Grouped product items

SKU

Size

Availability

Price

Qty

E126853-5mg

5mg

In stock

$112.90

E126853-25mg

25mg

In stock

$399.90

E126853-100mg

100mg

In stock

$999.90

E126853-500mg

500mg

In stock

$3,499.90

Basic Description

Synonyms	2-(1-(4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one \| MFCD09837984 \| 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone \| 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-1-pipera
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Description:IC50 Value: 0.1 uM (VDAC-2) [1]Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers.V
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Note	Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc-. Application： Erastin has been used: as a positive control for inducing ferroptosis in hepatic stellate cell (HSC) to induce ferroptosis and in transferrin internalization assay of human fibrosarcoma HT1080 cells to induce ferroptosis of muscle-derived cell lines

Associated Targets(Human)

SLC7A11 Tchem Cystine/glutamate transporter (3 Activities)

Discover Target: SLC7A11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDAC2 Tchem Voltage-dependent anion-selective channel protein 2 (1 Activities)

Discover Target: VDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

A673 (619 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Calu-1 (518 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HL-60 (67320 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-1080 (3966 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-N-MC (815 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-937 (7138 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BJ (6930 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MIA PaCa-2 (5949 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HOS (906 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-ES1 (32 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LNCaP (8286 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver (3974 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VDAC2 Tchem Voltage-dependent anion-selective channel protein 2 (5 Activities)

Discover Target: VDAC2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC7A11 Tchem Cystine/glutamate transporter (150 Activities)

Discover Target: SLC7A11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAPK3 Tchem Mitogen-activated protein kinase; ERK1/ERK2 (651 Activities)

Discover Target: MAPK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-LMS-1 (121 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SW982 (212 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SJSA-1 (970 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SW872 (162 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

C-33-A (287 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SVR (53 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one
INCHI	InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
InChi Key	BKQFRNYHFIQEKN-UHFFFAOYSA-N
Canonical SMILES	CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl
Isomeric SMILES	CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl
WGK Germany	3
PubChem CID	11214940
Molecular Weight	547.04

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

16 results found

Lot Number	Certificate Type	Date	Item
L2205572	Certificate of Analysis	Sep 12, 2024	E126853
L2205573	Certificate of Analysis	Sep 12, 2024	E126853
G2430349	Certificate of Analysis	Jun 21, 2024	E126853
G2430350	Certificate of Analysis	Jun 21, 2024	E126853
G2430351	Certificate of Analysis	Jun 21, 2024	E126853
C2426003	Certificate of Analysis	Aug 10, 2023	E126853
H2328430	Certificate of Analysis	Aug 10, 2023	E126853
H2328431	Certificate of Analysis	Aug 10, 2023	E126853
H2328432	Certificate of Analysis	Aug 10, 2023	E126853
L2205441	Certificate of Analysis	Nov 22, 2022	E126853
L2205576	Certificate of Analysis	Nov 22, 2022	E126853
F2209101	Certificate of Analysis	May 19, 2022	E126853
F2209128	Certificate of Analysis	May 19, 2022	E126853
F2209175	Certificate of Analysis	May 19, 2022	E126853
F2209177	Certificate of Analysis	May 19, 2022	E126853
C2221030	Certificate of Analysis	Mar 24, 2022	E126853

Chemical and Physical Properties

Solubility	25°C: DMSO
Sensitivity	air ＆ heat sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3

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Categories: Technical articles

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Citations of This Product

1. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2023) TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID:]
2. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo. (2024) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease. JOURNAL OF ETHNOPHARMACOLOGY, 319 (23): (117196). [PMID:37717841]
3. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He. (2023) Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, (176009). [PMID:37619784]
4. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng. (2023) Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress. JOURNAL OF ETHNOPHARMACOLOGY, 316 (116729). [PMID:37277081]
5. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun. (2023) CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy. Acta Biomaterialia, 166 (604). [PMID:37156432]
6. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji. (2023) Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma. Frontiers in Genetics, 14 [PMID:36733341]
7. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang. (2023) Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis. Molecular Medicine Reports, 27 (2): (1-11). [PMID:36601753]
8. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu. (2022) Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis. PHARMACEUTICAL BIOLOGY, 60 (1): (909-914). [PMID:35575436]

References

1. Torii S et al.. (2016) An essential role for functional lysosomes in ferroptosis of cancer cells.. Biochem J, [PMID:26759376]
2. Chen L et al.. (2021) Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas.. Front Immunol, 12 (739039). [PMID:35185859]
3. Xie Y et al.. (2016) Ferroptosis: process and function.. Cell Death Differ, [PMID:26794443]
4. Simamura E et al.. (2008) Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents.. J Bioenerg Biomembr, 40 (3): (213-7). [PMID:18704666]
5. Haß C et al.. (2016) Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis.. Biochem Pharmacol, [PMID:26774450]
6. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2023) TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID:]
7. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo. (2024) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease. JOURNAL OF ETHNOPHARMACOLOGY, 319 (23): (117196). [PMID:37717841]
8. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He. (2023) Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, (176009). [PMID:37619784]
9. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng. (2023) Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress. JOURNAL OF ETHNOPHARMACOLOGY, 316 (116729). [PMID:37277081]
10. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun. (2023) CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy. Acta Biomaterialia, 166 (604). [PMID:37156432]
11. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji. (2023) Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma. Frontiers in Genetics, 14 [PMID:36733341]
12. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang. (2023) Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis. Molecular Medicine Reports, 27 (2): (1-11). [PMID:36601753]
13. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu. (2022) Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis. PHARMACEUTICAL BIOLOGY, 60 (1): (909-914). [PMID:35575436]

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Erastin - ≥99%, high purity , CAS No.571203-78-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

more

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

FAQs and Articles

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator