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Escin - 95%, high purity , CAS No.6805-41-0

3 Citations

≥95%

CAS#: 6805-41-0
Formula: C₅₅H₈₆O₂₄
Molecular Weight: 1131.26
EC Number: 229-880-6
MDL number: MFCD00076054
PubChem CID: 16211024
PubChem SID: 488199073

Item Number

E121095

Grouped product items
SKU	Size	Availability	Price
E121095-200mg	200mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$15.90
E121095-250mg	250mg	In stock	$17.90
E121095-1g	1g	In stock	$52.90
E121095-5g	5g	In stock	$197.90
E121095-25g	25g	In stock	$889.90

Basic Description

Synonyms	Aescin, 98% \| AS-15594 \| BDBM80094 \| MLS002695979 \| (2S,3S,4S,5R,6R)-6-[[(4S,6aR,6bS,8R,8aR,9R,10R,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetrade
Specifications & Purity	≥95%
Shipped In	Normal
Product Description	Product Application: Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut seeds, is used and studied as a vasoprotective anti-inflammatory, anti-edematous and antinociceptive agent.

Associated Targets(Human)

CCR6 Tchem C-C chemokine receptor type 6 (388 Activities)

Discover Target: CCR6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Aplnr Apelin receptor (201 Activities)

Discover Target: Aplnr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488199073
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488199073
IUPAC Name	(2S,3S,4S,5R,6R)-6-[[(4S,6bS,8R,9R)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid
INCHI	InChI=1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10+/t26?,27-,28-,29?,30?,31-,32?,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43?,44+,47+,48-,49-,51?,52-,53?,54-,55?/m1/s1
InChi Key	AXNVHPCVMSNXNP-YSYFQUGBSA-N
Canonical SMILES	CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C
Isomeric SMILES	C/C=C(\C)/C(=O)OC1[C@@H](C2([C@@H](C[C@@]3(C(=CCC4C3(CCC5C4(CCC([C@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)O)O[C@@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)C)C)C2CC1(C)C)C)O)CO)OC(=O)C
WGK Germany	2
RTECS	KF6296000
PubChem CID	16211024
Molecular Weight	1131.26

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
K1821135	Certificate of Analysis	Sep 19, 2022	E121095
K1821134	Certificate of Analysis	Sep 19, 2022	E121095
C2331301	Certificate of Analysis	Jul 27, 2022	E121095
C2331302	Certificate of Analysis	Jul 27, 2022	E121095
C2331303	Certificate of Analysis	Jul 27, 2022	E121095
C2331304	Certificate of Analysis	Jul 27, 2022	E121095
C2331309	Certificate of Analysis	Jul 27, 2022	E121095
C2331313	Certificate of Analysis	Jul 27, 2022	E121095
C2331325	Certificate of Analysis	Jul 27, 2022	E121095
C2331334	Certificate of Analysis	Jul 27, 2022	E121095
I1424078	Certificate of Analysis	Jul 18, 2022	E121095

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Chemical and Physical Properties

Solubility	Soluble in methanol.

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation H335:May cause respiratory irritation H411:Toxic to aquatic life with long lasting effects H302:Harmful if swallowed H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	KF6296000

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Da Wang, Luping Sha, Chen Xu, Ying Huang, Chengcheng Tang, Tingting Xu, Xianzhe Li, Donghua Di, Jie Liu, Li Yang. (2022) Natural saponin and cholesterol assembled nanostructures as the promising delivery method for saponin. COLLOIDS AND SURFACES B-BIOINTERFACES, 214 (112448). [PMID:35306344] [10.1016/j.colsurfb.2022.112448]
2. Shengyun Li, Yaowu Yuan, Chenchen Yu, Hao Gao, Jianxin Tan, Yiling Tian. (2020) Establishment and Application of a Method for the Determination of Ganoderic Acid A. JOURNAL OF FOOD QUALITY, 2020 (6621853). [PMID:] [10.1155/2020/6621853]
3. Minyu Zhu, Jinwei Ying, Chaowei Lin, Yu Wang, Kelun Huang, Yang Zhou, Honglin Teng. (2018) β-Escin inhibits the proliferation of osteosarcoma cells via blocking the PI3K/Akt pathway. RSC Advances, 8 (52): (29637-29644). [PMID:35547316] [10.1039/C8RA03578D]

