Erastin - 10mM in DMSO, high purity , CAS No.571203-78-6

  • 10mM in DMSO
Item Number
E424821
Grouped product items
SKUSizeAvailabilityPrice Qty
E424821-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$241.90

Selective ferrotopsis activator

Basic Description

SynonymsERASTIN | 571203-78-6 | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone | 2-(1-(4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one | MFCD09837984 | 2-[1-[4-[2-(4-chlorophenoxy)ac
Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsDescription:IC50 Value: 0.1 uM (VDAC-2) [1]Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers.V
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc-.

Associated Targets(Human)

SLC7A11 Tchem Cystine/glutamate transporter (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDAC2 Tchem Voltage-dependent anion-selective channel protein 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
A673 (619 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calu-1 (518 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-1080 (3966 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-N-MC (815 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-937 (7138 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BJ (6930 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOS (906 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-ES1 (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP (8286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver (3974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDAC2 Tchem Voltage-dependent anion-selective channel protein 2 (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC7A11 Tchem Cystine/glutamate transporter (150 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAPK3 Tchem Mitogen-activated protein kinase; ERK1/ERK2 (651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-LMS-1 (121 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW982 (212 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SJSA-1 (970 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW872 (162 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C-33-A (287 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SVR (53 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one
INCHI InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3
InChi Key BKQFRNYHFIQEKN-UHFFFAOYSA-N
Canonical SMILES CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl
Isomeric SMILES CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl
WGK Germany 3
PubChem CID 11214940
Molecular Weight 547.04

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

WGK Germany 3

Related Documents

Citations of This Product

1. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang.  (2023)  TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin.  JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,      [PMID:]
2. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo.  (2024)  Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease.  JOURNAL OF ETHNOPHARMACOLOGY,  319  (23): (117196).  [PMID:37717841]
3. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He.  (2023)  Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway.  EUROPEAN JOURNAL OF PHARMACOLOGY,    (176009).  [PMID:37619784]
4. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng.  (2023)  Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress.  JOURNAL OF ETHNOPHARMACOLOGY,  316  (116729).  [PMID:37277081]
5. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun.  (2023)  CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy.  Acta Biomaterialia,  166  (604).  [PMID:37156432]
6. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji.  (2023)  Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma.  Frontiers in Genetics,  14    [PMID:36733341]
7. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang.  (2023)  Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis.  Molecular Medicine Reports,  27  (2): (1-11).  [PMID:36601753]
8. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu.  (2022)  Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis.  PHARMACEUTICAL BIOLOGY,  60  (1): (909-914).  [PMID:35575436]
9. Xiazhen Bao, Xuehui Cao, Yong Yuan, Bo Zhou, Congde Huo.  (2021)  A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid.  SENSORS AND ACTUATORS B-CHEMICAL,  344  (130210).  [PMID:]
10. Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu.  (2021)  Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.  FEBS Open Bio,  11  (8): (2118-2126).  [PMID:34048148]
11. Zhu Yiming, Zhang Chihao, Huang Mingzhe, Lin Jiayun, Fan Xiao, Ni Tao.  (2021)  TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination.  Frontiers in Cell and Developmental Biology,    [PMID:33869196]

References

1. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang.  (2023)  TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin.  JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY,      [PMID:]
2. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo.  (2024)  Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease.  JOURNAL OF ETHNOPHARMACOLOGY,  319  (23): (117196).  [PMID:37717841]
3. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He.  (2023)  Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway.  EUROPEAN JOURNAL OF PHARMACOLOGY,    (176009).  [PMID:37619784]
4. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng.  (2023)  Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress.  JOURNAL OF ETHNOPHARMACOLOGY,  316  (116729).  [PMID:37277081]
5. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun.  (2023)  CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy.  Acta Biomaterialia,  166  (604).  [PMID:37156432]
6. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji.  (2023)  Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma.  Frontiers in Genetics,  14    [PMID:36733341]
7. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang.  (2023)  Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis.  Molecular Medicine Reports,  27  (2): (1-11).  [PMID:36601753]
8. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu.  (2022)  Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis.  PHARMACEUTICAL BIOLOGY,  60  (1): (909-914).  [PMID:35575436]
9. Xiazhen Bao, Xuehui Cao, Yong Yuan, Bo Zhou, Congde Huo.  (2021)  A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid.  SENSORS AND ACTUATORS B-CHEMICAL,  344  (130210).  [PMID:]
10. Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu.  (2021)  Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.  FEBS Open Bio,  11  (8): (2118-2126).  [PMID:34048148]
11. Zhu Yiming, Zhang Chihao, Huang Mingzhe, Lin Jiayun, Fan Xiao, Ni Tao.  (2021)  TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination.  Frontiers in Cell and Developmental Biology,    [PMID:33869196]

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