Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E129934-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $86.90 | |
E129934-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $255.90 | |
E129934-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $921.90 | |
E129934-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,036.90 | |
E129934-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $3,732.90 | |
E129934-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $16,796.90 |
Selective mineralocorticoid antagonist
Synonyms | 6995V82D0B | D01115 | HSDB 7522 | DTXSID2046094 | C03DA04 | Epoxymexrenone | C24H30O6 | Inspra (TN) | NCGC00159559-03 | US9138393, 6-Chloropurine | UNII-6995V82D0B | DB00700 | EPLERENONE [WHO-DD] | BE164415 | CCG-268820 | EPLERENONE (MART.) | EPLER |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Eplerenone is an aldosterone antagonist with more specificity for the mineralocorticoid receptor (MCR) than spironolactone, having lower affinity for progesterone, androgen, and glucocorticoid receptors.Selective mineralocorticoid (aldosterone) antagonist |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Mineralocorticoid receptor antagonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM. |
ALogP | 1.4 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate |
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INCHI | InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1 |
InChi Key | JUKPWJGBANNWMW-VWBFHTRKSA-N |
Canonical SMILES | CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC |
Isomeric SMILES | C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC |
WGK Germany | 3 |
PubChem CID | 443872 |
Molecular Weight | 414.49 |
PubChem CID | 443872 |
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DrugBank Ligand | DB00700 |
BindingDB Ligand | 50324120 |
CAS Registry No. | 107724-20-9 |
ChEBI | CHEBI:31547 |
Wikipedia | Eplerenone |
ChEMBL Ligand | CHEMBL1095097 |
PEP | eplerenone |
RCSB PDB Ligand | YNU, YNU |
DrugCentral Ligand | 1032 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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F2125305 | Certificate of Analysis | Apr 13, 2023 | E129934 |
F2125254 | Certificate of Analysis | Apr 13, 2023 | E129934 |
F2125249 | Certificate of Analysis | Apr 13, 2023 | E129934 |
F2125250 | Certificate of Analysis | Apr 13, 2023 | E129934 |
F2125255 | Certificate of Analysis | Apr 13, 2023 | E129934 |
F2125259 | Certificate of Analysis | Apr 13, 2023 | E129934 |
G1520066 | Certificate of Analysis | Feb 03, 2023 | E129934 |
Solubility | Soluble in DMSO (10 mM), water (very slightly), ethanol (slightly), methanol (sparingly), and chloroform. |
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Sensitivity | Heat sensitive |
Melt Point(°C) | 242 °C(dec.) |
Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed H317:May cause an allergic skin reaction H312:Harmful in contact with skin H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Merck Index | 3625 |