Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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E105516-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $103.90 |
Synonyms | 2DI9HA706A | Cristallovar | delta-1,3,5-estratrien-3-beta-ol-17-one | delta-1,3,5-Estratrien-3beta-ol-17-one | ESTRONE [USP-RS] | NSC-9699 | Ovifollin | Unden (pharmaceutical) | Estrona [INN-Spanish] | Thelykinin | Wynestron | Estrone [USP:INN:BAN] | Keto |
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Specifications & Purity | Moligand™, analytical standard |
Biochemical and Physiological Mechanisms | Estrone is a luteolytic estrogen produced by the corpus luteum. |
Shipped In | Normal |
Grade | analytical standard, Moligand™ |
Action Type | AGONIST |
Mechanism of action | Estrogen receptor alpha agonist |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one |
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INCHI | InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 |
InChi Key | DNXHEGUUPJUMQT-CBZIJGRNSA-N |
Canonical SMILES | CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O |
Isomeric SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)O |
WGK Germany | 3 |
RTECS | KG8575000 |
PubChem CID | 5870 |
Molecular Weight | 270.37 |
Beilstein | 1915077 |
PubChem CID | 5870 |
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DrugBank Ligand | DB00655 |
ChEMBL Ligand | CHEMBL1405 |
BindingDB Ligand | 25829 |
ChEBI | CHEBI:17263 |
Wikipedia | Estrone |
CAS Registry No. | 53-16-7 |
NURSA Ligand | 10.1621/LI9XVGKA6N |
RCSB PDB Ligand | J3Z |
DrugCentral Ligand | 3188 |
Enter Lot Number to search for COA:
Specific Rotation[α] | 165 ° (C=1, Dioxane) |
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Melt Point(°C) | 258-260°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H360:May damage fertility or the unborn child H350:May cause cancer H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
WGK Germany | 3 |
RTECS | KG8575000 |
Merck Index | 3708 |
1. Cheng Yang, Zheng–Lian Mo, Qiu–Fang Zhang, Jin–Jie Xu, Xiao–Fang Shen, Yue–Hong Pang. (2024) Membrane–protected magnetic covalent organic framework for efficient extraction of estrogens in dairy products. FOOD CHEMISTRY, 438 (14): (137984). [PMID:37979275] [10.1016/j.foodchem.2023.137984] |
2. Dongyang Liu, Hanzhi Wang, Yue Teng, Qirui Wu, Chunming Tang, Xinxin Gao, Chaoqi Chen, Liandong Zhu. (2023) Biochemical responses of freshwater microalgae Chlorella sorokiniana to combined exposure of Zn(Ⅱ) and estrone with simultaneous pollutants removal. JOURNAL OF ENVIRONMENTAL MANAGEMENT, 348 (22): (119392). [PMID:37879179] [10.1016/j.jenvman.2023.119392] |
3. Yue Bao, Yixin Zhai, Siyuan Di, Hailan Qin, Shukui Zhu. (2023) Room-temperature synthesis of magnetic thiophene-based covalent organic frameworks for derivatization-assisted GC–MS analysis of estrogens in environmental water. MICROCHEMICAL JOURNAL, 195 (7): (109524). [PMID:16281057] [10.1016/j.microc.2023.109524] |
4. Sailing Chen, Shaowei Wang, Jingyi Zheng, Han Lu, Huiqian Chen, Yunbing Tang, Nan Wang, Yang Zhu, Yiyan Wang, Ping Duan, Ren-shan Ge. (2023) Bisphenol analogues inhibit human and rat 17β-hydroxysteroid dehydrogenase 1: 3D-quantitative structure-activity relationship (3D-QSAR) and in silico docking analysis. FOOD AND CHEMICAL TOXICOLOGY, 181 (114052). [PMID:37758047] [10.1016/j.fct.2023.114052] |
