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Epigenetic Multiple Ligand , CAS No.1020399-52-3
a cell-permeable bis-arylidene compound
Basic Description Storage Temp Store at 2-8°C Shipped In Wet ice Product Description Epigenetic Multiple Ligand is a cell-permeable bis-arylidene compound that acts as an epi-ML and inhibits substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1, with weak effect on the process of Np13p by PRMT1. Epigenetic Multiple Ligand has been shown to induce either apoptosis or granulocytic differentiation among U937 cell population. It is an inhibitor of PRMT.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (3E,5E)-3,5-bis[(3,5-dibromo-4-hydroxyphenyl)methylidene]oxan-4-one INCHI InChI=1S/C19H12Br4O4/c20-13-3-9(4-14(21)18(13)25)1-11-7-27-8-12(17(11)24)2-10-5-15(22)19(26)16(23)6-10/h1-6,25-26H,7-8H2/b11-1+,12-2+ InChi Key JEDNMNJCJIIYJR-NJDSBKIZSA-N Canonical SMILES C1C(=CC2=CC(=C(C(=C2)Br)O)Br)C(=O)C(=CC3=CC(=C(C(=C3)Br)O)Br)CO1 Isomeric SMILES C\1OC/C(=C\C2=CC(=C(C(=C2)Br)O)Br)/C(=O)/C1=C/C3=CC(=C(C(=C3)Br)O)Br PubChem CID 24827562 Molecular Weight 623.9
Chemical and Physical Properties Solubility Soluble in DMSO (100 mg/ml). Refractive Index n20D1.77 (Predicted) Boil Point(°C) 615.56° C at 760 mmHg (Predicted)
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