Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E126853-5mg | 5mg | In stock | $112.90 | |
E126853-25mg | 25mg | In stock | $399.90 | |
E126853-100mg | 100mg | In stock | $999.90 | |
E126853-500mg | 500mg | In stock | $3,499.90 |
Selective ferrotopsis activator
Synonyms | 2-(1-(4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one | MFCD09837984 | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone | 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-1-pipera |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Description:IC50 Value: 0.1 uM (VDAC-2) [1]Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers.V |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Note | Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc-. Application: Erastin has been used: |
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IUPAC Name | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one |
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INCHI | InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3 |
InChi Key | BKQFRNYHFIQEKN-UHFFFAOYSA-N |
Canonical SMILES | CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl |
Isomeric SMILES | CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl |
WGK Germany | 3 |
PubChem CID | 11214940 |
Molecular Weight | 547.04 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L2205572 | Certificate of Analysis | Sep 12, 2024 | E126853 |
L2205573 | Certificate of Analysis | Sep 12, 2024 | E126853 |
G2430349 | Certificate of Analysis | Jun 21, 2024 | E126853 |
G2430350 | Certificate of Analysis | Jun 21, 2024 | E126853 |
G2430351 | Certificate of Analysis | Jun 21, 2024 | E126853 |
C2426003 | Certificate of Analysis | Aug 10, 2023 | E126853 |
H2328430 | Certificate of Analysis | Aug 10, 2023 | E126853 |
H2328431 | Certificate of Analysis | Aug 10, 2023 | E126853 |
H2328432 | Certificate of Analysis | Aug 10, 2023 | E126853 |
L2205441 | Certificate of Analysis | Nov 22, 2022 | E126853 |
L2205576 | Certificate of Analysis | Nov 22, 2022 | E126853 |
F2209101 | Certificate of Analysis | May 19, 2022 | E126853 |
F2209128 | Certificate of Analysis | May 19, 2022 | E126853 |
F2209175 | Certificate of Analysis | May 19, 2022 | E126853 |
F2209177 | Certificate of Analysis | May 19, 2022 | E126853 |
C2221030 | Certificate of Analysis | Mar 24, 2022 | E126853 |
Solubility | 25°C: DMSO |
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Sensitivity | air & heat sensitive |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
WGK Germany | 3 |
Starting at $241.90
1. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2023) TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID:] [10.1080/01932691.2023.2295024] |
2. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo. (2024) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease. JOURNAL OF ETHNOPHARMACOLOGY, 319 (23): (117196). [PMID:37717841] [10.1016/j.jep.2023.117196] |
3. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He. (2023) Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, (176009). [PMID:37619784] [10.1016/j.ejphar.2023.176009] |
4. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng. (2023) Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress. JOURNAL OF ETHNOPHARMACOLOGY, 316 (116729). [PMID:37277081] [10.1016/j.jep.2023.116729] |
5. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun. (2023) CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy. Acta Biomaterialia, 166 (604). [PMID:37156432] [10.1016/j.actbio.2023.05.006] |
6. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji. (2023) Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma. Frontiers in Genetics, 14 [PMID:36733341] [10.3389/fgene.2023.1099272] |
7. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang. (2023) Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis. Molecular Medicine Reports, 27 (2): (1-11). [PMID:36601753] [10.3892/mmr.2023.12931] |
8. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu. (2022) Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis. PHARMACEUTICAL BIOLOGY, 60 (1): (909-914). [PMID:35575436] [10.1080/13880209.2022.2066139] |
9. Xiazhen Bao, Xuehui Cao, Yong Yuan, Bo Zhou, Congde Huo. (2021) A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid. SENSORS AND ACTUATORS B-CHEMICAL, 344 (130210). [PMID:] [10.1016/j.snb.2021.130210] |
10. Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu. (2021) Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway. FEBS Open Bio, 11 (8): (2118-2126). [PMID:34048148] [10.1002/2211-5463.13203] |
11. Zhu Yiming, Zhang Chihao, Huang Mingzhe, Lin Jiayun, Fan Xiao, Ni Tao. (2021) TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination. Frontiers in Cell and Developmental Biology, 9 [PMID:33869196] [10.3389/fcell.2021.644901] |
1. Torii S et al.. (2016) An essential role for functional lysosomes in ferroptosis of cancer cells.. Biochem J, [PMID:26759376] |
2. Chen L et al.. (2021) Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas.. Front Immunol, 12 (739039). [PMID:35185859] |
3. Xie Y et al.. (2016) Ferroptosis: process and function.. Cell Death Differ, [PMID:26794443] |
4. Simamura E et al.. (2008) Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents.. J Bioenerg Biomembr, 40 (3): (213-7). [PMID:18704666] |
5. Haß C et al.. (2016) Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis.. Biochem Pharmacol, [PMID:26774450] |
6. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2023) TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID:] [10.1080/01932691.2023.2295024] |
7. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo. (2024) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease. JOURNAL OF ETHNOPHARMACOLOGY, 319 (23): (117196). [PMID:37717841] [10.1016/j.jep.2023.117196] |
8. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He. (2023) Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, (176009). [PMID:37619784] [10.1016/j.ejphar.2023.176009] |
9. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng. (2023) Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress. JOURNAL OF ETHNOPHARMACOLOGY, 316 (116729). [PMID:37277081] [10.1016/j.jep.2023.116729] |
10. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun. (2023) CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy. Acta Biomaterialia, 166 (604). [PMID:37156432] [10.1016/j.actbio.2023.05.006] |
11. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji. (2023) Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma. Frontiers in Genetics, 14 [PMID:36733341] [10.3389/fgene.2023.1099272] |
12. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang. (2023) Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis. Molecular Medicine Reports, 27 (2): (1-11). [PMID:36601753] [10.3892/mmr.2023.12931] |
13. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu. (2022) Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis. PHARMACEUTICAL BIOLOGY, 60 (1): (909-914). [PMID:35575436] [10.1080/13880209.2022.2066139] |
14. Xiazhen Bao, Xuehui Cao, Yong Yuan, Bo Zhou, Congde Huo. (2021) A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid. SENSORS AND ACTUATORS B-CHEMICAL, 344 (130210). [PMID:] [10.1016/j.snb.2021.130210] |
15. Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu. (2021) Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway. FEBS Open Bio, 11 (8): (2118-2126). [PMID:34048148] [10.1002/2211-5463.13203] |
16. Zhu Yiming, Zhang Chihao, Huang Mingzhe, Lin Jiayun, Fan Xiao, Ni Tao. (2021) TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination. Frontiers in Cell and Developmental Biology, 9 [PMID:33869196] [10.3389/fcell.2021.644901] |