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Ervogastat - 98%, high purity , CAS No.2186700-33-2, Inhibitor of diacylglycerol O-acyltransferase 2

Item Number
E413691
Grouped product items
SKUSizeAvailabilityPrice Qty
E413691-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$319.90
E413691-10mg
10mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$449.90
E413691-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$778.90
E413691-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,089.90
E413691-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,519.90
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diacylglycerol O-acyltransferase 2 Inhibitor

Basic Description

Synonyms(S)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-(tetrahydrofuran-3-yl)pyrimidine-5-carboxamide | BSOIY5AKQW | US10071992, Example 3.4 | AKOS040759712 | US10071992, Example 1 | 2-(5-((3-Ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-((3S)-oxolan3-yl)pyrimidine
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsErvogastat (PF-06865571) is a potent diacylglycerol acyltransferase 2 inhibitor (DGAT2i) that reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of diacylglycerol O-acyltransferase 2
Product Description

Information

Ervogastat (PF-06865571) is a potent diacylglycerol acyltransferase 2 inhibitor (DGAT2i) that reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).

Associated Targets(Human)

DGAT2 Tchem Diacylglycerol O-acyltransferase 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C8 Tchem Cytochrome P450 2C8 (1492 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2B6 Tchem Cytochrome P450 2B6 (1338 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DGAT2 Tchem Diacylglycerol O-acyltransferase 2 (347 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DGAT1 Tclin Diacylglycerol O-acyltransferase 1 (1719 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4/3A5 (100 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MGAT2 Tchem Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (703 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MGAT3 Tchem Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MGAT1 Tchem Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-[5-(3-ethoxypyridin-2-yl)oxypyridin-3-yl]-N-[(3S)-oxolan-3-yl]pyrimidine-5-carboxamide
INCHI InChI=1S/C21H21N5O4/c1-2-29-18-4-3-6-23-21(18)30-17-8-14(9-22-12-17)19-24-10-15(11-25-19)20(27)26-16-5-7-28-13-16/h3-4,6,8-12,16H,2,5,7,13H2,1H3,(H,26,27)/t16-/m0/s1
InChi Key UKBQFBRPXKGJPY-INIZCTEOSA-N
Canonical SMILES CCOC1=C(N=CC=C1)OC2=CN=CC(=C2)C3=NC=C(C=N3)C(=O)NC4CCOC4
Isomeric SMILES CCOC1=C(N=CC=C1)OC2=CN=CC(=C2)C3=NC=C(C=N3)C(=O)N[C@H]4CCOC4
PubChem CID 134262752
Molecular Weight 407.42

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO : 81 mg/mL；Ethanol : 5 mg/mL；Water : Insoluble

Related Documents

 SDS

 Specification Sheet

References

1. Futatsugi K, Cabral S, Kung DW, Huard K, Lee E, Boehm M, Bauman J, Clark RW, Coffey SB, Crowley C et al..  (2022)  Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis..  J Med Chem,  71  (13): (1755-70).  [PMID:36322383] [10.1021/acs.jmedchem.2c01200]

Solution Calculators

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