5. Tianrun Qian, Jia Bao, Xuepeng Liu, Gerile Oudeng, Weiwei Ye. (2023) A “turn-on” fluorescence resonance energy transfer aptasensor based on carbon dots and gold nanoparticles for 17β-estradiol detection in sea salt. RSC Advances, 13 (40): (27772-27781). [PMID:37731834] [10.1039/D3RA05410A] |
6. Yachao Hao, Wei Zhou, Xin Wang, Youping Liu, Xin Di. (2023) Carboxyl-based deep eutectic solvent modified magnetic graphene oxide as a novel adsorbent for fast enrichment and extraction of estrogens in milk prior to HPLC-UV analysis. MICROCHEMICAL JOURNAL, 193 (109050). [PMID:] [10.1016/j.microc.2023.109050] |
7. Qingqing Zhou, Yunli Duan, Zhigang Xu, Yu Tian, Zhimin Liu, Chunbo Liu, Pei He, Zhihua Liu, Xiaoxi Si. (2023) A molecularly imprinted fiber array solid-phase microextraction strategy for simultaneous detection of multiple estrogens. Journal of Materials Chemistry B, 11 (22): (4991-4999). [PMID:37218576] [10.1039/D3TB00555K] |
8. Jing Yang, Hao Liu, Yan Huang, Li Li, Xiaoli Zhu, Yaping Ding. (2023) One-step hydrothermal synthesis of near-infrared emission carbon quantum dots as fluorescence aptamer sensor for cortisol sensing and imaging. TALANTA, 260 (124637). [PMID:37172433] [10.1016/j.talanta.2023.124637] |
9. Lixia Lu, Bingchan Song, Jianwen Gao, Xinyu Shao. (2023) A ratiometric aptasensor for simultaneous determination of two estrogens based on multicolor upconversion nanoparticles. SENSORS AND ACTUATORS B-CHEMICAL, 389 (133842). [PMID:] [10.1016/j.snb.2023.133842] |
10. Qing Liu, Chao Yan, Yan Wang. (2023) Submicron Nonporous Silica Particles for Enhanced Separation Performance in pCEC. MOLECULES, 28 (8): (3542). [PMID:37110774] [10.3390/molecules28083542] |
11. Di Li, Ting Sun, Yongqing Tong, Juan Le, Qian Yao, Jun Tao, Hang Liu, Woer Jiao, Yufeng Mei, Jingru Chen, Zhongchun Liu, Gaohua Wang, Yan Li. (2023) Gut-microbiome-expressed 3β-hydroxysteroid dehydrogenase degrades estradiol and is linked to depression in premenopausal females. Cell Metabolism, 35 (685-694.e5). [PMID:36933555] [10.1016/j.cmet.2023.02.017] |
12. Xuan Ma, Yue Wang, Wenting Wang, Jake Heinlein, Lisa D. Pfefferle, Xuemeng Tian. (2023) Strategic preparation of porous magnetic molecularly imprinted polymers via a simple and green method for high-performance adsorption and removal of meropenem. TALANTA, 258 (124419). [PMID:36893497] [10.1016/j.talanta.2023.124419] |
13. Haojie Zeng, Feiyun Sun, Jianjun Zhang, Ying Wang, Songwen Yang, Dingyu Xing. (2023) Gradient crosslinking optimization for the selective layer to prepare polyvinyl alcohol (PVA) nanofiltration (NF) membrane: The enhanced filtration performance and potential rejection for EDCs. JOURNAL OF MEMBRANE SCIENCE, 675 (121548). [PMID:] [10.1016/j.memsci.2023.121548] |
14. Xuhong Cai, Junbo Liu, Dadong Liang, Shanshan Tang, Bao Xu. (2023) Construction of a QCM sensor for detecting diethylstilbestrol in water based on the computational design of molecularly imprinted polymers. Arabian Journal of Chemistry, 16 (104601). [PMID:] [10.1016/j.arabjc.2023.104601] |
15. Sun Min, Wang Xiuqin, Ding Yali, Feng Juanjuan. (2022) Titania hybridized melamine–formaldehyde aerogel for online in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons prior to HPLC–DAD. MICROCHIMICA ACTA, 189 (12): (1-10). [PMID:36416994] [10.1007/s00604-022-05572-3] |