References

1. D Panigati. (1992-07-01) [Pharmacology of escin, a saponin of Aesculus hippocastanum L. II. Pharmacodynamics of escin. Chapter II].. Bollettino chimico farmaceutico, 131 ((7)): (284-293). [PMID:1476699]
2. D Panigati. (1992-06-01) [Pharmacology of escin, a saponin from Aesculus hyppocastanum L. II. Pharmacodynamics of escin. Chapter I].. Bollettino chimico farmaceutico, 131 ((6)): (242-246). [PMID:1445691]
3. D Panigati. (1992-09-01) [The pharmacology of escin, a saponin of Aesculus hippocastanum L. III. Pharmacokinetics and toxicology].. Bollettino chimico farmaceutico, 131 ((8)): (320-321). [PMID:1492967]
4. J S Fan,P Palade. (1998-11-03) Perforated patch recording with beta-escin.. Pflugers Archiv : European journal of physiology, 436 ((6)): (1021-1023). [PMID:9799421]
5. Kuzhuvelil B Harikumar,Bokyung Sung,Manoj K Pandey,Sushovan Guha,Sunil Krishnan,Bharat B Aggarwal. (2010-01-28) Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.. Molecular pharmacology, 77 ((5)): (818-827). [PMID:20103608]
6. Zhenzhen Zhang,Jian Gao,Xueting Cai,Youlong Zhao,Yafei Wang,Wuguang Lu,Zhenhua Gu,Shuangquan Zhang,Peng Cao. (2011-04-01) Escin sodium induces apoptosis of human acute leukemia Jurkat T cells.. Phytotherapy research : PTR, 25 ((12)): (1747-1755). [PMID:21452372]
7. Yan-Lei Wang,You-Ling Jing,Qing-Yan Cai,Guo-Jin Cui,Yi-Bing Zhang,Yan-Wei Wang. (2011-05-13) [Effects of sodium aescinate on lipid peroxidiation injury induced by intestinal ischemia/reperfusion].. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 27 ((1)): (17-18). [PMID:21560331]
8. Ellen De Geyter,Guy Smagghe,Yvan Rahbé,Danny Geelen. (2011-07-01) Triterpene saponins of Quillaja saponaria show strong aphicidal and deterrent activity against the pea aphid Acyrthosiphon pisum.. Pest management science, 68 ((2)): (164-169). [PMID:21717567]
9. Na Jiang,Wenyu Xin,Tian Wang,Leiming Zhang,Huaying Fan,Yuan Du,Chong Li,Fenghua Fu. (2011-08-02) Protective effect of aescin from the seeds of Aesculus hippocastanum on liver injury induced by endotoxin in mice.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 18 ((14)): (1276-1284). [PMID:21802269]
10. G Cravotto,L Beltramo,S Sapino,A Binello,M E Carlotti. (2011-08-02) A new cyclodextrin-grafted viscose loaded with aescin formulations for a cosmeto-textile approach to chronic venous insufficiency.. Journal of materials science. Materials in medicine, 22 ((10)): (2387-2395). [PMID:21805331]
11. Caroline Morin,Samuel Fortin,Eric Rousseau. (2011-08-09) 19,20-EpDPE, a bioactive CYP450 metabolite of DHA monoacyglyceride, decreases Ca²⁺ sensitivity in human pulmonary arteries.. American journal of physiology. Heart and circulatory physiology, 301 ((4)): (H1311-H1318). [PMID:21821782]
12. H Van de Ven,M Vermeersch,A Matheeussen,J Vandervoort,W Weyenberg,S Apers,P Cos,L Maes,A Ludwig. (2011-08-26) PLGA nanoparticles loaded with the antileishmanial saponin β-aescin: factor influence study and in vitro efficacy evaluation.. International journal of pharmaceutics, 420 ((1)): (122-132). [PMID:21864661]
13. Florian Herrmann,Michael Wink. (2011-10-05) Synergistic interactions of saponins and monoterpenes in HeLa cells, Cos7 cells and in erythrocytes.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 18 ((13)): (1191-1196). [PMID:21968386]
14. H Van de Ven,M Vermeersch,R E Vandenbroucke,A Matheeussen,S Apers,W Weyenberg,S C De Smedt,P Cos,L Maes,A Ludwig. (2011-11-15) Intracellular drug delivery in Leishmania-infected macrophages: Evaluation of saponin-loaded PLGA nanoparticles.. Journal of drug targeting, 20 ((2)): (142-154). [PMID:22080813]
