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ETC-206 (AUM 001) - 98%, high purity , CAS No.1464151-33-4, Inhibitor of MAPK interacting serine/threonine kinase 1;Inhibitor of MAPK interacting serine/threonine kinase 2

Moligand™
≥98%

CAS#: 1464151-33-4
Formula: C₂₅H₂₀N₄O₂
Molecular Weight: 408.45
PubChem CID: 71766360

Item Number

E413572

Grouped product items
SKU	Size	Availability	Price
E413572-5mg	5mg	In stock	$98.90
E413572-10mg	10mg	In stock	$177.90
E413572-25mg	25mg	In stock	$400.90
E413572-50mg	50mg	In stock	$474.90
E413572-100mg	100mg	In stock	$771.90

MNK Inhibitors

View related series

MAPK interacting serine/threonine kinase 1 Inhibitor MAPK interacting serine/threonine kinase 2 Inhibitor

Basic Description

Synonyms	ETC-206\|1464151-33-4\|Tinodasertib\|4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile\|AUM001\|AUM-001\|MND3WX2R7I\|ETC1907206\|ETC206\|4-[6-[4-(morpholine-4-carbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl]benzonitrile\|Benzonitrile, 4-(6-(4
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	ETC-206 (AUM 001, ETC-1907206) is an orally available highly selective small-molecule MNK 1/2 inhibitor with IC50s of 64 nM and 86 nM, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of MAPK interacting serine/threonine kinase 1;Inhibitor of MAPK interacting serine/threonine kinase 2

ALogP

3.016

Rotatable Bond

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MKNK2 Tchem MAP kinase-interacting serine/threonine-protein kinase 2 1 Activities

Discover Target: MKNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MKNK1 Tchem MAP kinase-interacting serine/threonine-protein kinase 1 1 Activities

Discover Target: MKNK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP2K2 Tclin Dual specificity mitogen-activated protein kinase kinase 2 0 Activities

Discover Target: MAP2K2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATP7A Tbio Copper-transporting ATPase 1 0 Activities

Discover Target: ATP7A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[6-[4-(morpholine-4-carbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl]benzonitrile
INCHI	InChI=1S/C25H20N4O2/c26-15-18-1-3-20(4-2-18)23-16-27-24-10-9-22(17-29(23)24)19-5-7-21(8-6-19)25(30)28-11-13-31-14-12-28/h1-10,16-17H,11-14H2
InChi Key	FWRFPHJSGLYXTD-UHFFFAOYSA-N
Canonical SMILES	C1COCCN1C(=O)C2=CC=C(C=C2)C3=CN4C(=NC=C4C5=CC=C(C=C5)C#N)C=C3
Isomeric SMILES	C1COCCN1C(=O)C2=CC=C(C=C2)C3=CN4C(=NC=C4C5=CC=C(C=C5)C#N)C=C3
PubChem CID	71766360
Molecular Weight	408.45

CAS Registry No.

PubChem CID

ChEMBL Ligand

BindingDB Ligand

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
K2229046	Certificate of Analysis	Oct 09, 2022	E413572
K2229047	Certificate of Analysis	Oct 09, 2022	E413572
K2229048	Certificate of Analysis	Oct 09, 2022	E413572
K2229054	Certificate of Analysis	Oct 09, 2022	E413572
K2229055	Certificate of Analysis	Oct 09, 2022	E413572

Solubility

Solubility (25°C) In vitro DMSO: 82 mg/mL (200.75 mM); Water: Insoluble; Ethanol: Insoluble;

DMSO(mg / mL) Max Solubility

DMSO(mM) Max Solubility

200.758966825805

Water(mg / mL) Max Solubility

＜1

References

1. Jin X, Yu R, Wang X, Proud CG, Jiang T. (2021) Progress in developing MNK inhibitors.. Eur J Med Chem, 219 (3): (113420). [PMID:33892273]
2. Yang H, Chennamaneni LR, Ho MWT, Ang SH, Tan ESW, Jeyaraj DA, Yeap YS, Liu B, Ong EH, Joy JK et al.. (2018) Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.. J Med Chem, 61 (10): (4348-4369). [PMID:29683667]
3. Teneggi V, Novotny-Diermayr V, Lee LH, Yasin M, Yeo P, Ethirajulu K, Gan SBH, Blanchard SE, Nellore R, Umrani DN et al.. (2020) First-in-Human, Healthy Volunteers Integrated Protocol of ETC-206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug.. Clin Transl Sci, 13 (1): (57-66). [PMID:31343094]

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