16. Lanbo Bi, Jimin Shen, Zhuoran Yao, Jing Kang, Shengxin Zhao, Pengwei Yan, Binyuan Wang, Zhonglin Chen. (2022) Preparation and Adsorption Properties of Magnetic Molecularly Imprinted Polymers for Selective Recognition of 17β-Estradiol. Separations, 9 (11): (381). [PMID:] [10.3390/separations9110381] |
17. Pengfei Zhao, Sisi Tang, Xiaodan Wu, Yu Chen, Kangling Tang, Jinli Fu, Huibin Lei, ZhaoXia Yang, Zhaohui Zhang. (2023) Imprinted ratiometric fluorescence capillary sensor based on UiO-66-NH2 for rapid determination of sialic acid. TALANTA, 253 (124081). [PMID:] [10.1016/j.talanta.2022.124081] |
18. Liangliang He, Chanjuan Chen, Shuyi Duan, Yang Li, Chuan Li, Xinsheng Yao, Frank J. Gonzalez, Zifei Qin, Zhihong Yao. (2023) Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 225 (106182). [PMID:36152789] [10.1016/j.jsbmb.2022.106182] |
19. Xian Liu, Like Chen, Yang Yang, Liping Xu, Junyong Sun, Tian Gan. (2023) MXene−reinforced octahedral PtCu nanocages with boosted electrocatalytic performance towards endocrine disrupting pollutants sensing. JOURNAL OF HAZARDOUS MATERIALS, 442 (130000). [PMID:36137886] [10.1016/j.jhazmat.2022.130000] |
20. Yanqun Yang, Yipeng Huang, Zhuqiang Wu, Rui Shi, Zhengyi Chen, Guihua Ruan. (2022) Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens. ANALYTICA CHIMICA ACTA, 1227 (340270). [PMID:36089309] [10.1016/j.aca.2022.340270] |
21. Shuo Qi, Xiaoze Dong, Yuhan Sun, Yin Zhang, Nuo Duan, Zhouping Wang. (2022) Split aptamer remodeling-initiated target-self-service 3D-DNA walker for ultrasensitive detection of 17β-estradiol. JOURNAL OF HAZARDOUS MATERIALS, 439 (129590). [PMID:35872451] [10.1016/j.jhazmat.2022.129590] |
22. Zhang Qianchun, Wang Yutong, Yang Bingnian, Bao Linchun, Wu Yun, Wang Xingyi. (2022) Development of an Efficient Solid-Phase Microextraction Monolithic Column for the Analysis of Estrogens in Human Urine and Serum Samples. CHROMATOGRAPHIA, 85 (8): (733-741). [PMID:] [10.1007/s10337-022-04178-4] |
23. Hui Lyu, Xinze Wu, Yinpeng Yang, Huaixia Chen, Xueping Dang, Xiaolan Liu. (2022) Preparation, characterization and application of double yolk–shell structure magnetic molecularly imprinted polymers for extraction of 17β-estradiol. NEW JOURNAL OF CHEMISTRY, 46 (24): (11927-11933). [PMID:] [10.1039/D2NJ00237J] |
24. Yuping Zhang, Ning Wang, Zhenyu Lu, Na Chen, Chengxing Cui, Xinxin Chen. (2022) Smart Titanium Wire Used for the Evaluation of Hydrophobic/Hydrophilic Interaction by In-Tube Solid Phase Microextraction. MOLECULES, 27 (7): (2353). [PMID:35408750] [10.3390/molecules27072353] |
25. Cui Hanyue, Lu Huan, Yang Jing, Fu Yao, Huang Yan, Li Li, Ding Yaping. (2022) A Significant Fluorescent Aptamer Sensor Based on Carbon Dots and Graphene Oxide for Highly Selective Detection of Progesterone. JOURNAL OF FLUORESCENCE, 32 (3): (927-936). [PMID:35119576] [10.1007/s10895-022-02896-4] |
26. Huizhong Si, Pingping He, Xuemei Wang, Lin Li, Xiaohong Hou. (2022) Metal organic framework/chitosan/polyethylene oxide composite columnar foam as a sorbent for the enrichment and determination of estrogens in environmental aqueous solutions. NEW JOURNAL OF CHEMISTRY, 46 (2): (808-819). [PMID:] [10.1039/D1NJ02426D] |
27. Mingxia Sun, Juanjuan Feng, Jiaqing Feng, Haili Sun, Yang Feng, Xiangping Ji, Chunying Li, Sen Han, Min Sun. (2022) Biochar nanosphere- and covalent organic framework nanosphere-functionalized titanium dioxide nanorod arrays on carbon fibers for solid-phase microextraction of organic pollutants. CHEMICAL ENGINEERING JOURNAL, 433 (133645). [PMID:] [10.1016/j.cej.2021.133645] |
