of Analysis | Sep 23, 2024 | E130023 |
C2430071 | Certificate of Analysis | Mar 18, 2024 | E130023 |
C2430072 | Certificate of Analysis | Mar 18, 2024 | E130023 |
C2430073 | Certificate of Analysis | Mar 18, 2024 | E130023 |
C2430074 | Certificate of Analysis | Mar 18, 2024 | E130023 |
C2430075 | Certificate of Analysis | Mar 18, 2024 | E130023 |
J2412077 | Certificate of Analysis | Mar 18, 2024 | E130023 |
L2327055 | Certificate of Analysis | Nov 26, 2022 | E130023 |
L2315046 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D2314453 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D2314143 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D2314142 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D2314128 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D2314023 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D2314022 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D23131208 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D23131190 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D23131165 | Certificate of Analysis | Nov 26, 2022 | E130023 |
D23131134 | Certificate of Analysis | Nov 26, 2022 | E130023 |
K2203380 | Certificate of Analysis | Nov 12, 2022 | E130023 |
K2203382 | Certificate of Analysis | Nov 12, 2022 | E130023 |
K2203383 | Certificate of Analysis | Nov 12, 2022 | E130023 |
K2203384 | Certificate of Analysis | Nov 12, 2022 | E130023 |
K2203379 | Certificate of Analysis | Oct 26, 2022 | E130023 |
K2203381 | Certificate of Analysis | Oct 26, 2022 | E130023 |
C2215299 | Certificate of Analysis | Mar 19, 2022 | E130023 |
Solubility | Soluble in acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~12.5 mg/ml), and water (partly)., Soluble in acetone:water (1:1, 10 mg/ml), DMSO (100 mM), methanol, DMF (~12.5 mg/ml), and water (partly)., |
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Sensitivity | heat & air sensitive |
Specific Rotation[α] | -62° (C=0.1,MeOH) |
Melt Point(°C) | 240°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | KB3745000 |
1. Yuqing Zhong, Yongling Lu, Lishuang Lv. (2023) Theanine in Tea: An Effective Scavenger of Single or Multiple Reactive Carbonyl Species at the Same Time. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (45): (17153–17162). [PMID:37906124] |
2. Yating Guo, Yili Shen, Boya Hu, Huichun Ye, Haowei Guo, Qiang Chu, Ping Chen. (2023) Decoding the Chemical Signatures and Sensory Profiles of Enshi Yulu: Insights from Diverse Tea Cultivars. Plants-Basel, 12 (21): (3707). [PMID:37960063] |
3. Yingyi Huang, Huahong Liu, Xiaohua Zhang, Yuxin Wu, Zhusheng Liu, Yuelan Pang, Renjun Liu, Chun Yang, Jinfang Nie. (2023) Impact of storage time on non-volatile metabolites and fungal communities in Liupao tea using LC-MS based non-targeted metabolomics and high-throughput sequencing. FOOD RESEARCH INTERNATIONAL, 174 (3): (113615). [PMID:37986470] |
4. Hao-Xiang Gao, Nan Chen, Qiang He, Bi Shi, Wei-Cai Zeng. (2024) Effects of structural characteristics of phenolic compounds on oxidation of glycerol trioleate: Action rule and mechanism. FOOD CHEMISTRY, 433 (137361). [PMID:37688816] |
5. Xiaoyu Yang, Zhichun Bi, Chenghui Yin, Shuyi Zhang, Donghui Song, Hui Huang, Yongxin Li. (2024) A colorimetric sensor array based on peroxidase activity nanozyme for the highly efficient differential sensing of tea polyphenols and Tieguanyin adulteration. FOOD CHEMISTRY, 432 (137265). [PMID:37657343] |
6. Cheng Guo, Wangyang Shen, Weiping Jin, Xiwu Jia, Zhili Ji, Jinling Li, Bin Li. (2023) Dynamic Formation of Green Tea Cream and the Identification of Key Components Using the “Knock-Out/Knock-In” Method. Foods, 12 (16): (2987). [PMID:37627986] |
7. Xiao-Hua Zhang, Xiang-Dong Qing, Jing-Jing Zheng, Yan Yu, Jiaojiao Huang, Chao Kang, Zhi Liu. (2023) Aqueous two-phase systems coupled with chemometrics-enhanced HPLC-DAD for simultaneous extraction and determination of flavonoids in honey. Food Chemistry-X, 19 (100766). [PMID:37780266] |
8. Xiaojuan Chen, Bojia Li, Sicheng Ji, Di Wu, Bing Cui, Xingling Ren, Bin Zhou, Bin Li, Hongshan Liang. (2023) Small molecules interfacial assembly regulate the crystallization transition process for nobiletin stabilization. FOOD CHEMISTRY, 426 (136519). [PMID:37329798] |
9. Su Zhou, Jiaying Yang, Yani Pan, Xinyu Feng, Hao Hu, Shicheng Ma, Cansong Ou, Fangyuan Fan, Shuying Gong, Yuefei Wang, Ping Chen, Qiang Chu. (2023) Pu’ er raw tea extract alleviates DSS-induced colitis in mice by restoring intestinal barrier function and maintaining gut microbiota homeostasis. Food Bioscience, 53 (102750). [PMID:] |
