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Erenumab (anti-CALCRL) (Ab170518) - SEC
The purity of Erenumab (anti-CALCRL) (Ab170518) is more than 95% verified by HPLC.
SKU | Size | Availability | Price | Qty |
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Ab170518-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 | |
Ab170518-1mg | 1mg | In stock | $237.90 | |
Ab170518-5mg | 5mg | In stock | $657.90 | |
Ab170518-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,047.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2Sa; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Product Name | Erenumab (anti-CALCRL), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to CALCRL, >95%, high purity, Human IgG2SA |
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Synonyms | Calcitonin receptor-like receptor | CGRP type 1 receptor |
Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
Host species | Human |
Specificity | CALCRL |
Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
Conjugation | Unconjugated |
Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
Action Type | ANTAGONIST |
Mechanism of action | Antibody of CGRP receptor |
Product Description | Erenumab is a fully human monoclonal antibody. Erenumab inhibits the calcitonin gene–related peptide (CGRP) receptor. Erenumab can be used for the prevention of episodic migraine. |
Antibody Type | Primary antibody |
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Clonality | Recombinant |
Isotype | Human IgG2SA |
Light Chain Type | lambda |
SDS-PAGE | 27.7 kDa (Light Chain) & 52.0 kDa (Heavy Chain), under reducing conditions; 175.2 kDa, under non-reducing conditions. |
Purification Method | Protein A purified |
Purity | >95% |
Source | CHO supernatant |
Form | Liquid |
Concentration | Lot by Lot |
Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
CAS | 1582205-90-0 |
Erenumab (anti-CALCRL) (Ab170518) - SEC
The purity of Erenumab (anti-CALCRL) (Ab170518) is more than 95% verified by HPLC.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IMGT/mAb-DB | 618 |
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Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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ZJ24F0102480 | Certificate of Analysis | Jan 18, 2024 | Ab170518 |
ZJ24F0102479 | Certificate of Analysis | Jan 18, 2024 | Ab170518 |
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3. Shi L, Lehto SG, Zhu DX, Sun H, Zhang J, Smith BP, Immke DC, Wild KD, Xu C. (2016) Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor.. J Pharmacol Exp Ther, 356 (1): (223-31). [PMID:26559125] [10.1021/op500134e] |
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17. Hong Y, Hay DL, Quirion R, Poyner DR. (2012) The pharmacology of adrenomedullin 2/intermedin.. Br J Pharmacol, 166 (1): (110-20). [PMID:21658025] [10.1021/op500134e] |
18. Liu H, Altenbach RJ, Carr TL, Chandran P, Hsieh GC, Lewis LG, Manelli AM, Milicic I, Marsh KC, Miller TR et al.. (2008) cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.. J Med Chem, 51 (22): (7094-8). [PMID:18983139] [10.1021/op500134e] |
19. Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Okuda K, Sakamoto K, Shirouzu M, Shindo T, Yokoyama S. (2012) Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.. Protein Sci, 21 (2): (199-210). [PMID:22102369] [10.1021/op500134e] |
20. Joshi P, Anderson C, Binch H, Hadida S, Yoo S, Bergeron D, Decker C, terHaar E, Moore J, Garcia-Guzman M et al.. (2014) Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists.. Bioorg Med Chem Lett, 24 (3): (845-9). [PMID:24405707] [10.1021/op500134e] |
21. Hay DL, Garelja ML, Poyner DR, Walker CS. (2018) Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25.. Br J Pharmacol, 175 (1): (3-17). [PMID:29059473] [10.1021/op500134e] |
22. Luo G, Chen L, Conway CM, Denton R, Keavy D, Signor L, Kostich W, Lentz KA, Santone KS, Schartman R et al.. (2012) Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine.. J Med Chem, 55 (23): (10644-51). [PMID:23153230] [10.1021/op500134e] |
23. Bucknell SJ, Ator MA, Brown AJH, Brown J, Cansfield AD, Cansfield JE, Christopher JA, Congreve M, Cseke G, Deflorian F et al.. (2020) Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.. J Med Chem, 63 (14): (7906-7920). [PMID:32558564] [10.1021/op500134e] |
24. Mercer SE, Chaturvedula PV, Conway CM, Cook DA, Davis CD, Pin SS, Macci R, Schartman R, Signor LJ, Widmann KA et al.. (2021) Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.. Bioorg Med Chem Lett, 31 (13): (127624). [PMID:33096162] [10.1021/op500134e] |
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26. Pan KS, Siow A, Hay DL, Walker CS. (2020) Antagonism of CGRP Signaling by Rimegepant at Two Receptors.. Front Pharmacol, 11 (13): (1240). [PMID:32973499] [10.1021/op500134e] |
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44. Dubowchik GM, Conway CM, Xin AW.. (2020) Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success.. J Med Chem, 63 (13): (6600-6623). [PMID:32058712] [10.1021/acs.jmedchem.9b01810] |
45. Flühmann, B B, Muff, R R, Hunziker, W W, Fischer, J A JA and Born, W W.. (1995) A human orphan calcitonin receptor-like structure.. Biochemical and biophysical research communications, (5): [PMID:7818539] |
46. Chan, K Y KY and 11 more authors.. (2010) Characterization of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) in human isolated coronary arteries.. The Journal of pharmacology and experimental therapeutics, (1): [PMID:20573757] |
47. Walker, Christopher S CS, Raddant, Ann C AC, Woolley, Michael J MJ, Russo, Andrew F AF and Hay, Debbie L DL.. (2018) CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured.. Cephalalgia : an international journal of headache, [PMID:28165287] |
48. Mackie, Duncan I DI and 11 more authors.. (2018) hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.. The Journal of experimental medicine, (3): [PMID:30115739] |
49. Negro, Andrea A and Martelletti, Paolo P.. (2019) Gepants for the treatment of migraine.. Expert opinion on investigational drugs, [PMID:31081399] |