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EST64454 , CAS No.E610188, Antagonist of sigma non-opioid intracellular receptor 1

EST64454 , CAS No.E610188, Antagonist of sigma non-opioid intracellular receptor 1

Item Number

E610188

Grouped product items
SKU	Size	Availability	Price	Qty
E610188-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$270.90
E610188-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$940.90

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Basic Description

Synonyms	compound 9k;EST-64454;example 39 [WO2011147910A1]
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of sigma non-opioid intracellular receptor 1

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone
INCHI	InChI=1S/C18H22F2N4O2/c1-14(25)23-8-6-22(7-9-23)10-11-26-13-15-4-5-24(21-15)16-2-3-17(19)18(20)12-16/h2-5,12H,6-11,13H2,1H3
InChi Key	COKUNRYWXTVUAH-UHFFFAOYSA-N
Canonical SMILES	CC(=O)N1CCN(CC1)CCOCc1ccn(n1)c1ccc(c(c1)F)F
Isomeric SMILES	CC(=O)N1CCN(CC1)CCOCC2=NN(C=C2)C3=CC(=C(C=C3)F)F
PubChem CID	54673648

PubChem CID	54673648

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1. Díaz JL, García M, Torrens A, Caamaño AM, Enjo J, Sicre C, Lorente A, Port A, Montero A,Yeste S et al.. (2020) EST64454: a Highly Soluble σ 1 Receptor Antagonist Clinical Candidate for Pain Management. J Med Chem, 129 (3): (589-97). [PMID:33237785]

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