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Home Epigenetics EPZ015666 - 10mM in DMSO, high purity , CAS No.1616391-65-1
EPZ015666 - 10mM in DMSO, high purity , CAS No.1616391-65-1
Selective, potent PRMT5 inhibitor
Basic Description Synonyms (S)-N-(3-(3，4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide，GSK3235025，YQ36286 Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Selective, potent (IC 50 = 22nM, K i =5 nM) inhibitor of arginine methyltransferase 5 (PRMT5). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide INCHI InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1 InChi Key ZKXZLIFRWWKZRY-KRWDZBQOSA-N Canonical SMILES C1CN(CC2=CC=CC=C21)CC(CNC(=O)C3=CC(=NC=N3)NC4COC4)O Isomeric SMILES C1CN(CC2=CC=CC=C21)C[C@H](CNC(=O)C3=CC(=NC=N3)NC4COC4)O PubChem CID 90241673 Molecular Weight 383.44
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