etelcalcetide, Calcium sensing receptor agonist, CAS No.rp173978, Calcium sensing receptor agonist

Features and benefits
    Item Number
    rp173978
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp173978-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp173978-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90

    Basic Description

    Product Nameetelcalcetide, Calcium sensing receptor agonist, CAS No.rp173978
    SynonymsEtelcalcetidum | Velcalcetide | Telcalcetide | ONO-5163 | BS-14875 | ETELCALCETIDE [WHO-DD] | SCHEMBL21982605 | HY-P1955 | 1262780-97-1 | DTXSID70155132 | H05BX04 | Parsabiv | CHEBI:134700 | DTXCID2077623 | D-Argininamide, N-acetyl-D-cysteinyl-D-alanyl-D-
    GradeMoligand™
    Specifications & PurityMoligand™
    Action TypeAGONIST, ALLOSTERIC MODULATOR
    Mechanism of actionCalcium sensing receptor agonist

    Associated Targets(Human)

    CASR Tclin Extracellular calcium-sensing receptor (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp173978

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate NamesEtelcalcetidum | Velcalcetide | Telcalcetide | ONO-5163 | BS-14875 | ETELCALCETIDE [WHO-DD] | SCHEMBL21982605 | HY-P1955 | 1262780-97-1 | DTXSID70155132 | H05BX04 | Parsabiv | CHEBI:134700 | DTXCID2077623 | D-Argininamide, N-acetyl-D-cysteinyl-D-alanyl-D-
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Walter S, Baruch A, Dong J, Tomlinson JE, Alexander ST, Janes J, Hunter T, Yin Q, Maclean D, Bell G et al..  (2013)  Pharmacology of AMG 416 (Velcalcetide), a novel peptide agonist of the calcium-sensing receptor, for the treatment of secondary hyperparathyroidism in hemodialysis patients..  J Pharmacol Exp Ther,  346  (2): (229-40).  [PMID:23674604] [10.1021/op500134e]

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