28. Qingyi Wei, Peiyao Zhang, Hongbin Pu, Da-Wen Sun. (2022) A fluorescence aptasensor based on carbon quantum dots and magnetic Fe3O4 nanoparticles for highly sensitive detection of 17β-estradiol. FOOD CHEMISTRY, 373 (131591). [PMID:34823936] [10.1016/j.foodchem.2021.131591] |
29. Yue Wang, Wenchang Zhao, Ruixia Gao, Sameer Hussain, Yi Hao, Jiahao Tian, Shihui Chen, Yunhao Feng, Yubo Zhao, Yuyao Qu. (2022) Preparation of lightweight daisy-like magnetic molecularly imprinted polymers via etching synergized template immobilization for enhanced rapid detection of trace 17β-estradiol. JOURNAL OF HAZARDOUS MATERIALS, 424 (127216). [PMID:34592596] [10.1016/j.jhazmat.2021.127216] |
30. Xiaoxiao Zhu, Yijun Zhang, Pengfei Liu, Xiuzhi Bai, Na Chen, Yuping Zhang. (2021) Carbonized Aramid Fiber as the Adsorbent for In-Tube Solid-Phase Microextraction to Detect Estrogens in Water Samples. Journal of Chemistry, 2021 (9970518). [PMID:] [10.1155/2021/9970518] |
31. Yi Zhang, Lingling Wang, Wen-Long Wang, Cheng Yang, Yongwei Feng, Xueli Shi. (2021) Visual-afterglow dual-mode immunochromatographic strip for 17β-estradiol detection in milk. TALANTA, 232 (122427). [PMID:34074413] [10.1016/j.talanta.2021.122427] |
32. Kejian Tian, Fanxing Meng, Qi Meng, Yan Gao, Lili Zhang, Le Wang, Yuqing Wang, Xue Li, Hongliang Huo. (2020) The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001. International Journal of Genomics, 2020 (9369182). [PMID:32908857] [10.1155/2020/9369182] |
33. Xiangqiong Jiang, Guihua Ruan, Wenjuan Zhang, Yan Zhang, Fuyou Du, Zhengyi Chen. (2020) Preparation of porous polymers based on high internal phase emulsion for enrichment of estrogens in urine. JOURNAL OF SEPARATION SCIENCE, 44 (6): (1140-1147). [PMID:32725854] [10.1002/jssc.202000566] |
34. Xing Tian, Huijia Song, Yue Wang, Xuemeng Tian, Yuhai Tang, Ruixia Gao, Chengxiao Zhang. (2020) Hydrophilic magnetic molecularly imprinted nanobeads for efficient enrichment and high performance liquid chromatographic detection of 17beta-estradiol in environmental water samples. TALANTA, 220 (121367). [PMID:32928396] [10.1016/j.talanta.2020.121367] |
35. Shenling Wang, Yanling Geng, Xiaowei Sun, Rongyu Wang, Zhenjia Zheng, Shenghuai Hou, Xiao Wang, Wenhua Ji. (2020) Molecularly imprinted polymers prepared from a single cross-linking functional monomer for solid-phase microextraction of estrogens from milk. JOURNAL OF CHROMATOGRAPHY A, 1627 (461400). [PMID:32823105] [10.1016/j.chroma.2020.461400] |
36. Shasha Pang, Xianwen Kan. (2020) One-pot synthesis of nitrogen doped graphene-thionine-gold nanoparticles composite for electrochemical sensing of diethylstilbestrol and H2O2. MICROCHEMICAL JOURNAL, 157 (104924). [PMID:] [10.1016/j.microc.2020.104924] |
37. Yuhan Zhu, Zuwei Xu, Jie Gao, Weihao Ji, Jingdong Zhang. (2020) An antibody-aptamer sandwich cathodic photoelectrochemical biosensor for the detection of progesterone. BIOSENSORS & BIOELECTRONICS, 160 (112210). [PMID:32339148] [10.1016/j.bios.2020.112210] |
38. Yinpeng Yang, Yuan Sun, Hang Chen, Xueping Dang, Youhong Ai, Xiaolan Liu, Huaixia Chen. (2020) Mesoporous yolk–shell structure molecularly imprinted magnetic polymers for the extraction and detection of 17β-estradiol. Analytical Methods, 12 (4): (507-513). [PMID:] [10.1039/C9AY02360G] |
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