Erastin - ≥99%, high purity , CAS No.571203-78-6

  • ≥99%
Item Number
E126853
Grouped product items
SKUSizeAvailabilityPrice Qty
E126853-5mg
5mg
In stock
$112.90
E126853-25mg
25mg
In stock
$399.90
E126853-100mg
100mg
In stock
$999.90
E126853-500mg
500mg
In stock
$3,499.90

Selective ferrotopsis activator

Basic Description

Synonyms2-(1-(4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one | MFCD09837984 | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone | 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-1-pipera
Specifications & Purity≥99%
Biochemical and Physiological MechanismsDescription:IC50 Value: 0.1 uM (VDAC-2) [1]Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers.V
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
NoteNeed more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc-.


Application:

Erastin has been used:
as a positive control for inducing ferroptosis in hepatic stellate cell (HSC)
to induce ferroptosis and in transferrin internalization assay of human fibrosarcoma HT1080 cells
to induce ferroptosis of muscle-derived cell lines

Associated Targets(Human)

SLC7A11 Tchem Cystine/glutamate transporter (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDAC2 Tchem Voltage-dependent anion-selective channel protein 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
A673 (619 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calu-1 (518 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-1080 (3966 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-N-MC (815 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-937 (7138 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BJ (6930 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOS (906 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-ES1 (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP (8286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver (3974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDAC2 Tchem Voltage-dependent anion-selective channel protein 2 (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC7A11 Tchem Cystine/glutamate transporter (150 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAPK3 Tchem Mitogen-activated protein kinase; ERK1/ERK2 (651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-LMS-1 (121 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW982 (212 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SJSA-1 (970 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW872 (162 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C-33-A (287 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SVR (53 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one
INCHI InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
InChi Key BKQFRNYHFIQEKN-UHFFFAOYSA-N
Canonical SMILES CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl
Isomeric SMILES CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl
WGK Germany 3
PubChem CID 11214940
Molecular Weight 547.04

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot NumberCertificate TypeDateItem
L2205572Certificate of AnalysisSep 12, 2024 E126853
L2205573Certificate of AnalysisSep 12, 2024 E126853
G2430349Certificate of AnalysisJun 21, 2024 E126853
G2430350Certificate of AnalysisJun 21, 2024 E126853
G2430351Certificate of AnalysisJun 21, 2024 E126853
C2426003Certificate of AnalysisAug 10, 2023 E126853
H2328430Certificate of AnalysisAug 10, 2023 E126853
H2328431Certificate of AnalysisAug 10, 2023 E126853
H2328432Certificate of AnalysisAug 10, 2023 E126853
L2205441Certificate of AnalysisNov 22, 2022 E126853
L2205576Certificate of AnalysisNov 22, 2022 E126853
F2209101Certificate of AnalysisMay 19, 2022 E126853
F2209128Certificate of AnalysisMay 19, 2022 E126853
F2209175Certificate of AnalysisMay 19, 2022 E126853
F2209177Certificate of AnalysisMay 19, 2022 E126853
C2221030Certificate of AnalysisMar 24, 2022 E126853

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Chemical and Physical Properties

Solubility25°C: DMSO
Sensitivityair & heat sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

