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D120133-1mg

1mg

In stock

$129.90

D120133-5mg

5mg

In stock

$521.90

D120133-10mg

10mg

In stock

$937.90

Basic Description

Synonyms	AKOS024457904 \| 1,25-Dihydroxyvitamin D2 \| 1alpha,25-Dihydroxycalciferol \| NCGC00245115-01 \| ZGLHBRQAEXKACO-XJRQOBMKSA-N \| 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3,25-triol,(1a,3b,5Z,7E,22E)- \| 1.alpha.,25-dihydroxyvitamin d2 \| Ro 17-6218 \| 1,25-Dihydr
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a active metabolite of vitamin D2. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) exhibits equipotent antirachitic activity in rats as calcitriol. Ercalcitriol(1α,25-Dihydroxy Vita
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Product Description	Ercalcitriol (1α,25-Dihydroxy Vitamin D2)是维生素D2活性代谢物。

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
INCHI	InChI=1S/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25+,26+,28-/m1/s1
InChi Key	ZGLHBRQAEXKACO-XJRQOBMKSA-N
Canonical SMILES	CC(C=CC(C)C(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Isomeric SMILES	C[C@H](/C=C/[C@H](C)C(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
WGK Germany	3
PubChem CID	9547243
Molecular Weight	428.65
Beilstein	5635017

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
B2429008	Certificate of Analysis	Mar 23, 2022	D120133
E2225180	Certificate of Analysis	Mar 23, 2022	D120133
E2225188	Certificate of Analysis	Mar 23, 2022	D120133
E2225194	Certificate of Analysis	Mar 23, 2022	D120133
H2415062	Certificate of Analysis	Mar 23, 2022	D120133

Chemical and Physical Properties

Solubility	Soluble in ethanol;DMSO : ≥ 50 mg/mL (116.65 mM)
Sensitivity	light sensitive；

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H311:Toxic in contact with skin H330:Fatal if inhaled H372:Causes damage to organs through prolonged or repeated exposure H301+H311:Toxic if swallowed or in contact with skin
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
WGK Germany	3

