Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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E129595-1g | 1g | In stock | $58.90 | |
E129595-5g | 5g | In stock | $176.90 | |
E129595-25g | 25g | In stock | $795.90 |
Potent estrogen receptor agonist
Synonyms | Ethinylestradiol (Standard) | Ethynyloestradiol | Estigyn | 17-Ethinylestradiol | CHEBI:4903 | Ethinyl Estradiol [USP] | Ethynyl estradiol | Lynoral | Primogyn | 17a-Ethinylestradiol | 17a-Ethynylestradiol | 17-Ethynylestradiol | 423D2T571U | Ethinylestra |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Ethynyl Estradiol is a synthetic analog of estradiol, often used in combination with a progestin. Efficacy of administration is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Rapidly absorbed fr |
Storage Temp | Protected from light,Argon charged |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST, INHIBITOR |
Mechanism of action | Estrogen receptor alpha agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A synthetic estradiol analog. |
ALogP | 3.7 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179981 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179981 |
IUPAC Name | (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol |
INCHI | InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1 |
InChi Key | BFPYWIDHMRZLRN-SLHNCBLASA-N |
Canonical SMILES | CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O |
Isomeric SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O |
WGK Germany | 3 |
RTECS | RC8925000 |
PubChem CID | 5991 |
Molecular Weight | 296.4 |
Beilstein | 2419975 |
Reaxy-Rn | 7177007 |
DrugBank Ligand | DB00977 |
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PubChem CID | 5991 |
CAS Registry No. | 57-63-6 |
ChEMBL Ligand | CHEMBL691 |
Wikipedia | Ethinyl estradiol |
ChEBI | CHEBI:4903 |
NURSA Ligand | 10.1621/XLZYGNE63I |
RCSB PDB Ligand | 3WF |
PEP | ethinylestradiol |
DrugCentral Ligand | 1082 |
PubChem SID | 488179981 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
I2202433 | Certificate of Analysis | Jun 15, 2024 | E129595 |
E2112314 | Certificate of Analysis | Feb 13, 2023 | E129595 |
E2112311 | Certificate of Analysis | Feb 13, 2023 | E129595 |
E2112312 | Certificate of Analysis | Feb 13, 2023 | E129595 |
D23141567 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142118 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142185 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142186 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142221 | Certificate of Analysis | Jan 09, 2023 | E129595 |
D23142227 | Certificate of Analysis | Jan 09, 2023 | E129595 |
A2418083 | Certificate of Analysis | Jul 23, 2022 | E129595 |
I2202365 | Certificate of Analysis | Jul 23, 2022 | E129595 |
I2202432 | Certificate of Analysis | Jul 23, 2022 | E129595 |
Solubility | Soluble in ethanol (59 mg/ml at 25 °C), DMF (~20 mg/ml), DMSO (59 mg/ml at 25 °C), water (0.01 mg/ml at 27 °C), and methanol. |
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Sensitivity | light sensitive;Air sensitive |
Specific Rotation[α] | -30° (C=0.4,Pyridine) |
Melt Point(°C) | 181.0 - 185.0°C |
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H350:May cause cancer H362:May cause harm to breast-fed children |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | RC8925000 |
Reaxy-Rn | 7177007 |
Merck Index | 3734 |
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2. Yanting Li, Shu Zhu, Hua Zhao, Yan Xiong, Tao Gong, Yanru Tao, Jin Li, Jiangling Hu, Hongmei Wang, Xinhui Jiang. (2024) Cubic cobalt ferrite anchored on graphene sheets for non-enzymatic electrochemical detection of 17α-ethinyl estradiol in environmental and biological samples. Journal of Environmental Chemical Engineering, 12 (111612). [PMID:] [10.1016/j.jece.2023.111612] |