WGK Germany 3

Related Documents

Citations of This Product

1. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang.  (2023)  TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin.  JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,      [PMID:] [10.1080/01932691.2023.2295024]
2. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo.  (2024)  Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease.  JOURNAL OF ETHNOPHARMACOLOGY,  319  (23): (117196).  [PMID:37717841] [10.1016/j.jep.2023.117196]
3. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He.  (2023)  Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway.  EUROPEAN JOURNAL OF PHARMACOLOGY,    (176009).  [PMID:37619784] [10.1016/j.ejphar.2023.176009]
4. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng.  (2023)  Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress.  JOURNAL OF ETHNOPHARMACOLOGY,  316  (116729).  [PMID:37277081] [10.1016/j.jep.2023.116729]
5. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun.  (2023)  CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy.  Acta Biomaterialia,  166  (604).  [PMID:37156432] [10.1016/j.actbio.2023.05.006]
6. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji.  (2023)  Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma.  Frontiers in Genetics,  14    [PMID:36733341] [10.3389/fgene.2023.1099272]
7. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang.  (2023)  Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis.  Molecular Medicine Reports,  27  (2): (1-11).  [PMID:36601753] [10.3892/mmr.2023.12931]
8. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu.  (2022)  Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis.  PHARMACEUTICAL BIOLOGY,  60  (1): (909-914).  [PMID:35575436] [10.1080/13880209.2022.2066139]
9. Xiazhen Bao, Xuehui Cao, Yong Yuan, Bo Zhou, Congde Huo.  (2021)  A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid.  SENSORS AND ACTUATORS B-CHEMICAL,  344  (130210).  [PMID:] [10.1016/j.snb.2021.130210]
10. Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu.  (2021)  Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.  FEBS Open Bio,  11  (8): (2118-2126).  [PMID:34048148] [10.1002/2211-5463.13203]
11. Zhu Yiming, Zhang Chihao, Huang Mingzhe, Lin Jiayun, Fan Xiao, Ni Tao.  (2021)  TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination.  Frontiers in Cell and Developmental Biology,    [PMID:33869196] [10.3389/fcell.2021.644901]

References

1. Torii S et al..  (2016)  An essential role for functional lysosomes in ferroptosis of cancer cells..  Biochem J,      [PMID:26759376]
2. Chen L et al..  (2021)  Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas..  Front Immunol,  12  (739039).  [PMID:35185859]
3. Xie Y et al..  (2016)  Ferroptosis: process and function..  Cell Death Differ,      [PMID:26794443]
4. Simamura E et al..  (2008)  Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents..  J Bioenerg Biomembr,  40  (3): (213-7).  [PMID:18704666]
5. Haß C et al..  (2016)  Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis..  Biochem Pharmacol,      [PMID:26774450]
6. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang.  (2023)  TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin.  JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,      [PMID:] [10.1080/01932691.2023.2295024]
7. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo.  (2024)  Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease.  JOURNAL OF ETHNOPHARMACOLOGY,  319  (23): (117196).  [PMID:37717841] [10.1016/j.jep.2023.117196]
8. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He.  (2023)  Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway.  EUROPEAN JOURNAL OF PHARMACOLOGY,    (176009).  [PMID:37619784] [10.1016/j.ejphar.2023.176009]
9. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng.  (2023)  Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress.  JOURNAL OF ETHNOPHARMACOLOGY,  316  (116729).  [PMID:37277081] [10.1016/j.jep.2023.116729]
10. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun.  (2023)  CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy.  Acta Biomaterialia,  166  (604).  [PMID:37156432] [10.1016/j.actbio.2023.05.006]
11. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji.  (2023)  Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma.  Frontiers in Genetics,  14    [PMID:36733341] [10.3389/fgene.2023.1099272]
12. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang.  (2023)  Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis.  Molecular Medicine Reports,  27  (2): (1-11).  [PMID:36601753] [10.3892/mmr.2023.12931]
13. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu.  (2022)  Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis.  PHARMACEUTICAL BIOLOGY,  60  (1): (909-914).  [PMID:35575436] [10.1080/13880209.2022.2066139]
14. Xiazhen Bao, Xuehui Cao, Yong Yuan, Bo Zhou, Congde Huo.  (2021)  A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid.  SENSORS AND ACTUATORS B-CHEMICAL,  344  (130210).  [PMID:] [10.1016/j.snb.2021.130210]
15. Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu.  (2021)  Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.  FEBS Open Bio,  11  (8): (2118-2126).  [PMID:34048148] [10.1002/2211-5463.13203]
16. Zhu Yiming, Zhang Chihao, Huang Mingzhe, Lin Jiayun, Fan Xiao, Ni Tao.  (2021)  TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination.  Frontiers in Cell and Developmental Biology,    [PMID:33869196] [10.3389/fcell.2021.644901]

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