Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E129595-1g | 1g | In stock | $58.90 | |
E129595-5g | 5g | In stock | $176.90 | |
E129595-25g | 25g | In stock | $795.90 |
Potent estrogen receptor agonist
Synonyms | Ethinylestradiol (Standard) | Ethynyloestradiol | Estigyn | 17-Ethinylestradiol | CHEBI:4903 | Ethinyl Estradiol [USP] | Ethynyl estradiol | Lynoral | Primogyn | 17a-Ethinylestradiol | 17a-Ethynylestradiol | 17-Ethynylestradiol | 423D2T571U | Ethinylestra |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Ethynyl Estradiol is a synthetic analog of estradiol, often used in combination with a progestin. Efficacy of administration is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Rapidly absorbed fr |
Storage Temp | Protected from light,Argon charged |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST, INHIBITOR |
Mechanism of action | Estrogen receptor alpha agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A synthetic estradiol analog. |
ALogP | 3.7 |
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Pubchem Sid | 488179981 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179981 |
IUPAC Name | (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol |
INCHI | InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1 |
InChi Key | BFPYWIDHMRZLRN-SLHNCBLASA-N |
Canonical SMILES | CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O |
Isomeric SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O |
WGK Germany | 3 |
RTECS | RC8925000 |
PubChem CID | 5991 |
Molecular Weight | 296.4 |
Beilstein | 2419975 |
Reaxy-Rn | 7177007 |
DrugBank Ligand | DB00977 |
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PubChem CID | 5991 |
CAS Registry No. | 57-63-6 |
ChEMBL Ligand | CHEMBL691 |
Wikipedia | Ethinyl estradiol |
ChEBI | CHEBI:4903 |
NURSA Ligand | 10.1621/XLZYGNE63I |
RCSB PDB Ligand | 3WF |
PEP | ethinylestradiol |
DrugCentral Ligand | 1082 |
PubChem SID | 488179981 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2202433 | Certificate of Analysis | Jun 15, 2024 | E129595 |
E2112314 | Certificate of Analysis | Feb 13, 2023 | E129595 |
E2112312 | Certificate of Analysis | Feb 13, 2023 | E129595 |
E2112311 | Certificate of Analysis | Feb 13, 2023 | E129595 |
D23141567 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142118 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142185 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142186 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142221 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142227 | Certificate of Analysis | Jan 09, 2023 | E129595 |
A2418083 | Certificate of Analysis | Jul 23, 2022 | E129595 |
I2202365 | Certificate of Analysis | Jul 23, 2022 | E129595 |
I2202432 | Certificate of Analysis | Jul 23, 2022 | E129595 |
Solubility | Soluble in ethanol (59 mg/ml at 25 °C), DMF (~20 mg/ml), DMSO (59 mg/ml at 25 °C), water (0.01 mg/ml at 27 °C), and methanol. |
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Sensitivity | light sensitive;Air sensitive |
Specific Rotation[α] | -30° (C=0.4,Pyridine) |
Melt Point(°C) | 181.0 - 185.0°C |
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H350:May cause cancer H362:May cause harm to breast-fed children |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | RC8925000 |
Reaxy-Rn | 7177007 |
Merck Index | 3734 |
1. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2024) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169170). [PMID:38072270] |
2. Yanting Li, Shu Zhu, Hua Zhao, Yan Xiong, Tao Gong, Yanru Tao, Jin Li, Jiangling Hu, Hongmei Wang, Xinhui Jiang. (2024) Cubic cobalt ferrite anchored on graphene sheets for non-enzymatic electrochemical detection of 17α-ethinyl estradiol in environmental and biological samples. Journal of Environmental Chemical Engineering, 12 (111612). [PMID:] |
3. Yue Bao, Yixin Zhai, Siyuan Di, Hailan Qin, Shukui Zhu. (2023) Room-temperature synthesis of magnetic thiophene-based covalent organic frameworks for derivatization-assisted GC–MS analysis of estrogens in environmental water. MICROCHEMICAL JOURNAL, 195 (7): (109524). [PMID:16281057] |
