Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E107403-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $13.90 | |
E107403-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $19.90 | |
E107403-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $59.90 |
Potent antioxidant flavonoid
Synonyms | (-)-Epigallocatechin gallate|EGCG|989-51-5|Epigallocatechin gallate|Epigallocatechin 3-gallate|Tea catechin|Epigallocatechin-3-gallate|Teavigo|Epigallocatechin-3-monogallate|(-)-Epigallocatechin-3-o-gallate|(-)-epigallocatechin 3-gallate|PF-EGCg 90|(-)-Ep |
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Specifications & Purity | Moligand™, analytical standard |
Biochemical and Physiological Mechanisms | (-) Epigallocatechin Gallate sulfonate (EGCG) is a major polyphenol in green tea that can inhibit cell proliferation and induce cell apoptosis. (-) Epigallocatechin Gallate sulfate can inhibit the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2). |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
Shipped In | Wet ice |
Grade | analytical standard, Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | (-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS). |
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IUPAC Name | [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate |
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INCHI | InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1 |
InChi Key | WMBWREPUVVBILR-WIYYLYMNSA-N |
Canonical SMILES | C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
Isomeric SMILES | C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
WGK Germany | 2 |
RTECS | KB5200000 |
PubChem CID | 65064 |
UN Number | 3077 |
Packing Group | III |
Molecular Weight | 458.37 |
Beilstein | 17(5)8,506 |
Reaxy-Rn | 67944 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2215629 | Certificate of Analysis | Aug 23, 2024 | E107403 |
L2215630 | Certificate of Analysis | Aug 23, 2024 | E107403 |
G2214191 | Certificate of Analysis | Apr 07, 2024 | E107403 |
G2214192 | Certificate of Analysis | Apr 07, 2024 | E107403 |
H2318413 | Certificate of Analysis | Aug 23, 2023 | E107403 |
H2318414 | Certificate of Analysis | Aug 22, 2023 | E107403 |
H2318415 | Certificate of Analysis | Aug 22, 2023 | E107403 |
H2318412 | Certificate of Analysis | Aug 22, 2023 | E107403 |
H2318416 | Certificate of Analysis | Aug 22, 2023 | E107403 |
G2214193 | Certificate of Analysis | Jun 09, 2022 | E107403 |
Solubility | Soluble in ethanol (~20 mg/ml), dimethyl formamide (~20 mg/ml), DMSO (~20 mg/ml), water (>5 mg/ml), DMF, PBS pH 7.2, and Methanol. |
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Sensitivity | Air sensitive,Light sensitive |
Specific Rotation[α] | -175.5 ° (C=1, EtOH) |
Melt Point(°C) | 212°C |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H317:May cause an allergic skin reaction H312:Harmful in contact with skin H401:Toxic to aquatic life |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 2 |
RTECS | KB5200000 |
Reaxy-Rn | 67944 |
Class | 9 |
Merck Index | 3526 |
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