References

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2. J L Finch,A S Dusso,T Pavlopoulos,E A Slatopolsky. (2001-06-26) Relative potencies of 1,25-(OH)(2)D(3) and 19-Nor-1,25-(OH)(2)D(2) on inducing differentiation and markers of bone formation in MG-63 cells.. Journal of the American Society of Nephrology : JASN, 12 ((7)): (1468-1474). [PMID:11423575]
3. Richard J Grostern,Paul J Bryar,Michele L Zimbric,Soesiawati R Darjatmoko,Boaz J Lissauer,Mary J Lindstrom,Janice M Lokken,Stephen A Strugnell,Daniel M Albert. (2002-05-25) Toxicity and dose-response studies of 1alpha-hydroxyvitamin D2 in a retinoblastoma xenograft model.. Archives of ophthalmology (Chicago, Ill. : 1960), 120 ((5)): (607-612). [PMID:12003610]
4. R A Henik,L J Forrest,A L Friedman. (2003-10-22) Rickets caused by excessive renal phosphate loss and apparent abnormal vitamin D metabolism in a cat.. Journal of the American Veterinary Medical Association, 215 ((11)): (1644-1649). [PMID:14567428]
5. Dengshun Miao,Bin He,Beate Lanske,Xiu-Ying Bai,Xin-Kang Tong,Geoffrey N Hendy,David Goltzman,Andrew C Karaplis. (2004-01-01) Skeletal abnormalities in Pth-null mice are influenced by dietary calcium.. Endocrinology, 145 ((4)): (2046-2053). [PMID:14701672]
6. Glendon M Zinser,JoEllen Welsh. (2004-06-05) Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice.. Molecular endocrinology (Baltimore, Md.), 18 ((9)): (2208-2223). [PMID:15178742]
7. Sonoko Masuda,Stephen A Strugnell,Joyce C Knutson,René St-Arnaud,Glenville Jones. (2006-03-07) Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2.. Biochimica et biophysica acta, 1761 ((2)): (221-234). [PMID:16516540]
8. Natasha Khazai,Suzanne E Judd,Vin Tangpricha. (2008-05-08) Calcium and vitamin D: skeletal and extraskeletal health.. Current rheumatology reports, 10 ((2)): (110-117). [PMID:18460265]
9. G S Hiremath,D Cettomai,M Baynes,J N Ratchford,S Newsome,D Harrison,D Kerr,B M Greenberg,P A Calabresi. (2009-04-23) Vitamin D status and effect of low-dose cholecalciferol and high-dose ergocalciferol supplementation in multiple sclerosis.. Multiple sclerosis (Houndmills, Basingstoke, England), 15 ((6)): (735-740). [PMID:19383644]
10. Jared P Reis,Denise von Mühlen,Erin D Michos,Edgar R Miller,Lawrence J Appel,Maria R Araneta,Elizabeth Barrett-Connor. (2009-06-23) Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis.. Atherosclerosis, 207 ((2)): (585-590). [PMID:19539290]
11. Klára Sochorová,Vít Budinský,Daniela Rozková,Zuzana Tobiasová,Sylvie Dusilová-Sulková,Radek Spísek,Jirina Bartůnková. (2009-08-08) Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells.. Clinical immunology (Orlando, Fla.), 133 ((1)): (69-77). [PMID:19660988]
12. Jim Bartley. (2010-12-08) Vitamin D: emerging roles in infection and immunity.. Expert review of anti-infective therapy, 8 ((12)): (1359-1369). [PMID:21133662]
13. Sirimas Sudsakorn,Abhishek Phatarphekar', "Thomas O'Shea", 'Hanlan Liu. (2010-12-21) Determination of 1,25-dihydroxyvitamin D2 in rat serum using liquid chromatography with tandem mass spectrometry.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879 ((2)): (139-145). [PMID:21168373]
14. Alexander Ströhle,Maike Wolters,Andreas Hahn. (2010-12-28) Micronutrients at the interface between inflammation and infection--ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid.. Inflammation & allergy drug targets, 10 ((1)): (54-63). [PMID:21184650]
15. Lilian Cuppari,Miriam Ghedini Garcia Lopes,Maria Ayako Kamimura. (2011-01-05) Vitamin D biology: from the discovery to its significance in chronic kidney disease.. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 21 ((1)): (113-116). [PMID:21195932]
16. Laura A G Armas,Robert P Heaney. (2011-01-18) Vitamin D: the iceberg nutrient.. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 21 ((2)): (134-139). [PMID:21239184]
17. Frederick G Strathmann,Thomas J Laha,Andrew N Hoofnagle. (2011-07-20) Quantification of 1α,25-dihydroxy vitamin D by immunoextraction and liquid chromatography-tandem mass spectrometry.. Clinical chemistry, 57 ((9)): (1279-1285). [PMID:21768219]
18. Hanna Baurska,Aleksandra Marchwicka,Anna Kłopot,Andrzej Kutner,Ewa Marcinkowska. (2012-07-04) Studies on the mechanisms of superagonistic pro-differentiating activities of side-chain modified analogs of vitamin D2.. Oncology reports, 28 ((3)): (1110-1116). [PMID:22751936]
19. Michelle R Denburg,Anne K Tsampalieros,Ian H de Boer,Justine Shults,Heidi J Kalkwarf,Babette S Zemel,Debbie Foerster,David Stokes,Mary B Leonard. (2013-04-03) Mineral metabolism and cortical volumetric bone mineral density in childhood chronic kidney disease.. The Journal of clinical endocrinology and metabolism, 98 ((5)): (1930-1938). [PMID:23547048]
20. G R Goodman,I R Dissanayake,A R Bowman,S Pun,Y Ma,W S Jee,H P Bryer,S Epstein. (2001-06-27) Transforming growth factor-beta administration modifies cyclosporine A-induced bone loss.. Bone, 28 ((6)): (583-588). [PMID:11425645]
21. D R Zimmerman,T A Reinhardt,R Kremer,D C Beitz,G S Reddy,R L Horst. (2001-07-27) Calcitroic acid is a major catabolic metabolite in the metabolism of 1 alpha-dihydroxyvitamin D(2).. Archives of biochemistry and biophysics, 392 ((1)): (14-22). [PMID:11469789]
22. Michał Chodyński,Joanna Wietrzyk,Ewa Marcinkowska,Adam Opolski,Wiesław Szelejewski,Andrzej Kutner. (2002-07-19) Synthesis and antiproliferative activity of side-chain unsaturated and homologated analogs of 1,25-dihydroxyvitamin D(2). (24E)-(1S)-24-Dehydro-24a-homo-1,25-dihydroxyergocalciferol and congeners.. Steroids, 67 ((9)): (789-798). [PMID:12123791]
23. R L Horst,J A Omdahl,S Reddy. (2003-01-10) Rat cytochrome P450C24 (CYP24) does not metabolize 1,25-dihydroxyvitamin D2 to calcitroic acid.. Journal of cellular biochemistry, 88 ((2)): (282-285). [PMID:12520527]
24. Qing Wang,Xuening Wang,George P Studzinski. (2003-08-05) Jun N-terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25-dihydroxyvitamin D3.. Journal of cellular biochemistry, 89 ((6)): (1087-1101). [PMID:12898508]
25. Ryo Okazaki. (2005-01-22) [Vitamin D metabolites].. Nihon rinsho. Japanese journal of clinical medicine, 62 Suppl 12 (167-170). [PMID:15658291]
26. Shigeaki Kato,Mi-sun Kim,Kazuyoshi Yamaoka,Ryoji Fujiki. (2007-06-15) Mechanisms of transcriptional repression by 1,25(OH)2 vitamin D.. Current opinion in nephrology and hypertension, 16 ((4)): (297-304). [PMID:17565270]
27. Joanna Wietrzyk,Dmitry Nevozhay,Magdalena Milczarek,Beata Filip,Andrzej Kutner. (2008-01-12) Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model.. Cancer chemotherapy and pharmacology, 62 ((5)): (787-797). [PMID:18188568]
28. Joanna Wietrzyk,Magdalena Milczarek,Andrzej Kutner. (2008-03-01) The effect of combined treatment on head and neck human cancer cell lines with novel analogs of calcitriol and cytostatics.. Oncology research, 16 ((11)): (517-525). [PMID:18306931]
29. Ogo Egbuna,Steven Quinn,Lakshmi Kantham,Robert Butters,Jiang Pang,Martin Pollak,David Goltzman,Edward Brown. (2009-05-29) The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone.. American journal of physiology. Renal physiology, 297 ((3)): (F720-F728). [PMID:19474191]
30. Yuki Nagata,Yasuo Imanishi,Akira Ishii,Masafumi Kurajoh,Koka Motoyama,Tomoaki Morioka,Hiroshi Naka,Katsuhito Mori,Takami Miki,Masanori Emoto,Masaaki Inaba. (2011-08-09) Evaluation of bone markers in hypophosphatemic rickets/osteomalacia.. Endocrine, 40 ((2)): (315-317). [PMID:21822687]
31. Rachael M Biancuzzo,Nigel Clarke,Richard E Reitz,Thomas G Travison,Michael F Holick. (2013-02-07) Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation.. The Journal of clinical endocrinology and metabolism, 98 ((3)): (973-979). [PMID:23386645]

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Ercalcitriol - 97%, high purity , CAS No.60133-18-8

Basic Description

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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