4. Yachao Hao, Wei Zhou, Xin Wang, Youping Liu, Xin Di. (2023) Carboxyl-based deep eutectic solvent modified magnetic graphene oxide as a novel adsorbent for fast enrichment and extraction of estrogens in milk prior to HPLC-UV analysis. MICROCHEMICAL JOURNAL, 193 (109050). [PMID:] |
5. Si-xuan Zhou, Xiao-tong Lin, Jie Wang, Hai-xiang Wang, Gui-tang Chen. (2023) Novel hydrocortisone magnetic molecularly imprinted polymers: Preparation, characterization, and application. FOOD CHEMISTRY, 421 (136196). [PMID:37116443] |
6. Qing Liu, Chao Yan, Yan Wang. (2023) Submicron Nonporous Silica Particles for Enhanced Separation Performance in pCEC. MOLECULES, 28 (8): (3542). [PMID:37110774] |
7. Haojie Zeng, Feiyun Sun, Jianjun Zhang, Ying Wang, Songwen Yang, Dingyu Xing. (2023) Gradient crosslinking optimization for the selective layer to prepare polyvinyl alcohol (PVA) nanofiltration (NF) membrane: The enhanced filtration performance and potential rejection for EDCs. JOURNAL OF MEMBRANE SCIENCE, 675 (121548). [PMID:] |
8. Lei Miao, Shanshan Sun, Tian Ma, Yousif Abdelrahman Yousif Abdellah, Yue Wang, Yaozu Mi, Haohao Yan, Guanjun Sun, Ning Hou, Xinyue Zhao, Chunyan Li, Hailian Zang. (2023) A Novel Estrone Degradation Gene Cluster and Catabolic Mechanism in Microbacterium oxydans ML-6. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 89 (3): [PMID:36847539] |
9. Yunning Chen, Renquan Guan, Xueying Cheng, Jie Zhao, Zhengkai Wu, Yan Wang, Qingkun Shang, Yingnan Sun. (2023) Construction of surface oxygen vacancies by bimetallic doping combined with ellagic acid modification to enhance the photocatalytic degradation of ethinyl estradiol by TiO2. CHEMICAL ENGINEERING JOURNAL, 455 (140929). [PMID:] |
10. Sun Min, Wang Xiuqin, Ding Yali, Feng Juanjuan. (2022) Titania hybridized melamine–formaldehyde aerogel for online in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons prior to HPLC–DAD. MICROCHIMICA ACTA, 189 (12): (1-10). [PMID:36416994] |
11. Jinyi Qin, Jiao Fang, Fei Gao, Yiwen He, Ming Su, Yu Zhang, Min Yang. (2023) Oriented bio-feeding control of the anaerobic biodegradation of ethinyl estradiol. CHEMOSPHERE, 311 (137007). [PMID:36330982] |
12. Xian Liu, Like Chen, Yang Yang, Liping Xu, Junyong Sun, Tian Gan. (2023) MXene−reinforced octahedral PtCu nanocages with boosted electrocatalytic performance towards endocrine disrupting pollutants sensing. JOURNAL OF HAZARDOUS MATERIALS, 442 (130000). [PMID:36137886] |
13. Yan Wu, Panpan Cao, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Zhengwu Bai, Sheng Tang. (2022) Ingenious introduction of aminopropylimidazole to tune the hydrophobic selectivity of dodecyl-bonded stationary phase for environmental organic pollutants. MICROCHEMICAL JOURNAL, 182 (107933). [PMID:] |
14. Yanqun Yang, Yipeng Huang, Zhuqiang Wu, Rui Shi, Zhengyi Chen, Guihua Ruan. (2022) Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens. ANALYTICA CHIMICA ACTA, 1227 (340270). [PMID:36089309] |
15. Yong Zhang, Kaifang Wei, Litao Wang, Guihua Gao. (2022) A membrane solid-phase extraction method based on MIL-53-mixed-matrix membrane for the determination of estrogens and parabens: Polyvinylidene difluoride membrane versus polystyrene-block-polybutadiene membrane. BIOMEDICAL CHROMATOGRAPHY, 36 (11): (e5454). [PMID:35853840] |
16. Shuo Qi, Xiaoze Dong, Yuhan Sun, Yin Zhang, Nuo Duan, Zhouping Wang. (2022) Split aptamer remodeling-initiated target-self-service 3D-DNA walker for ultrasensitive detection of 17β-estradiol. JOURNAL OF HAZARDOUS MATERIALS, 439 (129590). [PMID:35872451] |
17. Yan Du, Xiaohui Yan, Yuanbo Chen, Yi Wu, Qiankun Qiu, Yanshuo Li, Dapeng Wu. (2022) Magnetic polyimide nanosheet microspheres for trace analysis of estrogens in aqueous samples by magnetic solid-phase extraction-gas chromatography–mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1675 (463184). [PMID:35675733] |
18. Li Chen, Tahir Maqbool, Ghazanfar Nazir, Congyu Hou, Yulong Yang, Jianning Guo, Xihui Zhang. (2022) Developing the large-area manganese-based catalytic ceramic membrane for peroxymonosulfate activation: Applications in degradation of endocrine disrupting compounds in drinking water. JOURNAL OF MEMBRANE SCIENCE, 655 (120602). [PMID:] |
19. Yuping Zhang, Ning Wang, Zhenyu Lu, Na Chen, Chengxing Cui, Xinxin Chen. (2022) Smart Titanium Wire Used for the Evaluation of Hydrophobic/Hydrophilic Interaction by In-Tube Solid Phase Microextraction. MOLECULES, 27 (7): (2353). [PMID:35408750] |
