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Erastin - 10mM in DMSO, high purity , CAS No.571203-78-6 8 Citations
Selective ferrotopsis activator
Basic Description Synonyms ERASTIN | 571203-78-6 | 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone | 2-(1-(4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)ethyl)-3-(2-ethoxyphenyl)quinazolin-4(3H)-one | MFCD09837984 | 2-[1-[4-[2-(4-chlorophenoxy)ac Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Description:IC50 Value: 0.1 uM (VDAC-2) [1]Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers.V Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc-.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-[1-[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one INCHI InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3 InChi Key BKQFRNYHFIQEKN-UHFFFAOYSA-N Canonical SMILES CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl Isomeric SMILES CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl WGK Germany 3 PubChem CID 11214940 Molecular Weight 547.04
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
WGK Germany 3
Citations of This Product 1. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2023) TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID: 2. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo. (2024) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease. JOURNAL OF ETHNOPHARMACOLOGY, 319 (23): (117196). [PMID:37717841 ] 3. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He. (2023) Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, (176009). [PMID:37619784 ] 4. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng. (2023) Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress. JOURNAL OF ETHNOPHARMACOLOGY, 316 (116729). [PMID:37277081 ] 5. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun. (2023) CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy. Acta Biomaterialia, 166 (604). [PMID:37156432 ] 6. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji. (2023) Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma. Frontiers in Genetics, 14 [PMID:36733341 ] 7. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang. (2023) Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis. Molecular Medicine Reports, 27 (2): (1-11). [PMID:36601753 ] 8. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu. (2022) Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis. PHARMACEUTICAL BIOLOGY, 60 (1): (909-914). [PMID:35575436 ]
References 1. Junwei Liu, Meihong Zhang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2023) TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis inducer erastin. JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, [PMID: 2. Qiang-Ming Li, Tong Xu, Xue-Qiang Zha, Xiao-Wen Feng, Feng-Yun Zhang, Jian-Ping Luo. (2024) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease. JOURNAL OF ETHNOPHARMACOLOGY, 319 (23): (117196). [PMID:37717841 ] 3. Jiangbo Nie, Yuhang Ling, Mingchao Jin, Zhuo Chen, Wei Liu, Weiyun Shen, Tianshun Fang, Jianyou Li, Ying He. (2023) Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3/SLC7A11 pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, (176009). [PMID:37619784 ] 4. Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng. (2023) Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress. JOURNAL OF ETHNOPHARMACOLOGY, 316 (116729). [PMID:37277081 ] 5. Xinyu Zhang, Xueli Xu, Huimin Liu, Nengyi Ni, Shuangqing Liu, Yufang Gong, Guiqi Ma, Linlin Song, Qingwei Meng, Qing Fan, Xiao Sun. (2023) CCR2-overexpressing biomimetic carrier-free nanoplatform for enhanced cascade ferroptosis tumor therapy. Acta Biomaterialia, 166 (604). [PMID:37156432 ] 6. Huang Hui, Ye Zhifang, Li Zhengzhao, Wang Bo, Li Ke, Zhou Kai, Cao Huiyuan, Zheng Jiaxuan, Wang Guangji. (2023) Employing machine learning using ferroptosis-related genes to construct a prognosis model for patients with osteosarcoma. Frontiers in Genetics, 14 [PMID:36733341 ] 7. Jing Zhao, Mingming Ma, Lei Li, Gaoli Fang. (2023) Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis. Molecular Medicine Reports, 27 (2): (1-11). [PMID:36601753 ] 8. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu. (2022) Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis. PHARMACEUTICAL BIOLOGY, 60 (1): (909-914). [PMID:35575436 ]
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