3. Yue Bao, Yixin Zhai, Siyuan Di, Hailan Qin, Shukui Zhu. (2023) Room-temperature synthesis of magnetic thiophene-based covalent organic frameworks for derivatization-assisted GC–MS analysis of estrogens in environmental water. MICROCHEMICAL JOURNAL, 195 (7): (109524). [PMID:16281057] [10.1016/j.microc.2023.109524] |
4. Yachao Hao, Wei Zhou, Xin Wang, Youping Liu, Xin Di. (2023) Carboxyl-based deep eutectic solvent modified magnetic graphene oxide as a novel adsorbent for fast enrichment and extraction of estrogens in milk prior to HPLC-UV analysis. MICROCHEMICAL JOURNAL, 193 (109050). [PMID:] [10.1016/j.microc.2023.109050] |
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9. Yunning Chen, Renquan Guan, Xueying Cheng, Jie Zhao, Zhengkai Wu, Yan Wang, Qingkun Shang, Yingnan Sun. (2023) Construction of surface oxygen vacancies by bimetallic doping combined with ellagic acid modification to enhance the photocatalytic degradation of ethinyl estradiol by TiO2. CHEMICAL ENGINEERING JOURNAL, 455 (140929). [PMID:] [10.1016/j.cej.2022.140929] |
10. Sun Min, Wang Xiuqin, Ding Yali, Feng Juanjuan. (2022) Titania hybridized melamine–formaldehyde aerogel for online in-tube solid-phase microextraction of polycyclic aromatic hydrocarbons prior to HPLC–DAD. MICROCHIMICA ACTA, 189 (12): (1-10). [PMID:36416994] [10.1007/s00604-022-05572-3] |
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14. Yanqun Yang, Yipeng Huang, Zhuqiang Wu, Rui Shi, Zhengyi Chen, Guihua Ruan. (2022) Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens. ANALYTICA CHIMICA ACTA, 1227 (340270). [PMID:36089309] [10.1016/j.aca.2022.340270] |
15. Yong Zhang, Kaifang Wei, Litao Wang, Guihua Gao. (2022) A membrane solid-phase extraction method based on MIL-53-mixed-matrix membrane for the determination of estrogens and parabens: Polyvinylidene difluoride membrane versus polystyrene-block-polybutadiene membrane. BIOMEDICAL CHROMATOGRAPHY, 36 (11): (e5454). [PMID:35853840] [10.1002/bmc.5454] |
16. Shuo Qi, Xiaoze Dong, Yuhan Sun, Yin Zhang, Nuo Duan, Zhouping Wang. (2022) Split aptamer remodeling-initiated target-self-service 3D-DNA walker for ultrasensitive detection of 17β-estradiol. JOURNAL OF HAZARDOUS MATERIALS, 439 (129590). [PMID:35872451] [10.1016/j.jhazmat.2022.129590] |
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19. Yuping Zhang, Ning Wang, Zhenyu Lu, Na Chen, Chengxing Cui, Xinxin Chen. (2022) Smart Titanium Wire Used for the Evaluation of Hydrophobic/Hydrophilic Interaction by In-Tube Solid Phase Microextraction. MOLECULES, 27 (7): (2353). [PMID:35408750] [10.3390/molecules27072353] |
20. Long Zhu, Mingrong Wang, Shuo Fu, Kaiqi Li, Jialin Liu, Zaizhao Wang. (2022) BPA disrupted the testis testosterone levels by interfering ER enrichments within StAR 5′ flanking region in rare minnow Gobiocypris rarus. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 257 (109338). [PMID:35381366] [10.1016/j.cbpc.2022.109338] |
21. Lingli Zhang, Han Tao, Chun Ji, Qiaoling Wu, Xiao Wang, Yuangeng Wu. (2022) Sensitive and direct electrochemical detection of bisphenol S based on 1T&2H-MoS2/CNTs-NH2 nanocomposites. NEW JOURNAL OF CHEMISTRY, 46 (17): (8203-8214). [PMID:] [10.1039/D2NJ00866A] |
22. Cai Xiunan, Tian Ling, Chen Meifei, Liu Yijun, Wang Wei, Long Junhao, Zhang Yanjuan, Tao Gan, Hu Huayu, Huang Zuqiang. (2022) Construction of a C-decorated and Cu-doped (Fe,Cu)S/CuFe2O4 solid solution for photo-Fenton degradation of hydrophobic organic contaminant: Enhanced electron transfer and adsorption capacity. CHEMOSPHERE, 296 (134005). [PMID:35181432] [10.1016/j.chemosphere.2022.134005] |
23. Huizhong Si, Pingping He, Xuemei Wang, Lin Li, Xiaohong Hou. (2022) Metal organic framework/chitosan/polyethylene oxide composite columnar foam as a sorbent for the enrichment and determination of estrogens in environmental aqueous solutions. NEW JOURNAL OF CHEMISTRY, 46 (2): (808-819). [PMID:] [10.1039/D1NJ02426D] |