20. Long Zhu, Mingrong Wang, Shuo Fu, Kaiqi Li, Jialin Liu, Zaizhao Wang. (2022) BPA disrupted the testis testosterone levels by interfering ER enrichments within StAR 5′ flanking region in rare minnow Gobiocypris rarus. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 257 (109338). [PMID:35381366] |
21. Lingli Zhang, Han Tao, Chun Ji, Qiaoling Wu, Xiao Wang, Yuangeng Wu. (2022) Sensitive and direct electrochemical detection of bisphenol S based on 1T&2H-MoS2/CNTs-NH2 nanocomposites. NEW JOURNAL OF CHEMISTRY, 46 (17): (8203-8214). [PMID:] |
22. Cai Xiunan, Tian Ling, Chen Meifei, Liu Yijun, Wang Wei, Long Junhao, Zhang Yanjuan, Tao Gan, Hu Huayu, Huang Zuqiang. (2022) Construction of a C-decorated and Cu-doped (Fe,Cu)S/CuFe2O4 solid solution for photo-Fenton degradation of hydrophobic organic contaminant: Enhanced electron transfer and adsorption capacity. CHEMOSPHERE, 296 (134005). [PMID:35181432] |
23. Huizhong Si, Pingping He, Xuemei Wang, Lin Li, Xiaohong Hou. (2022) Metal organic framework/chitosan/polyethylene oxide composite columnar foam as a sorbent for the enrichment and determination of estrogens in environmental aqueous solutions. NEW JOURNAL OF CHEMISTRY, 46 (2): (808-819). [PMID:] |
24. Mingxia Sun, Juanjuan Feng, Jiaqing Feng, Haili Sun, Yang Feng, Xiangping Ji, Chunying Li, Sen Han, Min Sun. (2022) Biochar nanosphere- and covalent organic framework nanosphere-functionalized titanium dioxide nanorod arrays on carbon fibers for solid-phase microextraction of organic pollutants. CHEMICAL ENGINEERING JOURNAL, 433 (133645). [PMID:] |
25. Qianyu Li, Guoliang Li, Lihua Fan, Yanxin Yu, Jin Liu. (2022) Click reaction triggered turn-on fluorescence strategy for highly sensitive and selective determination of steroid hormones in food samples. FOOD CHEMISTRY, 374 (131565). [PMID:34875430] |
26. Dan Ouyang,Kailong Luo,Wende Ma,Jie Wu,Jing Li,Yanting He,Zongwei Cai,Zian Lin. (2020-03-13) A spherical covalent-organic framework for enhancing laser desorption/ionization mass spectrometry for small molecule detection.. The Analyst, 145 ((8)): (3125-3130). [PMID:32163066] |
1. Lianxu Wang, Zhen Lei, Sining Yun, Xiaohuan Yang, Rong Chen. (2024) Quantitative structure-biotransformation relationships of organic micropollutants in aerobic and anaerobic wastewater treatments. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (169170). [PMID:38072270] |
2. Yanting Li, Shu Zhu, Hua Zhao, Yan Xiong, Tao Gong, Yanru Tao, Jin Li, Jiangling Hu, Hongmei Wang, Xinhui Jiang. (2024) Cubic cobalt ferrite anchored on graphene sheets for non-enzymatic electrochemical detection of 17α-ethinyl estradiol in environmental and biological samples. Journal of Environmental Chemical Engineering, 12 (111612). [PMID:] |
3. Yue Bao, Yixin Zhai, Siyuan Di, Hailan Qin, Shukui Zhu. (2023) Room-temperature synthesis of magnetic thiophene-based covalent organic frameworks for derivatization-assisted GC–MS analysis of estrogens in environmental water. MICROCHEMICAL JOURNAL, 195 (7): (109524). [PMID:16281057] |
4. Yachao Hao, Wei Zhou, Xin Wang, Youping Liu, Xin Di. (2023) Carboxyl-based deep eutectic solvent modified magnetic graphene oxide as a novel adsorbent for fast enrichment and extraction of estrogens in milk prior to HPLC-UV analysis. MICROCHEMICAL JOURNAL, 193 (109050). [PMID:] |
5. Si-xuan Zhou, Xiao-tong Lin, Jie Wang, Hai-xiang Wang, Gui-tang Chen. (2023) Novel hydrocortisone magnetic molecularly imprinted polymers: Preparation, characterization, and application. FOOD CHEMISTRY, 421 (136196). [PMID:37116443] |
6. Qing Liu, Chao Yan, Yan Wang. (2023) Submicron Nonporous Silica Particles for Enhanced Separation Performance in pCEC. MOLECULES, 28 (8): (3542). [PMID:37110774] |
7. Haojie Zeng, Feiyun Sun, Jianjun Zhang, Ying Wang, Songwen Yang, Dingyu Xing. (2023) Gradient crosslinking optimization for the selective layer to prepare polyvinyl alcohol (PVA) nanofiltration (NF) membrane: The enhanced filtration performance and potential rejection for EDCs. JOURNAL OF MEMBRANE SCIENCE, 675 (121548). [PMID:] |
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