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Ethinyl Estradiol - ≥98%, high purity , Estrogen receptor alpha agonist, CAS No.57-63-6, Estrogen receptor alpha agonist
Potent estrogen receptor agonist
Basic Description Synonyms ethinyl estradiol|Ethynylestradiol|57-63-6|Ethynyl estradiol|ETHINYLESTRADIOL|Ethinyloestradiol|17-Ethinylestradiol|Estinyl|Ginestrene|17alpha-Ethynylestradiol|Amenoron|Dyloform|Estorals|Ethinoral|Eticyclin|Eticyclol|Etinestrol|Etinestryl|Etinoestryl|Etis Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Ethynyl Estradiol is a synthetic analog of estradiol, often used in combination with a progestin. Efficacy of administration is facilitated by the ethynyl substitution at the C-17 position, which inhibits first pass hepatic metabolism. Rapidly absorbed fr Storage Temp Protected from light,Argon charged Shipped In Normal Grade Moligand™ Action Type AGONIST, INHIBITOR Mechanism of action Estrogen receptor alpha agonist Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description A synthetic estradiol analog.
Names and Identifiers Pubchem Sid 488179981 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488179981 IUPAC Name (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol INCHI InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1 InChi Key BFPYWIDHMRZLRN-SLHNCBLASA-N Canonical SMILES CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O Isomeric SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O WGK Germany 3 RTECS RC8925000 PubChem CID 5991 Molecular Weight 296.4 Beilstein 2419975 Reaxy-Rn 7177007
Chemical and Physical Properties Solubility Soluble in ethanol (59 mg/ml at 25 °C), DMF (~20 mg/ml), DMSO (59 mg/ml at 25 °C), water (0.01 mg/ml at 27 °C), and methanol. Sensitivity light sensitive;Air sensitive Specific Rotation[α] -30° (C=0.4,Pyridine) Melt Point(°C) 181.0 - 185.0°C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 , GHS07 Signal Danger Hazard Statements H351: Suspected of causing cancer
H302: Harmful if swallowed
H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
H372: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
H350: May cause cancer
H362: May cause harm to breast-fed children
Precautionary Statements P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P330: Rinse mouth.
P263: Avoid contact during pregnancy/while nursing.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
WGK Germany 3 RTECS RC8925000 Reaxy-Rn 7177007 Merck Index 3734
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