(-)-Epigallocatechin gallate - 98%, high purity , CAS No.989-51-5, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B
(-)-Epigallocatechin gallate - 98%, high purity , CAS No.989-51-5, Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B
β-secretase (BACE1) inhibitor (IC50= 1.6μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ,α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate de
Storage Temp
Store at 2-8°C,Protected from light,Argon charged
Shipped In
Wet ice
Grade
Moligand™
Action Type
AGONIST, INHIBITOR
Mechanism of action
Inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A;Inhibitor of E1A binding protein p300;Agonist of TAS2R5;Inhibitor of lysine acetyltransferase 2B
Product Description
(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS). An inhibitor of Bcl-2 and NOS2
1.Carneiro BM, Batista MN, Braga ACS, Nogueira ML, Rahal P. (2016) The green tea molecule EGCG inhibits Zika virus entry.. Virology, 496 (3):(215-218). [PMID:27344138]
2.Reid SP, Shurtleff AC, Costantino JA, Tritsch SR, Retterer C, Spurgers KB, Bavari S. (2014) HSPA5 is an essential host factor for Ebola virus infection.. Antiviral Res, 109 (3):(171-4). [PMID:25017472]
3.Tallei TE, Tumilaar SG, Niode NJ, Fatimawali, Kepel BJ, Idroes R, Effendi Y, Sakib SA, Emran TB. (2020) Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (Mpro) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study.. Scientifica (Cairo), 2020 (3):(6307457). [PMID:33425427]
4.Lu JW, Hsieh PS, Lin CC, Hu MK, Huang SM, Wang YM, Liang CY, Gong Z, Ho YJ. (2017) Synergistic effects of combination treatment using EGCG and suramin against the chikungunya virus.. Biochem Biophys Res Commun, 491 (3):(595-602). [PMID:28760340]
5.Chourasia M, Koppula PR, Battu A, Ouseph MM, Singh AK. (2021) EGCG, a Green Tea Catechin, as a Potential Therapeutic Agent for Symptomatic and Asymptomatic SARS-CoV-2 Infection.. Molecules, 26 (5):(1200). [PMID:33668085]
6.Raekiansyah M, Buerano CC, Luz MAD, Morita K. (2018) Inhibitory effect of the green tea molecule EGCG against dengue virus infection.. Arch Virol, 163 (6):(1649-1655). [PMID:29429035]
7.Ge M, Xiao Y, Chen H, Luo F, Du G, Zeng F. (2018) Multiple antiviral approaches of (-)-epigallocatechin-3-gallate (EGCG) against porcine reproductive and respiratory syndrome virus infection in vitro.. Antiviral Res, 158 (3):(52-62). [PMID:30048655]
8.Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N et al.. (2017) Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.. Nat Commun, 8 (1):(1527). [PMID:29142305]
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