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Ethyl 3,4-dihydroxybenzylidenecyanoacetate - ≥96%, high purity , CAS No.132464-92-7

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Ethyl 3,4-dihydroxybenzylidenecyanoacetate - ≥96%, high purity , CAS No.132464-92-7

≥96%

CAS#: 132464-92-7
Formula: C₁₂H₁₁NO₄
Molecular Weight: 233.2
PubChem CID: 14840960

Item Number

E334439

Grouped product items
SKU	Size	Availability	Price	Qty
E334439-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$40.90

a 12-LO and 15-LO inhibitor

Basic Description

Synonyms	132464-92-7 \| 2-(1-THIENYL)ETHYL 3,4-DIHYDROXYBENZYLIDENECYANOACETATE \| CHEMBL38168 \| Ethyl 3,4-dihydroxy-benzylidenecyanoacetate \| ethyl (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoate \| Ethyl 2-cyano-3-(3,4-dihydroxyphenyl)acrylate \| 126716-40-3 \| SCHEMBL9218611 \| DTX
Specifications & Purity	≥96%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	Ethyl 3,4-dihydroxybenzylidenecyanoacetate is an inhibitor of 12-LO (12-lipoxygenase) and 15-LO (15-lipoxygenase). 12-LO is an enzyme involved in the lipoxygenase pathway and plays a major role in promoting prostate cancer progression and metastasis. 15-LO enzyme has been associated with antherosclerosis and cancer.

Product Properties

pKa	pKₐ: 8.79 (Predicted)

Associated Targets(Human)

ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)

Discover Target: ALOX5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX12 Tchem Arachidonate 12-lipoxygenase (3262 Activities)

Discover Target: ALOX12

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver (3974 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNK2 Potassium channel subfamily K member 2 (9 Activities)

Discover Target: KCNK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	ethyl (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoate
INCHI	InChI=1S/C12H11NO4/c1-2-17-12(16)9(7-13)5-8-3-4-10(14)11(15)6-8/h3-6,14-15H,2H2,1H3/b9-5+
InChi Key	RAHIHNWEZPLHGV-WEVVVXLNSA-N
Canonical SMILES	CCOC(=O)C(=CC1=CC(=C(C=C1)O)O)C#N
Isomeric SMILES	CCOC(=O)/C(=C/C1=CC(=C(C=C1)O)O)/C#N
PubChem CID	14840960
Molecular Weight	233.2

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Soluble in DMSO, and methanol.
Refractive Index	n20D1.63 (Predicted)
Boil Point(°C)	437.92° C at 760 mmHg (Predicted)

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