Grouped product items

SKU

Size

Availability

Price

Qty

E129310-100mg

100mg

Available within 4-8 weeks(?)

$64.90

E129310-500mg

500mg

Available within 4-8 weeks(?)

$97.90

E129310-1g

Available within 4-8 weeks(?)

$176.90

E129310-5g

Available within 4-8 weeks(?)

$793.90

E129310-25g

25g

Available within 4-8 weeks(?)

$3,572.90

E129310-100g

100g

Available within 4-8 weeks(?)

$12,859.90

Basic Description

Synonyms	HCl, Erlotinib \| KS-1202 \| CP-358,774-01 \| ERLOTINIB HYDROCHLORIDE [MI] \| N-(3-ETHENYLPHENYL)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMINE HYDROCHLORIDE \| Tarceva (Erlotinib Hydrochloride) \| GTTBEUCJPZQMDZ-UHFFFAOYSA-N \| CHEBI:53509 \| ERLOTINIB HYDROCHLORID
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Erlotinib hydrochloride is an inhibitor of the receptor tyrosine kinase EGFR (epidermal growth factor receptor). It is used clinically for the treatment of non-small cell lung cancer (NSCLC) and in combination for metastatic pancreatic cancer.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Epidermal growth factor receptor erbB1 inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product Description Erlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM. Product Application Erlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line.

Associated Targets(Human)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 (0 Activities)

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EGFR Tclin Epidermal growth factor receptor (1 Activities)

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BRAF Tclin Serine/threonine-protein kinase B-raf (0 Activities)

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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

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ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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HT-29 (80576 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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OVCAR-4 (44535 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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SF-295 (48000 Activities)

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SK-LU-1 (435 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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U-251 (51189 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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NCI-H322M (45589 Activities)

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HCT-116 (91556 Activities)

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HOP-92 (41141 Activities)

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Hs-578T (29457 Activities)

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HepG2 (196354 Activities)

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NCI-H460 (60772 Activities)

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IGROV-1 (47897 Activities)

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KB (17409 Activities)

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LOX IMVI (44321 Activities)

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HOP-62 (47048 Activities)

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MDA-MB-435 (38290 Activities)

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MDA-N (28205 Activities)

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MDA-MB-231 (73002 Activities)

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SNB-75 (44215 Activities)

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NCI-H23 (49055 Activities)

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SF-539 (44845 Activities)

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SW-620 (52400 Activities)

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HCT-15 (51914 Activities)

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BRAF Tclin Serine/threonine-protein kinase B-raf (11587 Activities)

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Associated Targets(non-human)

Mus musculus (284745 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Brain (1 Activities)

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Plasma (328 Activities)

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine;hydrochloride
INCHI	InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChi Key	GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Canonical SMILES	COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
Isomeric SMILES	COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl
Alternate CAS	183319-69-9
PubChem CID	176871
NSC Number	718781
MeSH Entry Terms	11C erlotinib;11C-erlotinib;358,774, CP;358774, CP;CP 358,774;CP 358774;CP-358,774;CP-358774;CP358,774;CP358774;erlotinib;erlotinib HCl;erlotinib hydrochloride;HCl, Erlotinib;Hydrochloride, Erlotinib;N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-
Molecular Weight	429.9

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
F2229215	Certificate of Analysis	Apr 03, 2024	E129310
F2229349	Certificate of Analysis	Apr 03, 2024	E129310
F2229350	Certificate of Analysis	Apr 03, 2024	E129310
F2229353	Certificate of Analysis	Apr 03, 2024	E129310
D2126194	Certificate of Analysis	Feb 09, 2023	E129310
D2126195	Certificate of Analysis	Feb 09, 2023	E129310

Chemical and Physical Properties

Solubility	Soluble in DMSO (3 mg/ml), methanol (sparingly), water (<1 mg/ml), and ethanol (<1 mg/ml).
Sensitivity	Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS09, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H351:Suspected of causing cancer H373:Causes damage to organs through prolonged or repeated exposure H411:Toxic to aquatic life with long lasting effects H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed H317:May cause an allergic skin reaction H332:Harmful if inhaled H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child H302+H332:Harmful if swallowed or if inhaled H362:May cause harm to breast-fed children
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Citations of This Product

1. Yun Zheng, Qiong Zhao, Jing Lin, Xiaoyang Dai, Chenyu Zhu, Yujie Wang, Hongye Fu. (2023) Xijiao Dihuang decoction relieves the erlotinib-induced dermatitis. EXPERIMENTAL CELL RESEARCH, 423 (113437). [PMID:36435221]

References

1. Stahlhut C & Slack FJ. (2015) Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation.. Cell Cycle, 14 (13): (2171-80). [PMID:25714397]
2. Vu TH et al.. (2015) Depsides: lichen metabolites active against hepatitis C virus.. PLoS One, 10 (3): (e0120405). [PMID:25793970]
3. Nishimura T et al.. (2015) Effect of the molecular targeted drug, erlotinib, against endometrial cancer expressing high levels of epidermal growth factor receptor.. BMC Cancer, 15 (957). [PMID:26673416]
4. Gan CJ et al.. (2020) EGF receptor inhibitors comprehensively suppress hepatitis B virus by downregulation of STAT3 phosphorylation.. Biochem Biophys Rep, 22 (100763). [PMID:32322693]
5. Yun Zheng, Qiong Zhao, Jing Lin, Xiaoyang Dai, Chenyu Zhu, Yujie Wang, Hongye Fu. (2023) Xijiao Dihuang decoction relieves the erlotinib-induced dermatitis. EXPERIMENTAL CELL RESEARCH, 423 (113437). [PMID:36435221]

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Erlotinib HCl (OSI-744) - ≥99%, high purity , Epidermal growth factor receptor erbB1 inhibitor, CAS No.183319-69-9, Epidermal growth factor receptor erbB1 inhibitor

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
E129310-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$64.90
E129310-500mg	500mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$97.90
E129310-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$176.90
E129310-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$793.90
E129310-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$3,572.90
E129310-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$12,859.90