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Home Epigenetics EPZ 004777 - 10mM in DMSO, high purity , CAS No.1338466-77-5
EPZ 004777 - 10mM in DMSO, high purity , CAS No.1338466-77-5
Highly potent DOT1L inhibitor
Basic Description Synonyms EPZ004777 | 1338466-77-5 | 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea | EPZ 004777 | CHEMBL2169919 | 7-{5-[(3-{[(4-Tert-Butylphenyl)carbamoyl]amino Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Highly potent DOT1L inhibitor (IC50= 0.4 nM). Exhibits >1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits proliferation and induces apoptosis ofMLL-rearranged cellsin vitro. Prolongs survival in a MLL xenograft Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 1-[3-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea INCHI InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21-,22-,23-,26-/m1/s1 InChi Key WXRGFPHDRFQODR-ICLZECGLSA-N Canonical SMILES CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C(N=CN=C43)N)O)O Isomeric SMILES CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C(N=CN=C43)N)O)O PubChem CID 56962336 Molecular Weight 539.67
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