Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E135204-1g | 1g | In stock | $68.90 | |
E135204-5g | 5g | In stock | $309.90 |
Potent Glutathione S-transferase (GST) inhibitor
Synonyms | ETHACRYNIC ACID | Etacrynic Acid | 58-54-8 | ethacrynate | Edecrin | Etacrinic acid | Hydromedin | Taladren | Crinuryl | Edecril | Edecrina | Endecril | Hidromedin | Otacril | Mingit | Reomax | Uregit | Etakrinic acid | Methylenebutyrylphenoxyacetic acid | MK-595 | Ethacrinique (acide) | Acido et |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at 2-8°C,Protected from light |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Sodium-(potassium)-chloride cotransporter 2 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers. |
ALogP | 3.8 |
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IUPAC Name | 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid |
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INCHI | InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17) |
InChi Key | AVOLMBLBETYQHX-UHFFFAOYSA-N |
Canonical SMILES | CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl |
Isomeric SMILES | CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl |
WGK Germany | 1 |
PubChem CID | 3278 |
Molecular Weight | 303.14 |
DrugBank Ligand | DB00903 |
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PubChem CID | 3278 |
CAS Registry No. | 58-54-8 |
ChEMBL Ligand | CHEMBL456 |
Wikipedia | Ethacrynic acid |
ChEBI | CHEBI:4876 |
RCSB PDB Ligand | EAA |
DrugCentral Ligand | 1071 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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I2217295 | Certificate of Analysis | Jul 16, 2024 | E135204 |
I2217296 | Certificate of Analysis | Jul 16, 2024 | E135204 |
H2328640 | Certificate of Analysis | Aug 10, 2023 | E135204 |
H2328641 | Certificate of Analysis | Aug 10, 2023 | E135204 |
H2328664 | Certificate of Analysis | Aug 10, 2023 | E135204 |
H2328748 | Certificate of Analysis | Aug 10, 2023 | E135204 |
C2308364 | Certificate of Analysis | Jul 29, 2022 | E135204 |
E2223307 | Certificate of Analysis | May 28, 2022 | E135204 |
Solubility | Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water., Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water. |
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Sensitivity | light sensitive |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 1 |
Starting at $69.90
Starting at $50.90
1. D'Onofrio N et al.. (2021) SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells.. Cancers (Basel), 13 (20): [PMID:34680344] |
2. Ying Wen, Zhiqing Long, Xiaoxia Bai, Fangjun Huo, Caixia Yin. (2022) Specific fluorescence release based on synergistic activation of enzymes and position-dependent of electrophilic groups to diagnose intrahepatic cholestasis of pregnancy. CHEMICAL ENGINEERING JOURNAL, 440 (135978). [PMID:] |