Basic Description

Synonyms	Esculin hydrate \| Esculin sesquihydrate \| 66778-17-4 \| CHEBI:73111 \| 1217453-54-7 \| Esculinsesquihydrate \| 7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one;hydrate \| 7-hydroxy-2-oxo-2H-chromen-6-yl beta-D-glucopyranoside--water
Specifications & Purity	for microbiology
Storage Temp	Room temperature
Shipped In	Normal
Grade	for microbiology

Associated Targets(Human)

Endoplasmic reticulum aminopeptidase 2 387 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Endoplasmic reticulum aminopeptidase 1 581 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Geminin 128009 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ataxin-2 54410 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 21853 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Thioredoxin reductase 1, cytoplasmic 45279 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one;hydrate
INCHI	InChI=1S/C15H16O9.H2O/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17;/h1-4,10,12-17,19-21H,5H2;1H2/t10-,12-,13+,14-,15-;/m1./s1
InChi Key	CQYPGSKIFJFVDQ-QWFKVUSTSA-N
Canonical SMILES	C1=CC(=O)OC2=CC(=C(C=C21)OC3C(C(C(C(O3)CO)O)O)O)O.O
Isomeric SMILES	C1=CC(=O)OC2=CC(=C(C=C21)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O.O
Alternate CAS	531-75-9
PubChem CID	16211025
Molecular Weight	367.31

Certificates

Certificate of Analysis(COA)

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Lot Number	Certificate Type	Date	Item
F2328995	Certificate of Analysis	Jun 15, 2023	E433254

Chemical and Physical Properties

Melt Point(°C)	204-206°C

Citations of This Product

1. Yong-Yu Yang, Jing-Jing Qi, Si-Yi Jiang, Ling Ye. (2023) Esculin ameliorates obesity-induced insulin resistance by improving adipose tissue remodeling and activating the IRS1/PI3K/AKT/GLUT4 pathway. JOURNAL OF ETHNOPHARMACOLOGY, (6): (117251). [PMID:37778516]
2. Jiangwei Ni, Ge Li, Ningfeng Dai, Zijiao Quan, Haibin Tong, Yu Liu. (2023) Esculin alleviates LPS-induced acute lung injury via inhibiting neutrophil recruitment and migration. INTERNATIONAL IMMUNOPHARMACOLOGY, 119 (110177). [PMID:37068336]

References

1. Yong-Yu Yang, Jing-Jing Qi, Si-Yi Jiang, Ling Ye. (2023) Esculin ameliorates obesity-induced insulin resistance by improving adipose tissue remodeling and activating the IRS1/PI3K/AKT/GLUT4 pathway. JOURNAL OF ETHNOPHARMACOLOGY, (6): (117251). [PMID:37778516]
2. Jiangwei Ni, Ge Li, Ningfeng Dai, Zijiao Quan, Haibin Tong, Yu Liu. (2023) Esculin alleviates LPS-induced acute lung injury via inhibiting neutrophil recruitment and migration. INTERNATIONAL IMMUNOPHARMACOLOGY, 119 (110177). [PMID:37068336]

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Esculin - suitable for microbiology, high purity , CAS No.66778-17-4