15. Tian Wei,Wang Tong,Sun Wen-ping,Deng Xiao-hui,Xue Qiang,Li Tian-shui,Chen Zhi-fang,Jin Hong-fang,Ni Li,Zhao Bin,Du Jun-bao,Ge Bao-ming. (2011-11-18) The impact of sodium aescinate on acute lung injury induced by oleic acid in rats.. Experimental lung research, 37 ((10)): (585-599). [PMID:22087513]
16. R Luzzi,B Feragalli,G Belcaro,M R Cesarone,U Cornelli,M Dugall,M Hosoi. (2011-12-14) Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy.. Panminerva medica, 53 ((3 Suppl 1)): (51-55). [PMID:22108477]
17. Yong-Wei Wang,Shuang-Jia Wang,Yi-Nan Zhou,Shang-Ha Pan,Bei Sun. (2012-01-25) Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo.. Journal of cancer research and clinical oncology, 138 ((5)): (785-797). [PMID:22270965]
18. Hua Wang,Tao Li,Ming Lei,Miao-ling Li,Yin-yuan Ding,Yan Yang,Xiao-rong Zeng. (2012-08-07) [Application of recording SK2 current in human atrial myocytes by perforated patch clamp techniques with the mix of beta-escin and amphotericin B].. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 28 ((3)): (214-218). [PMID:22860418]
19. Shutai Liu,Huaizhou Wang,Caiqing Qiu,Jing Zhang,Taowen Zhang,Wenjuan Zhou,Zhishan Lu,Xiaohui Rausch-Fan,Zhonghao Liu. (2012-08-17) Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells.. Molecular medicine reports, 6 ((5)): (1150-1154). [PMID:22895831]
20. Takashi Takano,Takeharu Kaneda,Masaki Kaneshige,Tomoko Tsutsumi,Yoshitsugu Ochiai,Kazumasa Shimizu,Ryo Hondo,Mariko Mochizuki,Fukiko Ueda. (2012-12-15) Interaction between titanium and cadmium in various guinea pig organs.. Biological trace element research, 151 ((2)): (209-216). [PMID:23238609]
21. D Certan,V Righini,M Oliva,P Fioravanti,M Bevilacqua. (2013-05-15) Bioavailability of l-thyroxine and its metabolites after topical treatment with an emulsion containing 0.1% micronised l-thyroxine.. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 148 ((3)): (287-292). [PMID:23670065]
22. Hany K M Dweck,John R Carlson. (2019-12-17) Molecular Logic and Evolution of Bitter Taste in Drosophila.. Current biology : CB, 30 ((1)): (17-30). [PMID:31839451]
23. R W Frick. (2000-04-01) Three treatments for chronic venous insufficiency: escin, hydroxyethylrutoside, and Daflon.. Angiology, 51 ((3)): (197-205). [PMID:10744007]
24. Wenyu Xin,Leiming Zhang,Fang Sun,Na Jiang,Huaying Fan,Tian Wang,Zhen Li,Jie He,Fenghua Fu. (2010-09-21) Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 18 ((4)): (272-277). [PMID:20850956]
25. Leiming Zhang,Hongsheng Wang,Huaying Fan,Tian Wang,Na Jiang,Pengfei Yu,Fenghua Fu. (2011-05-21) The potent anti-inflammatory agent escin does not increase corticosterone secretion and immune cell apoptosis in mice.. Fitoterapia, 82 ((6)): (861-867). [PMID:21596110]
26. Lyndsay J Clelland,Brendan M Browne,Silvina M Alvarez,Amy S Miner,Paul H Ratz. (2011-06-28) Rho-kinase inhibition attenuates calcium-induced contraction in β-escin but not Triton X-100 permeabilized rabbit femoral artery.. Journal of muscle research and cell motility, 32 ((2)): (77-88). [PMID:21706258]
27. H Van de Ven,J Vandervoort,W Weyenberg,S Apers,A Ludwig. (2011-11-04) Mixture designs in the optimisation of PLGA nanoparticles: influence of organic phase composition on β-aescin encapsulation.. Journal of microencapsulation, 29 ((2)): (115-125). [PMID:22047548]
28. Qiang Li,Handong Ouyang,Peizong Wang,Weian Zeng. (2011-11-09) The antinociceptive effect of intrathecal escin in the rat formalin test.. European journal of pharmacology, 674 ((2-3)): (234-238). [PMID:22061687]
