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ERW1041E , CAS No.E610184, Inhibitor of transglutaminase 2

Item Number
E610184
Grouped product items
SKUSizeAvailabilityPrice Qty
E610184-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$600.90
E610184-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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transglutaminase 2 Inhibitor

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of transglutaminase 2

Associated Targets(Human)

TGM2 Tchem Protein-glutamine gamma-glutamyltransferase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TGM3 Tchem Protein-glutamine glutamyltransferase E (94 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TGM1 Tchem Protein-glutamine gamma-glutamyltransferase K (164 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TGM2 Tchem Protein-glutamine gamma-glutamyltransferase (1221 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F13A1 Tchem Coagulation factor XIII (223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TXN Tchem Thioredoxin (111 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tgm2 Protein-glutamine gamma-glutamyltransferase 2 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name quinolin-3-ylmethyl (2S)-2-[[(5S)-3-bromo-4,5-dihydro-1,2-oxazol-5-yl]methylcarbamoyl]pyrrolidine-1-carboxylate
INCHI InChI=1S/C20H21BrN4O4/c21-18-9-15(29-24-18)11-23-19(26)17-6-3-7-25(17)20(27)28-12-13-8-14-4-1-2-5-16(14)22-10-13/h1-2,4-5,8,10,15,17H,3,6-7,9,11-12H2,(H,23,26)/t15-,17-/m0/s1
InChi Key FDWIPZHANLQVMF-RDJZCZTQSA-N
Canonical SMILES O=C([C@@H]1CCCN1C(=O)OCc1cnc2c(c1)cccc2)NC[C@H]1ON=C(C1)Br
Isomeric SMILES C1C[C@H](N(C1)C(=O)OCC2=CC3=CC=CC=C3N=C2)C(=O)NC[C@@H]4CC(=NO4)Br
PubChem CID 16094751

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Watts RE, Siegel M, Khosla C.  (2006)  Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles..  J Med Chem,  49  (25): (7493-501).  [PMID:17149878]
2. Dafik L, Albertelli M, Stamnaes J, Sollid LM, Khosla C.  (2012)  Activation and inhibition of transglutaminase 2 in mice..  PLoS ONE,  7  (2): (e30642).  [PMID:22319575]
3. Chrobok NL, Bol JGJM, Jongenelen CA, Brevé JJP, El Alaoui S, Wilhelmus MMM, Drukarch B, van Dam AM.  (2018)  Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis..  PLoS ONE,  13  (4): (e0196433).  [PMID:29689097]

Solution Calculators

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