Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E107404-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $43.90 | |
E107404-500mg | 500mg | In stock | $129.90 | |
E107404-2.5g | 2.5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $389.90 |
β-secretase (BACE) inhibitor; inhibits amyloid assembly
Synonyms | (-)-Epigallocatechin gallate | EGCG | 989-51-5 | Epigallocatechin gallate | Epigallocatechin 3-gallate | Tea catechin | Epigallocatechin-3-gallate | Teavigo | Epigallocatechin-3-monogallate | (-)-Epigallocatechin-3-o-gallate | (-)-epigallocatechin 3-gallate | PF-EGCg 90 | (-)-Ep |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | β-secretase (BACE1) inhibitor (IC50= 1.6μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ,α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate de |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST, INHIBITOR |
Mechanism of action | Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B |
Product Description | (-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS). |
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IUPAC Name | [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate |
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INCHI | InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1 |
InChi Key | WMBWREPUVVBILR-WIYYLYMNSA-N |
Canonical SMILES | C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
Isomeric SMILES | C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O |
WGK Germany | 2 |
RTECS | KB5200000 |
PubChem CID | 65064 |
UN Number | 3077 |
Packing Group | III |
Molecular Weight | 458.37 |
Beilstein | 17(5)8,506 |
Reaxy-Rn | 67944 |
PubChem CID | 65064 |
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CAS Registry No. | 989-51-5 |
ChEMBL Ligand | CHEMBL297453 |
Wikipedia | Epigallocatechin_gallate |
ChEBI | CHEBI:4806 |
BitterDB Ligand | 808 |
RCSB PDB Ligand | EGG, KDH |
Antibiotic DB | 1416 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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D2416252 | Certificate of Analysis | Apr 25, 2024 | E107404 |
D2416253 | Certificate of Analysis | Apr 25, 2024 | E107404 |
L2318272 | Certificate of Analysis | Dec 25, 2023 | E107404 |
L2318273 | Certificate of Analysis | Dec 25, 2023 | E107404 |
G2214193 | Certificate of Analysis | Nov 27, 2023 | E107404 |
G2214194 | Certificate of Analysis | Nov 27, 2023 | E107404 |
G2214195 | Certificate of Analysis | Nov 27, 2023 | E107404 |
J2308484 | Certificate of Analysis | Nov 16, 2023 | E107404 |
J2308485 | Certificate of Analysis | Nov 16, 2023 | E107404 |
J2308486 | Certificate of Analysis | Nov 16, 2023 | E107404 |
L2215539 | Certificate of Analysis | Jan 03, 2023 | E107404 |
L2215631 | Certificate of Analysis | Jan 03, 2023 | E107404 |
L2215632 | Certificate of Analysis | Jan 03, 2023 | E107404 |
L2116394 | Certificate of Analysis | Dec 20, 2021 | E107404 |
Solubility | Solvent:water, Max Conc. mg/mL: 4.58, Max Conc. mM: 10; Solvent:DMSO, Max Conc. mg/mL: 45.84, Max Conc. mM: 100 |
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Sensitivity | Light Sensitive;Air sensitive |
Specific Rotation[α] | -175.5 ° (C=1, EtOH) |
Melt Point(°C) | 212°C |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H317:May cause an allergic skin reaction H312:Harmful in contact with skin H401:Toxic to aquatic life |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 2 |
RTECS | KB5200000 |
Reaxy-Rn | 67944 |
Class | 9 |
Merck Index | 3526 |
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23. Guo Cheng, Shen Wangyang, Jin Weiping, Jia Xiwu, Ji Zhili, Jinling Li, Bin Li. (2023) Effects of epigallocatechin gallate, caffeine and their combination on fat accumulation in high-glucose diet-fed Caenorhabditis elegans. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, [PMID:37363872] |
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