29. Xiu-Jun Wu,Meng-Liang Zhang,Xiang-Yong Cui,Feng Gao,Qun He,Xiao-Jiao Li,Ji-Wen Zhang,J Paul Fawcett,Jing-Kai Gu. (2011-11-19) Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat.. Journal of ethnopharmacology, 139 ((1)): (201-206). [PMID:22094055]
30. Yan-Lei Wang,You-Ling Jing,Qing-Yan Cai,Guo-Jin Cui,Yi-Bing Zhang,Feng-Yu Zhang. (2012-06-02) [Effects of sodium aescinate on the apoptosis-related genes in lung injury induced by intestinal ischemia reperfusion in rats].. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 43 ((2)): (170-173). [PMID:22650024]
31. Michael J Morton,Martin J Main. (2012-08-28) Use of escin as a perforating agent on the IonWorks quattro automated electrophysiology platform.. Journal of biomolecular screening, 18 ((1)): (128-134). [PMID:22923788]
32. Wolfgang Sipos,Benjamin Reutterer,Maria Frank,Hermann Unger,Andreas Grassauer,Eva Prieschl-Grassauer,Petra Doerfler. (2012-12-22) Escin inhibits type I allergic dermatitis in a novel porcine model.. International archives of allergy and immunology, 161 ((1)): (44-52). [PMID:23257653]
33. B G Gafurov. (2013-02-08) [Efficacy of the anti-edema drug L-lysine aescinat in stroke].. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112 ((12 Pt 2)): (31-34). [PMID:23388603]
34. Zhihong Yu,Ping Su. (2013-07-24) Effect of beta-aescin extract from Chinese buckeye seed on chronic venous insufficiency.. Die Pharmazie, 68 ((6)): (428-430). [PMID:23875249]
35. Xiu-Jun Wu,Meng-Liang Zhang,Xiang-Yong Cui,J Paul Fawcett,Jing-Kai Gu. (2013-12-18) Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats.. Journal of ethnopharmacology, 151 ((2)): (839-845). [PMID:24334163]
36. Harsimran Singh,Shabir Sidhu,Kanwaljit Chopra,M U Khan. (2017-01-10) The novel role of β-aescin in attenuating CCl. Pharmaceutical biology, 55 ((1)): (749-757). [PMID:28064552]
37. Lisha Shao,Phuong Chung,Allan Wong,Igor Siwanowicz,Clement F Kent,Xi Long,Ulrike Heberlein. (2019-05-11) A Neural Circuit Encoding the Experience of Copulation in Female Drosophila.. Neuron, 102 ((5)): (1025-1036). [PMID:31072787]
38. Gerard Giménez-Ribes,Mehdi Habibi,Leonard M C Sagis. (2019-12-28) Interfacial rheology and relaxation behavior of adsorption layers of the triterpenoid saponin Escin.. Journal of colloid and interface science, 563 (281-290). [PMID:31881493]
39. Claire E McKellar,Igor Siwanowicz,Barry J Dickson,Julie H Simpson. (2020-06-26) Controlling motor neurons of every muscle for fly proboscis reaching.. eLife, 9 [PMID:32584254]
40. Daniel R McHugh,Calvin U Cotton,Craig A Hodges. (2021-01-06) Synergy between Readthrough and Nonsense Mediated Decay Inhibition in a Murine Model of Cystic Fibrosis Nonsense Mutations.. International journal of molecular sciences, 22 ((1)): [PMID:33396210]
41. Da Wang, Luping Sha, Chen Xu, Ying Huang, Chengcheng Tang, Tingting Xu, Xianzhe Li, Donghua Di, Jie Liu, Li Yang. (2022) Natural saponin and cholesterol assembled nanostructures as the promising delivery method for saponin. COLLOIDS AND SURFACES B-BIOINTERFACES, 214 (112448). [PMID:35306344] [10.1016/j.colsurfb.2022.112448]
42. Shengyun Li, Yaowu Yuan, Chenchen Yu, Hao Gao, Jianxin Tan, Yiling Tian. (2020) Establishment and Application of a Method for the Determination of Ganoderic Acid A. JOURNAL OF FOOD QUALITY, 2020 (6621853). [PMID:] [10.1155/2020/6621853]
43. Minyu Zhu, Jinwei Ying, Chaowei Lin, Yu Wang, Kelun Huang, Yang Zhou, Honglin Teng. (2018) β-Escin inhibits the proliferation of osteosarcoma cells via blocking the PI3K/Akt pathway. RSC Advances, 8 (52): (29637-29644). [PMID:35547316] [10.1039/C8RA03578D]

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