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Erlotinib - ≥98%, high purity , CAS No.183321-74-6, Inhibitor of epidermal growth factor receptor;Inhibitor of OATP2B1
Basic Description Synonyms Erlotinib|183321-74-6|N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine|Tarceva|Erlotinib free base|4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline|4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-|OSI-774|erloti Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Erlotinib hydrochloride (trade name Tarceva;NSC 718781; OSI 744; R 1415 ) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. Erlotinib hydrochloride (trade name Tarceva;NSC 718781; OSI
Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of epidermal growth factor receptor;Inhibitor of OATP2B1 Product Description Erlotinib, Free Base, is the free base form of erlotinib hydrochloride (sc-202154), a small molecule EGFR/HER-1 (human epidermal growth factor receptor) tyrosine kinase reversible inhibitor.
Names and Identifiers IUPAC Name N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine INCHI InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) InChi Key AAKJLRGGTJKAMG-UHFFFAOYSA-N Canonical SMILES COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC Isomeric SMILES COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC Alternate CAS 183321-74-6 PubChem CID 176870 MeSH Entry Terms 11C erlotinib;11C-erlotinib;358,774, CP;358774, CP;CP 358,774;CP 358774;CP-358,774;CP-358774;CP358,774;CP358774;erlotinib;erlotinib HCl;erlotinib hydrochloride;HCl, Erlotinib;Hydrochloride, Erlotinib;N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin- Molecular Weight 393.44
Chemical and Physical Properties Solubility DMSO Refractive Index 1.62 Melt Point(°C) 167-180°C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 , GHS07 Signal Warning Hazard Statements H351: Suspected of causing cancer
H411: Toxic to aquatic life with long lasting effects
H413: May cause long lasting harmful effects to aquatic life
H302: Harmful if swallowed
Precautionary Statements P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
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