ESI 09 - ≥98%(HPLC), high purity , CAS No.263707-16-0, Inhibitor of Rap guanine nucleotide exchange factor 3;Inhibitor of Rap guanine nucleotide exchange factor 4
ESI 09 - ≥98%(HPLC), high purity , CAS No.263707-16-0, Inhibitor of Rap guanine nucleotide exchange factor 3;Inhibitor of Rap guanine nucleotide exchange factor 4
EPAC inhibitor. Inhibits EPAC-mediated insulin releases from pancreaticβcells. Selective for EPAC over PKA. Decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cellsin vitro.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of Rap guanine nucleotide exchange factor 3;Inhibitor of Rap guanine nucleotide exchange factor 4
Product Description
product description：
ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.
1.Almahariq M, Tsalkova T, Mei FC, Chen H, Zhou J, Sastry SK, Schwede F, Cheng X. (2013) A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion.. Mol Pharmacol, 83 (1):(122-8). [PMID:23066090][10.1021/op500134e]
2.Tsalkova T, Mei FC, Li S, Chepurny OG, Leech CA, Liu T, Holz GG, Woods Jr VL, Cheng X. (2012) Isoform-specific antagonists of exchange proteins directly activated by cAMP.. Proc Natl Acad Sci USA, 109 (45):(18613-8). [PMID:23091014][10.1021/op500134e]
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J2130395