10. Chi Zhao, Fengju Zhang, Shanbo Chen, Wen Hu, Ling Dong, Yuejun Zhao, Mei Han, Zhihua Li. (2023) Effects of drying methods on the quality of Hanyuan Zanthoxylum bungeanum based on physicochemical and functional metabolite analysis. LWT-FOOD SCIENCE AND TECHNOLOGY, 180 (114674). [PMID:] |
11. Wang Qiaolin, Xu Lihe, Qin Zhengbo, Yang Xinyan, Zheng Xianfeng. (2023) Potential use of LIAD time-of-flight mass spectrometry for the detection of biomolecules: An example of detecting nucleobases in DNA. AIP Advances, 13 (3): [PMID:] |
12. Fanghua Guo, Li Peng, Hua Xiong, Rong Tsao, Hua Zhang, Li Jiang, Yong Sun. (2023) Bioaccessibility and transport of lentil hull polyphenols in vitro, and their bioavailability and metabolism in rats. FOOD RESEARCH INTERNATIONAL, 167 (112634). [PMID:37087206] |
13. Huiqun Fan, Mingshun Chen, Taotao Dai, Lizhen Deng, Chengmei Liu, Wei Zhou, Jun Chen. (2023) Phenolic compounds profile of Amomum tsaoko Crevost et Lemaire and their antioxidant and hypoglycemic potential. Food Bioscience, 52 (102508). [PMID:] |
14. Jianhui Zhu, Jingyang Yu, Bingjie Zhang, Changsheng Li, Jianli Wang, Jiawen Ji, Desheng Liu, Rumin Gao, Jianzhang Li, Yongqiang Ma. (2023) Hydrophobic-action-driven removal of six organophosphorus pesticides from tea infusion by modified carbonized bacterial cellulose. FOOD CHEMISTRY, 412 (135546). [PMID:36716625] |
15. Lixia Yang, Zhendong Lu, Jian Lu, Dianhui Wu. (2022) Evaluation of the antioxidant characteristics of craft beer with green tea. JOURNAL OF FOOD SCIENCE, 88 (2): (625-637). [PMID:36576119] |
16. Zhangfeng Zhao, Zhengwei Dai, Xuming Jiang, Liaoyuan Yu, Meijuan Hu, Jiyu Peng, Fei Zhou. (2023) Influence and optimization of long-time superfine grinding on the physicochemical features of green tea powder. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 117 (105124). [PMID:] |
17. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2023) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6 (100424). [PMID:36618100] |
18. Han Wang, Lu Chen, Shuang Wu, Weiping Jin, Wangyang Shen, Zhongze Hu, Wenjing Huang, Gang Liu. (2023) Improve stability and application of rice oil bodies via surface modification with ferulic acid, (-)-epicatechin, and phytic acid. FOOD CHEMISTRY, 409 (135274). [PMID:36586252] |
19. Xinyu Fang, Jiali Ma, Chenjie Gu, Wei Xiong, Tao Jiang. (2023) Synchronous enhancement of electromagnetic and chemical effects-induced quantitative adsorptive detection of quercetin based on flexible polymer-silver-ZIF-67 SERS substrate. SENSORS AND ACTUATORS B-CHEMICAL, 378 (133176). [PMID:] |
20. Shuwen Li, Zhiguo Wang, Siyi Chen, Jialin Gu, Yanping Ma, Jiangang Jiang, Rui Zhang, Dan Zhang, Yiping Wang, He Wang. (2023) Ratiometric fluorescence sensing based on rare-earth upconversion nanoparticles for the rapid identification of antioxidant capacity. NEW JOURNAL OF CHEMISTRY, 47 (4): (2079-2085). [PMID:] |
21. Xiao-Hua Zhang, Hui-Na Cui, Jing-Jing Zheng, Xiang-Dong Qing, Kai-Long Yang, Ya-Qian Zhang, Lu-Meng Ren, Le-Yuan Pan, Xiao-Li Yin. (2023) Discrimination of the harvesting season of green tea by alcohol/salt-based aqueous two-phase systems combined with chemometric analysis. FOOD RESEARCH INTERNATIONAL, 163 (112278). [PMID:36596188] |
22. Hui Jiang, Fei Wu, Xi Jiang, Yun-Feng Pu, Li-Rong Shen, Cui-Yun Wu, Hong-Jin Bai. (2022) Antioxidative, cytoprotective and whitening activities of fragrant pear fruits at different growth stages. Frontiers in Nutrition, 9 (1020855). [PMID:36245497] |
23. Yao Fan, Siying Che, Lei Zhang, Chunsong Zhou, Haiyan Fu, Yuanbin She. (2022) Dual channel sensor array based on ZnCdSe QDs – KMnO4: An effective tool for analysis of catechins and green teas. FOOD RESEARCH INTERNATIONAL, 160 (111734). [PMID:36076421] |
24. Guanghe Zhao, Ruifen Zhang, Lihong Dong, Lei Liu, Fei Huang, Xuchao Jia, Mei Deng, Jianwei Chi, Yongxuan Ma, Yanxia Chen, Qin Ma, Mingwei Zhang. (2022) Bound phenolics in rice bran dietary fibre released by different chemical hydrolysis methods: content, composition and antioxidant activities. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (9): (5909-5916). [PMID:] |
25. Su Xuexia, Bai Cuihua, Wang Xianghe, Liu Huilin, Zhu Yongcong, Wei Leping, Cui Zixiao, Yao Lixian. (2022) Potassium Sulfate Spray Promotes Fruit Color Preference via Regulation of Pigment Profile in Litchi Pericarp. Frontiers in Plant Science, 13 [PMID:35774808] |
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27. Wen-Jing He, Nan Chen, Zhi-Long Yu, Qun Sun, Qiang He, Wei-Cai Zeng. (2022) Gliadin interacted with tea polyphenols: potential application and action mechanism. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 73 (6): (786-799). [PMID:35603582] |
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