24. Mingxia Sun, Juanjuan Feng, Jiaqing Feng, Haili Sun, Yang Feng, Xiangping Ji, Chunying Li, Sen Han, Min Sun. (2022) Biochar nanosphere- and covalent organic framework nanosphere-functionalized titanium dioxide nanorod arrays on carbon fibers for solid-phase microextraction of organic pollutants. CHEMICAL ENGINEERING JOURNAL, 433 (133645). [PMID:] [10.1016/j.cej.2021.133645] |
25. Qianyu Li, Guoliang Li, Lihua Fan, Yanxin Yu, Jin Liu. (2022) Click reaction triggered turn-on fluorescence strategy for highly sensitive and selective determination of steroid hormones in food samples. FOOD CHEMISTRY, 374 (131565). [PMID:34875430] [10.1016/j.foodchem.2021.131565] |
26. Xiaoxiao Zhu, Yijun Zhang, Pengfei Liu, Xiuzhi Bai, Na Chen, Yuping Zhang. (2021) Carbonized Aramid Fiber as the Adsorbent for In-Tube Solid-Phase Microextraction to Detect Estrogens in Water Samples. Journal of Chemistry, 2021 (9970518). [PMID:] [10.1155/2021/9970518] |
27. Peiqi Luo, Liping Wang, Lixia Jiang, Jie Sun, Yafeng Li, Huihui Liu, Caiqiao Xiong, Zongxiu Nie. (2021) Application of Graphdiyne in Surface-Assisted Laser Desorption Ionization Mass Spectrometry. ACS Applied Materials & Interfaces, 13 (1): (1914–1920). [PMID:33378159] [10.1021/acsami.0c18280] |
28. Kejian Tian, Fanxing Meng, Qi Meng, Yan Gao, Lili Zhang, Le Wang, Yuqing Wang, Xue Li, Hongliang Huo. (2020) The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001. International Journal of Genomics, 2020 (9369182). [PMID:32908857] [10.1155/2020/9369182] |
29. Xing Tian, Huijia Song, Yue Wang, Xuemeng Tian, Yuhai Tang, Ruixia Gao, Chengxiao Zhang. (2020) Hydrophilic magnetic molecularly imprinted nanobeads for efficient enrichment and high performance liquid chromatographic detection of 17beta-estradiol in environmental water samples. TALANTA, 220 (121367). [PMID:32928396] [10.1016/j.talanta.2020.121367] |
30. Shenling Wang, Yanling Geng, Xiaowei Sun, Rongyu Wang, Zhenjia Zheng, Shenghuai Hou, Xiao Wang, Wenhua Ji. (2020) Molecularly imprinted polymers prepared from a single cross-linking functional monomer for solid-phase microextraction of estrogens from milk. JOURNAL OF CHROMATOGRAPHY A, 1627 (461400). [PMID:32823105] [10.1016/j.chroma.2020.461400] |
31. Yuhan Zhu, Zuwei Xu, Jie Gao, Weihao Ji, Jingdong Zhang. (2020) An antibody-aptamer sandwich cathodic photoelectrochemical biosensor for the detection of progesterone. BIOSENSORS & BIOELECTRONICS, 160 (112210). [PMID:32339148] [10.1016/j.bios.2020.112210] |
32. Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yilin Li, Hao Lin, Ying Peng, Jiang Zheng. (2019) Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism. DRUG METABOLISM AND DISPOSITION, 47 (8): (919-927). [PMID:31147316] [10.1124/dmd.119.086892] |
33. Jian Wang, Xian Zhou, Michael Gatheru Waigi, Fredrick Owino Gudda, Pengfei Cheng, Wanting Ling. (2019) Simultaneous Removal of Estrogens and Antibiotics from Livestock Manure Using Fenton Oxidation Technique. Catalysts, 9 (8): (644). [PMID:] [10.3390/catal9080644] |
34. Siyao Liu, Yuqing Chen, Ying Wang, Guohua Zhao. (2019) Group-Targeting Detection of Total Steroid Estrogen Using Surface-Enhanced Raman Spectroscopy. ANALYTICAL CHEMISTRY, 91 (12): (7639–7647). [PMID:31144808] [10.1021/acs.analchem.9b00534] |
35. Yan Xing, Jing Cheng, Mengfei Zhang, Meng Zhao, Liyan Ye, Wei Pan. (2018) A Novel Inorganic Ni–La2O3 Composite with Superfast and Versatile Water Purification Behavior. ACS Applied Materials & Interfaces, 10 (50): (43723–43729). [PMID:30475586] [10.1021/acsami.8b17114] |
36. Yu Zong, Jia Chen, Jinxuan Hou, Wenwen Deng, Xiaoyan Liao, Yuxiu Xiao. (2018) Hexafluoroisopropanol-alkyl carboxylic acid high-density supramolecular solvent based dispersive liquid-liquid microextraction of steroid sex hormones in human urine. JOURNAL OF CHROMATOGRAPHY A, 1580 (12). [PMID:30391035] [10.1016/j.chroma.2018.10.041] |
37. Xiaoli Qi, Hui Hu, Yuesuo Yang, Yunxian Piao. (2018) Graphite nanoparticle as nanoquencher for 17β-estradiol detection using shortened aptamer sequence. ANALYST, 143 (17): (4163-4170). [PMID:30069557] [10.1039/C8AN00591E] |
