Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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E275302-10mg | 10mg | In stock | $157.90 | |
E275302-50mg | 50mg | In stock | $691.90 | |
E275302-250mg | 250mg | In stock | $3,114.90 |
Novel, selective, highly potent TAAR1 antagonist
Synonyms | (N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide | GTPL5457 | BDBM50336205 | N-(3-ethoxyphenyl)-4-(pyrrolidin-1-yl)-3-(trifluoromethyl)benzamide | Ro 5212773 | AS-53746 | N-(3-ethoxyphenyl)-4-pyrrolidin-1-yl-3-(trifluoromethyl)benzamide |
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Specifications & Purity | Moligand™, ≥95% |
Biochemical and Physiological Mechanisms | Novel, selective, highly potent trace amine associated receptor 1 (TAAR1) antagonist. Higher potency in mouse than rat and human (IC50 values are 28nM, 4539nM and 7487nM, respectively). Increases firing frequency of dopamine (DA)neurons in ventral tegment |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of TA 1 receptor |
Note | Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Shipped at Room Temperature. Store at -21°C. Please see notes section. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N-(3-ethoxyphenyl)-4-pyrrolidin-1-yl-3-(trifluoromethyl)benzamide |
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INCHI | InChI=1S/C20H21F3N2O2/c1-2-27-16-7-5-6-15(13-16)24-19(26)14-8-9-18(25-10-3-4-11-25)17(12-14)20(21,22)23/h5-9,12-13H,2-4,10-11H2,1H3,(H,24,26) |
InChi Key | KLFVWQCQUXXLOU-UHFFFAOYSA-N |
Canonical SMILES | CCOC1=CC=CC(=C1)NC(=O)C2=CC(=C(C=C2)N3CCCC3)C(F)(F)F |
Isomeric SMILES | CCOC1=CC=CC(=C1)NC(=O)C2=CC(=C(C=C2)N3CCCC3)C(F)(F)F |
PubChem CID | 25175634 |
Molecular Weight | 378.39 |
CAS Registry No. | 1110781-88-8 |
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PubChem CID | 25175634 |
ChEMBL Ligand | CHEMBL1669669 |
GPCRdb Ligand | EPPTB |
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Solubility | Soluble in DMSO to 50mM |
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RIDADR | NONHforallmodesoftransport |
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