38. Xianze Wang, Zhongmou Liu, Zhian Ying, Mingxin Huo, Wu Yang. (2018) Adsorption of Trace Estrogens in Ultrapure and Wastewater Treatment Plant Effluent by Magnetic Graphene Oxide. International Journal of Environmental Research and Public Health, 15 (7): (1454). [PMID:29996530] [10.3390/ijerph15071454] |
39. Lei Chen, Mingyue Zhang, Fengfu Fu, Jingguang Li, Zian Lin. (2018) Facile synthesis of magnetic covalent organic framework nanobeads and application to magnetic solid-phase extraction of trace estrogens from human urine. JOURNAL OF CHROMATOGRAPHY A, 1567 (136). [PMID:30100013] [10.1016/j.chroma.2018.06.066] |
40. Lingshuai Kong, Guodong Fang, Ya Kong, Meng Xie, Vinothkumar Natarajan, Dongmei Zhou, Jinhua Zhan. (2018) Cu2O@β-cyclodextrin as a synergistic catalyst for hydroxyl radical generation and molecular recognitive destruction of aromatic pollutants at neutral pH. JOURNAL OF HAZARDOUS MATERIALS, 357 (109). [PMID:29870895] [10.1016/j.jhazmat.2018.05.065] |
41. Xiaojiao Du, Ding Jiang, Liming Dai, Weiran Zhu, Xiaodi Yang, Nan Hao, Kun Wang. (2018) Oxygen Vacancy Engineering in Europia Clusters/Graphite-Like Carbon Nitride Nanostructures Induced Signal Amplification for Highly Efficient Electrochemiluminesce Aptasensing. ANALYTICAL CHEMISTRY, 90 (5): (3615–3620). [PMID:29397697] [10.1021/acs.analchem.8b00162] |
42. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou. (2018) A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS. TALANTA, 180 (358). [PMID:29332823] [10.1016/j.talanta.2017.12.071] |
43. Jun Ding, Qiang Gao, Xiao-Shui Li, Wei Huang, Zhi-Guo Shi, Yu-Qi Feng. (2011) Magnetic solid-phase extraction based on magnetic carbon nanotube for the determination of estrogens in milk. JOURNAL OF SEPARATION SCIENCE, 34 (18): (2498-2504). [PMID:21780288] [10.1002/jssc.201100323] |
44. Dan Ouyang,Kailong Luo,Wende Ma,Jie Wu,Jing Li,Yanting He,Zongwei Cai,Zian Lin. (2020-03-13) A spherical covalent-organic framework for enhancing laser desorption/ionization mass spectrometry for small molecule detection.. The Analyst, 145 ((8)): (3125-3130). [PMID:32163066] |
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33. Jian Wang, Xian Zhou, Michael Gatheru Waigi, Fredrick Owino Gudda, Pengfei Cheng, Wanting Ling. (2019) Simultaneous Removal of Estrogens and Antibiotics from Livestock Manure Using Fenton Oxidation Technique. Catalysts, 9 (8): (644). [PMID:] [10.3390/catal9080644] |
34. Siyao Liu, Yuqing Chen, Ying Wang, Guohua Zhao. (2019) Group-Targeting Detection of Total Steroid Estrogen Using Surface-Enhanced Raman Spectroscopy. ANALYTICAL CHEMISTRY, 91 (12): (7639–7647). [PMID:31144808] [10.1021/acs.analchem.9b00534] |
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38. Xianze Wang, Zhongmou Liu, Zhian Ying, Mingxin Huo, Wu Yang. (2018) Adsorption of Trace Estrogens in Ultrapure and Wastewater Treatment Plant Effluent by Magnetic Graphene Oxide. International Journal of Environmental Research and Public Health, 15 (7): (1454). [PMID:29996530] [10.3390/ijerph15071454] |
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42. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou. (2018) A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS. TALANTA, 180 (358). [PMID:29332823] [10.1016/j.talanta.2017.12.071] |
43. Jun Ding, Qiang Gao, Xiao-Shui Li, Wei Huang, Zhi-Guo Shi, Yu-Qi Feng. (2011) Magnetic solid-phase extraction based on magnetic carbon nanotube for the determination of estrogens in milk. JOURNAL OF SEPARATION SCIENCE, 34 (18): (2498-2504). [PMID:21780288] [10.1002/jssc.201100323] |
44. Dan Ouyang,Kailong Luo,Wende Ma,Jie Wu,Jing Li,Yanting He,Zongwei Cai,Zian Lin. (2020-03-13) A spherical covalent-organic framework for enhancing laser desorption/ionization mass spectrometry for small molecule detection.. The Analyst, 145 ((8)): (3125-3130). [PMID:32163066] |